Multiple knockout mouse models reveal lincRNAs are required for life and brain development
Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological conditions, we have developed a collection of 18 lncRN...
Main Authors: | Martin Sauvageau, Loyal A Goff, Simona Lodato, Boyan Bonev, Abigail F Groff, Chiara Gerhardinger, Diana B Sanchez-Gomez, Ezgi Hacisuleyman, Eric Li, Matthew Spence, Stephen C Liapis, William Mallard, Michael Morse, Mavis R Swerdel, Michael F D’Ecclessis, Jennifer C Moore, Venus Lai, Guochun Gong, George D Yancopoulos, David Frendewey, Manolis Kellis, Ronald P Hart, David M Valenzuela, Paola Arlotta, John L Rinn |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2013-12-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/01749 |
Similar Items
-
Multiple knockout mouse models reveal lincRNAs are required for life and brain development
by: Goff, Loyal, et al.
Published: (2014) -
Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain
by: Goff, Loyal A., et al.
Published: (2016) -
lincRNAs act in the circuitry controlling pluripotency and differentiation
by: Guttman, Mitchell, et al.
Published: (2012) -
lincRNAs: Genomics, Evolution, and Mechanisms
by: Ulitsky, Igor, et al.
Published: (2015) -
Long noncoding RNAs regulate adipogenesis
by: Sun, Lei, et al.
Published: (2013)