Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the Diagnosis
Mycophenolate mofetil (CellCept®), a commonly used immunosuppressive drug in solid organ transplantation, has recently been shown to cause graft-versus-host disease (GVHD)-like changes in the gastrointestinal tract. On rare occasions, true GVHD has also been documented in the gastrointestinal tract...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2009-12-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/260903 |
| _version_ | 1819231127423942656 |
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| author | Kathryn C. Behling Dorothy M.J. Foster Tina B. Edmonston Agnieszka K. Witkiewicz |
| author_facet | Kathryn C. Behling Dorothy M.J. Foster Tina B. Edmonston Agnieszka K. Witkiewicz |
| author_sort | Kathryn C. Behling |
| collection | DOAJ |
| description | Mycophenolate mofetil (CellCept®), a commonly used immunosuppressive drug in solid organ transplantation, has recently been shown to cause graft-versus-host disease (GVHD)-like changes in the gastrointestinal tract. On rare occasions, true GVHD has also been documented in the gastrointestinal tract of solid organ transplant patients. Because the treatment for these two entities is different, i.e. removal of the offending agent versus the administration of steroids, proper identification of the cause is imperative. We present a case of mycophenolate mofetil colitis mimicking grade I GVHD of the gut. In our study, we used fluorescence in situ hybridization for the Y chromosome to document the lack of male donor lymphocytes in the female recipient colon biopsy. We suggest that molecular techniques including fluorescence in situ hybridization could be used to discriminate between MMF-related colitis and true GVHD in order to help guide therapy. |
| first_indexed | 2024-12-23T11:40:01Z |
| format | Article |
| id | doaj.art-5fdfc39565604142a0dc4c89d3d421f2 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-23T11:40:01Z |
| publishDate | 2009-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-5fdfc39565604142a0dc4c89d3d421f22022-12-21T17:48:31ZengKarger PublishersCase Reports in Gastroenterology1662-06312009-12-013341842310.1159/000260903260903Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the DiagnosisKathryn C. BehlingDorothy M.J. FosterTina B. EdmonstonAgnieszka K. WitkiewiczMycophenolate mofetil (CellCept®), a commonly used immunosuppressive drug in solid organ transplantation, has recently been shown to cause graft-versus-host disease (GVHD)-like changes in the gastrointestinal tract. On rare occasions, true GVHD has also been documented in the gastrointestinal tract of solid organ transplant patients. Because the treatment for these two entities is different, i.e. removal of the offending agent versus the administration of steroids, proper identification of the cause is imperative. We present a case of mycophenolate mofetil colitis mimicking grade I GVHD of the gut. In our study, we used fluorescence in situ hybridization for the Y chromosome to document the lack of male donor lymphocytes in the female recipient colon biopsy. We suggest that molecular techniques including fluorescence in situ hybridization could be used to discriminate between MMF-related colitis and true GVHD in order to help guide therapy.http://www.karger.com/Article/FullText/260903ColitisMycophenolate mofetilGraft-versus-host diseaseFluorescence in situ hybridizationHeart transplantation |
| spellingShingle | Kathryn C. Behling Dorothy M.J. Foster Tina B. Edmonston Agnieszka K. Witkiewicz Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the Diagnosis Case Reports in Gastroenterology Colitis Mycophenolate mofetil Graft-versus-host disease Fluorescence in situ hybridization Heart transplantation |
| title | Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the Diagnosis |
| title_full | Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the Diagnosis |
| title_fullStr | Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the Diagnosis |
| title_full_unstemmed | Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the Diagnosis |
| title_short | Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the Diagnosis |
| title_sort | graft versus host disease like pattern in mycophenolate mofetil related colon mucosal injury role of fish in establishing the diagnosis |
| topic | Colitis Mycophenolate mofetil Graft-versus-host disease Fluorescence in situ hybridization Heart transplantation |
| url | http://www.karger.com/Article/FullText/260903 |
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