Recent Advances in Bacterial Persistence Mechanisms
The recurrence of bacterial infectious diseases is closely associated with bacterial persisters. This subpopulation of bacteria can escape antibiotic treatment by entering a metabolic status of low activity through various mechanisms, for example, biofilm, toxin–antitoxin modules, the stringent resp...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14311 |
| _version_ | 1797579579770011648 |
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| author | Xiaozhou Pan Wenxin Liu Qingqing Du Hong Zhang Dingding Han |
| author_facet | Xiaozhou Pan Wenxin Liu Qingqing Du Hong Zhang Dingding Han |
| author_sort | Xiaozhou Pan |
| collection | DOAJ |
| description | The recurrence of bacterial infectious diseases is closely associated with bacterial persisters. This subpopulation of bacteria can escape antibiotic treatment by entering a metabolic status of low activity through various mechanisms, for example, biofilm, toxin–antitoxin modules, the stringent response, and the SOS response. Correspondingly, multiple new treatments are being developed. However, due to their spontaneous low abundance in populations and the lack of research on in vivo interactions between persisters and the host’s immune system, microfluidics, high-throughput sequencing, and microscopy techniques are combined innovatively to explore the mechanisms of persister formation and maintenance at the single-cell level. Here, we outline the main mechanisms of persister formation, and describe the cutting-edge technology for further research. Despite the significant progress regarding study techniques, some challenges remain to be tackled. |
| first_indexed | 2024-03-10T22:39:09Z |
| format | Article |
| id | doaj.art-5fe0ed1733a947dba7d076d9212b10a7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:39:09Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5fe0ed1733a947dba7d076d9212b10a72023-11-19T11:10:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181431110.3390/ijms241814311Recent Advances in Bacterial Persistence MechanismsXiaozhou Pan0Wenxin Liu1Qingqing Du2Hong Zhang3Dingding Han4Department of Clinical Laboratory, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, ChinaDepartment of Clinical Laboratory, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, ChinaDepartment of Clinical Laboratory, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, ChinaDepartment of Clinical Laboratory, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, ChinaDepartment of Clinical Laboratory, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, ChinaThe recurrence of bacterial infectious diseases is closely associated with bacterial persisters. This subpopulation of bacteria can escape antibiotic treatment by entering a metabolic status of low activity through various mechanisms, for example, biofilm, toxin–antitoxin modules, the stringent response, and the SOS response. Correspondingly, multiple new treatments are being developed. However, due to their spontaneous low abundance in populations and the lack of research on in vivo interactions between persisters and the host’s immune system, microfluidics, high-throughput sequencing, and microscopy techniques are combined innovatively to explore the mechanisms of persister formation and maintenance at the single-cell level. Here, we outline the main mechanisms of persister formation, and describe the cutting-edge technology for further research. Despite the significant progress regarding study techniques, some challenges remain to be tackled.https://www.mdpi.com/1422-0067/24/18/14311bacterial persistencepersister formationsingle-cell techniques |
| spellingShingle | Xiaozhou Pan Wenxin Liu Qingqing Du Hong Zhang Dingding Han Recent Advances in Bacterial Persistence Mechanisms International Journal of Molecular Sciences bacterial persistence persister formation single-cell techniques |
| title | Recent Advances in Bacterial Persistence Mechanisms |
| title_full | Recent Advances in Bacterial Persistence Mechanisms |
| title_fullStr | Recent Advances in Bacterial Persistence Mechanisms |
| title_full_unstemmed | Recent Advances in Bacterial Persistence Mechanisms |
| title_short | Recent Advances in Bacterial Persistence Mechanisms |
| title_sort | recent advances in bacterial persistence mechanisms |
| topic | bacterial persistence persister formation single-cell techniques |
| url | https://www.mdpi.com/1422-0067/24/18/14311 |
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