CRISPR-Cas– induced IRF3 and MAVS knockouts in a salmonid cell line disrupt PRR signaling and affect viral replication

CRISPR-Cas– induced IRF3 and MAVS knockouts in a salmonid cell line disrupt PRR signaling and affect viral replication

BackgroundInterferon (IFN) responses are critical in the resolution of viral infections and are actively targeted by many viruses. They also play a role in inducing protective responses after vaccination and have been successfully tested as vaccine adjuvants. IFN responses are well conserved and fun...

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Bibliographic Details
Main Authors: Yorick A. van der Wal, Henriette Nordli, Allan Akandwanaho, Linn Greiner-Tollersrud, Jaap Kool, Jorunn B. Jørgensen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
Salmon alphavirus
CHSE-214
CRISPR-Cas
IFN responses
PRR signaling
MAVS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1214912/full

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