Clinical value of serum homocysteine, folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion
Background: To investigate the clinical value of serum homocysteine (Hcy), folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion.Methods: Ninety-eight pregnant women within 12 weeks of gestation were included in the study. Of these subjects, 29 presented...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2019-03-01
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| Series: | Pteridines |
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| Online Access: | https://doi.org/10.1515/pteridines-2019-0002 |
| _version_ | 1818580746820911104 |
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| author | Wu Wenhai Ji Qinglin Guo Baoli Yu Jinfen Wang Jiewei Wang Yezhu Xu Juan |
| author_facet | Wu Wenhai Ji Qinglin Guo Baoli Yu Jinfen Wang Jiewei Wang Yezhu Xu Juan |
| author_sort | Wu Wenhai |
| collection | DOAJ |
| description | Background: To investigate the clinical value of serum homocysteine (Hcy), folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion.Methods: Ninety-eight pregnant women within 12 weeks of gestation were included in the study. Of these subjects, 29 presented with threatened abortion and were considered the case group (n=29). The other 69 subjects showed as a normal pregnancy were the control group (n=69). The case group was followed up with at 28 weeks of gestation, and further divided into inevitable abortion group (IA, n=9) and successful fetus protection group (SFP, n=20). The yolk sacs of the included cases were measured by ultrasonography. The serum Hcy and folate levels of the included cases were measured by an enzyme cycling assay and chemiluminescent immunoassay, respectively. The yolk sac visualization rate and serum Hcy and folate levels were compared between the two case groups and used as a predicting reference for the outcome of threatened abortion. Results: The yolk sac visualization rates detected by ultrasonography were 97.1% (67/69) for the control group and 69.0% (20/29) for the threatened abortion group, with a statistical difference (p<0.05). For the IA and SFP groups, the visualization rates were 22.2% (2/9) and 90.0% (18/20) respectively, with a statistical difference (p<0.05). The serum Hcy levels in the threatened abortion group were significant elevated compared with control group (6.1±2.0 μmol/L vs 4.5±1.3 μmol/L), with a statistical difference (p<0.05). However, the serum levels of folat in the threatened abortion group were significantly decreased compared with the control group (15.5±4.2 nmol/L vs 19.1±4.7 nmol/L), with a statistical difference (p<0.05). The serum levels of Hcy and folate were 7.5±1.7 μmol/L and 12.7±4.2 nmol/L for the IA group, which were statistically different compared to the SFP group (p<0.05). The predictive sensitivity for the outcome of threatened abortion based on serum Hcy and folate levels were 85.0% and 75.0%, with a predictive specificity of 66.7% and 88.9% respectively. Conclusion: Serum Hcy and folate levels were quite different in threatened abortion pregnant woman compared to the control group. Serum Hcy and folate level detection combined with ultrasonography detection of yolk sac can provide useful information for threatened abortions |
| first_indexed | 2024-12-16T07:22:30Z |
| format | Article |
| id | doaj.art-5fdaafa5eaf24b99a98a37ab6eb873fd |
| institution | Directory Open Access Journal |
| issn | 0933-4807 2195-4720 |
| language | English |
| last_indexed | 2024-12-16T07:22:30Z |
| publishDate | 2019-03-01 |
| publisher | De Gruyter |
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| series | Pteridines |
| spelling | doaj.art-5fdaafa5eaf24b99a98a37ab6eb873fd2022-12-21T22:39:36ZengDe GruyterPteridines0933-48072195-47202019-03-01301101510.1515/pteridines-2019-0002pteridines-2019-0002Clinical value of serum homocysteine, folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortionWu Wenhai0Ji Qinglin1Guo Baoli2Yu Jinfen3Wang Jiewei4Wang Yezhu5Xu Juan6Department of imaging, Zhangqiu Maternal and Child Health Care Hospital of Jinan City,ShandongProvince 250200 PR ChinaDepartment of imaging, Zhangqiu Maternal and Child Health Care Hospital of Jinan City,ShandongProvince 250200 PR ChinaDepartment of imaging, Zhangqiu Maternal and Child Health Care Hospital of Jinan City,ShandongProvince 250200 PR ChinaDepartment of imaging, Zhangqiu Maternal and Child Health Care Hospital of Jinan City,ShandongProvince 250200 PR ChinaDepartment of imaging, Zhangqiu Maternal and Child Health Care Hospital of Jinan City,ShandongProvince 250200 PR ChinaDepartment of imaging, Zhangqiu Maternal and Child Health Care Hospital of Jinan City,ShandongProvince 250200 PR ChinaDepartment of imaging, Zhangqiu Maternal and Child Health Care Hospital of Jinan City,ShandongProvince 250200 PR ChinaBackground: To investigate the clinical value of serum homocysteine (Hcy), folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion.Methods: Ninety-eight pregnant women within 12 weeks of gestation were included in the study. Of these subjects, 29 presented with threatened abortion and were considered the case group (n=29). The other 69 subjects showed as a normal pregnancy were the control group (n=69). The case group was followed up with at 28 weeks of gestation, and further divided into inevitable abortion group (IA, n=9) and successful fetus protection group (SFP, n=20). The yolk sacs of the included cases were measured by ultrasonography. The serum Hcy and folate levels of the included cases were measured by an enzyme cycling assay and chemiluminescent immunoassay, respectively. The yolk sac visualization rate and serum Hcy and folate levels were compared between the two case groups and used as a predicting reference for the outcome of threatened abortion. Results: The yolk sac visualization rates detected by ultrasonography were 97.1% (67/69) for the control group and 69.0% (20/29) for the threatened abortion group, with a statistical difference (p<0.05). For the IA and SFP groups, the visualization rates were 22.2% (2/9) and 90.0% (18/20) respectively, with a statistical difference (p<0.05). The serum Hcy levels in the threatened abortion group were significant elevated compared with control group (6.1±2.0 μmol/L vs 4.5±1.3 μmol/L), with a statistical difference (p<0.05). However, the serum levels of folat in the threatened abortion group were significantly decreased compared with the control group (15.5±4.2 nmol/L vs 19.1±4.7 nmol/L), with a statistical difference (p<0.05). The serum levels of Hcy and folate were 7.5±1.7 μmol/L and 12.7±4.2 nmol/L for the IA group, which were statistically different compared to the SFP group (p<0.05). The predictive sensitivity for the outcome of threatened abortion based on serum Hcy and folate levels were 85.0% and 75.0%, with a predictive specificity of 66.7% and 88.9% respectively. Conclusion: Serum Hcy and folate levels were quite different in threatened abortion pregnant woman compared to the control group. Serum Hcy and folate level detection combined with ultrasonography detection of yolk sac can provide useful information for threatened abortionshttps://doi.org/10.1515/pteridines-2019-0002homocysteinefolateultrasonographyyolk sacthreatened abortion |
| spellingShingle | Wu Wenhai Ji Qinglin Guo Baoli Yu Jinfen Wang Jiewei Wang Yezhu Xu Juan Clinical value of serum homocysteine, folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion Pteridines homocysteine folate ultrasonography yolk sac threatened abortion |
| title | Clinical value of serum homocysteine, folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion |
| title_full | Clinical value of serum homocysteine, folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion |
| title_fullStr | Clinical value of serum homocysteine, folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion |
| title_full_unstemmed | Clinical value of serum homocysteine, folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion |
| title_short | Clinical value of serum homocysteine, folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion |
| title_sort | clinical value of serum homocysteine folate and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion |
| topic | homocysteine folate ultrasonography yolk sac threatened abortion |
| url | https://doi.org/10.1515/pteridines-2019-0002 |
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