Computer-Aided Design of α-L-Rhamnosidase to Increase the Synthesis Efficiency of Icariside I
Icariside I, the glycosylation product of icaritin, is a novel effective anti-cancer agent with immunological anti-tumor activity. However, very limited natural icariside I content hinders its direct extraction from plants. Therefore, we employed a computer-aided protein design strategy to improve t...
Main Authors: | Jia-Jun Huang, Hao-Xuan Hu, Yu-Jing Lu, Ya-Dan Bao, Jin-Lin Zhou, Mingtao Huang |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-06-01
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Series: | Frontiers in Bioengineering and Biotechnology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.926829/full |
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