CARDIOMETABOLIC DISORDERS AND ENDOTOXEMIA IN THE CONTEXT OF PERIODONTITIS – THE IMPORTANCE OF METABOLOMICS. A NARRATIVE REVIEW
Periodontitis patients are known to have increased circulating lipopolysaccharide activity and metabolic disturbances, which may be either the cause or effect of endotoxemia. This review approaches endotoxemia as a possible molecular mediator between periodontitis and increased risk of cardiometa...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Romanian Dental Association for Education
2022-12-01
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| Series: | Romanian Journal of Medical and Dental Education |
| Subjects: | |
| Online Access: | https://journal.adre.ro/cardiometabolic-disorders-and-endotoxemia-in-the-context-of-periodontitis-the-importance-of-metabolomics-a-narrative-review/ |
| _version_ | 1827962995624378368 |
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| author | Maria–Alexandra Martu Liliana Pasarin Ana-Maria Sciuca Cristina Popa George-Alexandru Maftei Ovidiu Nicolaiciuc Oana Butnaru Ruxandra Stan Silvia Martu Ionut Luchian |
| author_facet | Maria–Alexandra Martu Liliana Pasarin Ana-Maria Sciuca Cristina Popa George-Alexandru Maftei Ovidiu Nicolaiciuc Oana Butnaru Ruxandra Stan Silvia Martu Ionut Luchian |
| author_sort | Maria–Alexandra Martu |
| collection | DOAJ |
| description | Periodontitis patients are known to have increased circulating lipopolysaccharide activity and metabolic disturbances, which may be either the cause or effect of endotoxemia.
This review approaches endotoxemia as a possible molecular mediator between periodontitis and increased risk of cardiometabolic disorders. Observations that bacteria disseminate into circulation after toothbrushing and periodontal procedures and assumptions that endotoxin may disseminate through inflamed periodontium and bleeding gums support the idea of endotoxemia in periodontitis. However, the evidence that periodontitis-associated dysbiosis contributes to endotoxemia is not as strong as in the case of gut microbiome dysbiosis.
Although the causality is insufficiently demonstrated thus far, many studies have associated changes of the gut microbiome composition, function, and specific bacterial metabolites with cardiometabolic diseases, whereas research on the oral microbiome has severely fallen behind. |
| first_indexed | 2024-04-09T16:51:11Z |
| format | Article |
| id | doaj.art-5fdaa3799b414b72a465291e5cb4bb4f |
| institution | Directory Open Access Journal |
| issn | 2393-1108 2393-1531 |
| language | English |
| last_indexed | 2024-04-09T16:51:11Z |
| publishDate | 2022-12-01 |
| publisher | Romanian Dental Association for Education |
| record_format | Article |
| series | Romanian Journal of Medical and Dental Education |
| spelling | doaj.art-5fdaa3799b414b72a465291e5cb4bb4f2023-04-21T11:53:38ZengRomanian Dental Association for EducationRomanian Journal of Medical and Dental Education2393-11082393-15312022-12-01116617CARDIOMETABOLIC DISORDERS AND ENDOTOXEMIA IN THE CONTEXT OF PERIODONTITIS – THE IMPORTANCE OF METABOLOMICS. A NARRATIVE REVIEWMaria–Alexandra Martu0Liliana Pasarin1Ana-Maria Sciuca2Cristina Popa3George-Alexandru Maftei4Ovidiu Nicolaiciuc5Oana Butnaru6Ruxandra Stan7Silvia Martu8Ionut Luchian9“Gr.T.Popa" U.M.Ph. -Iași, Romania, Faculty of Dentistry, Department of Periodontology“Gr.T.Popa" U.M.Ph. -Iași, Romania, Faculty of Dentistry, Department of Periodontology “Gr.T.Popa" U.M.Ph., Iași, Romania, Faculty of Dentistry, Department of Oral Medicine “Gr.T.Popa" U.M.Ph., Iași, Romania, Faculty of Dentistry, Department of Oral Medicine “Gr.T.Popa" U.M.Ph., Iași, Romania, Faculty of Dentistry, Department of Oral Medicine“Gr.T.Popa" U.M.Ph. -Iași, Romania, Faculty of Dentistry, Department of Implantology, Removable Dentures, Dental Technology”Grigore T. Popa” U.M.Ph, Iasi Romania, Faculty of Dental Medicine, Department of Biophysics“Gr.T.Popa" U.M.Ph. -Iași, Romania, Faculty of Dentistry“Gr.T.Popa" U.M.Ph. -Iași, Romania, Faculty of Dentistry, Department of Periodontology“Gr.T.Popa" U.M.Ph. -Iași, Romania, Faculty of Dentistry, Department of PeriodontologyPeriodontitis patients are known to have increased circulating lipopolysaccharide activity and metabolic disturbances, which may be either the cause or effect of endotoxemia. This review approaches endotoxemia as a possible molecular mediator between periodontitis and increased risk of cardiometabolic disorders. Observations that bacteria disseminate into circulation after toothbrushing and periodontal procedures and assumptions that endotoxin may disseminate through inflamed periodontium and bleeding gums support the idea of endotoxemia in periodontitis. However, the evidence that periodontitis-associated dysbiosis contributes to endotoxemia is not as strong as in the case of gut microbiome dysbiosis. Although the causality is insufficiently demonstrated thus far, many studies have associated changes of the gut microbiome composition, function, and specific bacterial metabolites with cardiometabolic diseases, whereas research on the oral microbiome has severely fallen behind.https://journal.adre.ro/cardiometabolic-disorders-and-endotoxemia-in-the-context-of-periodontitis-the-importance-of-metabolomics-a-narrative-review/periodontitiscardiometabolic disordersendotoxemiametabolomics |
| spellingShingle | Maria–Alexandra Martu Liliana Pasarin Ana-Maria Sciuca Cristina Popa George-Alexandru Maftei Ovidiu Nicolaiciuc Oana Butnaru Ruxandra Stan Silvia Martu Ionut Luchian CARDIOMETABOLIC DISORDERS AND ENDOTOXEMIA IN THE CONTEXT OF PERIODONTITIS – THE IMPORTANCE OF METABOLOMICS. A NARRATIVE REVIEW Romanian Journal of Medical and Dental Education periodontitis cardiometabolic disorders endotoxemia metabolomics |
| title | CARDIOMETABOLIC DISORDERS AND ENDOTOXEMIA IN THE CONTEXT OF PERIODONTITIS – THE IMPORTANCE OF METABOLOMICS. A NARRATIVE REVIEW |
| title_full | CARDIOMETABOLIC DISORDERS AND ENDOTOXEMIA IN THE CONTEXT OF PERIODONTITIS – THE IMPORTANCE OF METABOLOMICS. A NARRATIVE REVIEW |
| title_fullStr | CARDIOMETABOLIC DISORDERS AND ENDOTOXEMIA IN THE CONTEXT OF PERIODONTITIS – THE IMPORTANCE OF METABOLOMICS. A NARRATIVE REVIEW |
| title_full_unstemmed | CARDIOMETABOLIC DISORDERS AND ENDOTOXEMIA IN THE CONTEXT OF PERIODONTITIS – THE IMPORTANCE OF METABOLOMICS. A NARRATIVE REVIEW |
| title_short | CARDIOMETABOLIC DISORDERS AND ENDOTOXEMIA IN THE CONTEXT OF PERIODONTITIS – THE IMPORTANCE OF METABOLOMICS. A NARRATIVE REVIEW |
| title_sort | cardiometabolic disorders and endotoxemia in the context of periodontitis the importance of metabolomics a narrative review |
| topic | periodontitis cardiometabolic disorders endotoxemia metabolomics |
| url | https://journal.adre.ro/cardiometabolic-disorders-and-endotoxemia-in-the-context-of-periodontitis-the-importance-of-metabolomics-a-narrative-review/ |
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