Glomerulonephritis Histopathological Pattern Change
Abstract Background Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic pro...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-020-01836-3 |
| _version_ | 1828394241511915520 |
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| author | Anas AlYousef Ali AlSahow Bassam AlHelal Ahmed Alqallaf Emad Abdallah Mohammed Abdellatif Hani Nawar Riham Elmahalawy |
| author_facet | Anas AlYousef Ali AlSahow Bassam AlHelal Ahmed Alqallaf Emad Abdallah Mohammed Abdellatif Hani Nawar Riham Elmahalawy |
| author_sort | Anas AlYousef |
| collection | DOAJ |
| description | Abstract Background Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic procedure of choice with variable indications from center to center. It helps in identifying the exact specific diagnosis, assessing the level of disease activity and severity, and hence aids in proper therapy and helps predicting prognosis. There is a global change of pattern of glomerular disease over the last five decades. Methods Retrospective analysis of all kidney biopsies (545 cases) that were done in patients over 12 year-old over last six years in four major hospitals in Kuwait. The indications for kidney biopsy were categorized into six clinical syndromes: nephrotic syndrome, sub-nephrotic proteinuria, nephrotic syndrome plus acute kidney injury (AKI), sub-nephrotic proteinuria plus AKI, isolated hematuria, and Unexplained renal impairment. We calculated the incidence of each type of kidney disease and indication of biopsy. Results most common indication of kidney biopsy was sub-nephrotic proteinuria associated with AKI in 179 cases (32.8%). Primary Glomerulonephritis was the main diagnosis that was reported in 356 cases (65.3%). Immunoglobulin A Nephropathy (IgAN) was the commonest lesion in primary glomerulonephritis in 85 (23.9%) cases. Secondary Glomerulonephritis was diagnosed in 134 cases (24.6%), 56 (41.8%) of them were reported as lupus nephritis cases. In young adults (below 18 years of age) there were 31 cases reviews, 35.5% were found to have minimal change disease (MCD). Conclusion IgAN is the commonest glomerulonephritis in primary nephrotic syndromes in Kuwait over the past six years. Lupus nephritis is the leading secondary glomerulonephritis diagnosis. |
| first_indexed | 2024-12-10T07:51:54Z |
| format | Article |
| id | doaj.art-5fdce90f1b854bb19b87b754a66c34e4 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-10T07:51:54Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-5fdce90f1b854bb19b87b754a66c34e42022-12-22T01:57:00ZengBMCBMC Nephrology1471-23692020-05-012111710.1186/s12882-020-01836-3Glomerulonephritis Histopathological Pattern ChangeAnas AlYousef0Ali AlSahow1Bassam AlHelal2Ahmed Alqallaf3Emad Abdallah4Mohammed Abdellatif5Hani Nawar6Riham Elmahalawy7Farwaniya Hospital, Department of Internal Medicine, Nephrology UnitAl Jahra Hospital, Department of Internal Medicine, Nephrology UnitAl Adan Hospital, Department of Internal Medicine, Nephrology UnitMubarak Al-Kabeer Hospital, Department of Internal Medicine, Nephrology UnitAl Adan Hospital, Department of Internal Medicine, Nephrology UnitFarwaniya Hospital, Department of Internal Medicine, Nephrology UnitAl Jahra Hospital, Department of Internal Medicine, Nephrology UnitMubarak Al-Kabeer Hospital, Department of Internal Medicine, Nephrology UnitAbstract Background Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic procedure of choice with variable indications from center to center. It helps in identifying the exact specific diagnosis, assessing the level of disease activity and severity, and hence aids in proper therapy and helps predicting prognosis. There is a global change of pattern of glomerular disease over the last five decades. Methods Retrospective analysis of all kidney biopsies (545 cases) that were done in patients over 12 year-old over last six years in four major hospitals in Kuwait. The indications for kidney biopsy were categorized into six clinical syndromes: nephrotic syndrome, sub-nephrotic proteinuria, nephrotic syndrome plus acute kidney injury (AKI), sub-nephrotic proteinuria plus AKI, isolated hematuria, and Unexplained renal impairment. We calculated the incidence of each type of kidney disease and indication of biopsy. Results most common indication of kidney biopsy was sub-nephrotic proteinuria associated with AKI in 179 cases (32.8%). Primary Glomerulonephritis was the main diagnosis that was reported in 356 cases (65.3%). Immunoglobulin A Nephropathy (IgAN) was the commonest lesion in primary glomerulonephritis in 85 (23.9%) cases. Secondary Glomerulonephritis was diagnosed in 134 cases (24.6%), 56 (41.8%) of them were reported as lupus nephritis cases. In young adults (below 18 years of age) there were 31 cases reviews, 35.5% were found to have minimal change disease (MCD). Conclusion IgAN is the commonest glomerulonephritis in primary nephrotic syndromes in Kuwait over the past six years. Lupus nephritis is the leading secondary glomerulonephritis diagnosis.http://link.springer.com/article/10.1186/s12882-020-01836-3Diabetic Kidney DiseaseGlomerulonephritisIgA NephropathyKidney Biopsy Nephrotic Syndrome |
| spellingShingle | Anas AlYousef Ali AlSahow Bassam AlHelal Ahmed Alqallaf Emad Abdallah Mohammed Abdellatif Hani Nawar Riham Elmahalawy Glomerulonephritis Histopathological Pattern Change BMC Nephrology Diabetic Kidney Disease Glomerulonephritis IgA Nephropathy Kidney Biopsy Nephrotic Syndrome |
| title | Glomerulonephritis Histopathological Pattern Change |
| title_full | Glomerulonephritis Histopathological Pattern Change |
| title_fullStr | Glomerulonephritis Histopathological Pattern Change |
| title_full_unstemmed | Glomerulonephritis Histopathological Pattern Change |
| title_short | Glomerulonephritis Histopathological Pattern Change |
| title_sort | glomerulonephritis histopathological pattern change |
| topic | Diabetic Kidney Disease Glomerulonephritis IgA Nephropathy Kidney Biopsy Nephrotic Syndrome |
| url | http://link.springer.com/article/10.1186/s12882-020-01836-3 |
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