Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis
Lipid metabolism alterations are an important component of the pathogenesis of atherosclerosis. However, it is now clear that the atherogenesis process involves more than one mechanism, and more than one condition can predispose this condition. Multiple risk factors contribute to the atherosclerosis...
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2639 |
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| author | Anastasia V. Poznyak Larisa Litvinova Paolo Poggio Alexander N. Orekhov Alexandra A. Melnichenko |
| author_facet | Anastasia V. Poznyak Larisa Litvinova Paolo Poggio Alexander N. Orekhov Alexandra A. Melnichenko |
| author_sort | Anastasia V. Poznyak |
| collection | DOAJ |
| description | Lipid metabolism alterations are an important component of the pathogenesis of atherosclerosis. However, it is now clear that the atherogenesis process involves more than one mechanism, and more than one condition can predispose this condition. Multiple risk factors contribute to the atherosclerosis initiation and define its course. Familial hypercholesterolaemia is a disorder of lipid metabolism that often leads to atherosclerosis development. As is clear from the disease name, the hallmark is the increased levels of low-density lipoprotein cholesterol (LDL-C) in blood. This creates favourable conditions for atherogenesis. In this review, we briefly described the familial hypercholesterolaemia and summarized data on the relationship between familial hypercholesterolaemia and atherosclerosis. |
| first_indexed | 2024-03-09T20:37:51Z |
| format | Article |
| id | doaj.art-5fddedd645fb4ea9aaf4ebef3c277bec |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:37:51Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5fddedd645fb4ea9aaf4ebef3c277bec2023-11-23T23:06:21ZengMDPI AGBiomedicines2227-90592022-10-011010263910.3390/biomedicines10102639Familial Hypercholesterolaemia as a Predisposing Factor for AtherosclerosisAnastasia V. Poznyak0Larisa Litvinova1Paolo Poggio2Alexander N. Orekhov3Alexandra A. Melnichenko4Institute for Atherosclerosis Research, Osennyaya 4-1-207, Moscow 121609, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 6 Gaidara Street, Kaliningrad 236001, RussiaUnit for Study of Aortic, Valvular and Coronary Pathologies, Centro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, ItalyInstitute for Atherosclerosis Research, Osennyaya 4-1-207, Moscow 121609, RussiaLaboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow 125315, RussiaLipid metabolism alterations are an important component of the pathogenesis of atherosclerosis. However, it is now clear that the atherogenesis process involves more than one mechanism, and more than one condition can predispose this condition. Multiple risk factors contribute to the atherosclerosis initiation and define its course. Familial hypercholesterolaemia is a disorder of lipid metabolism that often leads to atherosclerosis development. As is clear from the disease name, the hallmark is the increased levels of low-density lipoprotein cholesterol (LDL-C) in blood. This creates favourable conditions for atherogenesis. In this review, we briefly described the familial hypercholesterolaemia and summarized data on the relationship between familial hypercholesterolaemia and atherosclerosis.https://www.mdpi.com/2227-9059/10/10/2639lipidcholesterolhypercholesterolaemiaatherosclerosis |
| spellingShingle | Anastasia V. Poznyak Larisa Litvinova Paolo Poggio Alexander N. Orekhov Alexandra A. Melnichenko Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis Biomedicines lipid cholesterol hypercholesterolaemia atherosclerosis |
| title | Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis |
| title_full | Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis |
| title_fullStr | Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis |
| title_full_unstemmed | Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis |
| title_short | Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis |
| title_sort | familial hypercholesterolaemia as a predisposing factor for atherosclerosis |
| topic | lipid cholesterol hypercholesterolaemia atherosclerosis |
| url | https://www.mdpi.com/2227-9059/10/10/2639 |
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