Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer’s disease
GABAergic inhibitory neurons are the principal source of inhibition in the brain. Traditionally, their role in maintaining the balance of excitation-inhibition has been emphasized. Beyond homeostatic functions, recent circuit mapping and functional manipulation studies have revealed a wide range of...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2023.1223891/full |
| _version_ | 1797670786248474624 |
|---|---|
| author | Melissa Hernández-Frausto Melissa Hernández-Frausto Olesia M. Bilash Olesia M. Bilash Arjun V. Masurkar Arjun V. Masurkar Arjun V. Masurkar Jayeeta Basu Jayeeta Basu Jayeeta Basu Jayeeta Basu |
| author_facet | Melissa Hernández-Frausto Melissa Hernández-Frausto Olesia M. Bilash Olesia M. Bilash Arjun V. Masurkar Arjun V. Masurkar Arjun V. Masurkar Jayeeta Basu Jayeeta Basu Jayeeta Basu Jayeeta Basu |
| author_sort | Melissa Hernández-Frausto |
| collection | DOAJ |
| description | GABAergic inhibitory neurons are the principal source of inhibition in the brain. Traditionally, their role in maintaining the balance of excitation-inhibition has been emphasized. Beyond homeostatic functions, recent circuit mapping and functional manipulation studies have revealed a wide range of specific roles that GABAergic circuits play in dynamically tilting excitation-inhibition coupling across spatio-temporal scales. These span from gating of compartment- and input-specific signaling, gain modulation, shaping input–output functions and synaptic plasticity, to generating signal-to-noise contrast, defining temporal windows for integration and rate codes, as well as organizing neural assemblies, and coordinating inter-regional synchrony. GABAergic circuits are thus instrumental in controlling single-neuron computations and behaviorally-linked network activity. The activity dependent modulation of sensory and mnemonic information processing by GABAergic circuits is pivotal for the formation and maintenance of episodic memories in the hippocampus. Here, we present an overview of the local and long-range GABAergic circuits that modulate the dynamics of excitation-inhibition and disinhibition in the main output area of the hippocampus CA1, which is crucial for episodic memory. Specifically, we link recent findings pertaining to GABAergic neuron molecular markers, electrophysiological properties, and synaptic wiring with their function at the circuit level. Lastly, given that area CA1 is particularly impaired during early stages of Alzheimer’s disease, we emphasize how these GABAergic circuits may contribute to and be involved in the pathophysiology. |
| first_indexed | 2024-03-11T21:05:39Z |
| format | Article |
| id | doaj.art-5fe3c6bf96914e8589e6f410698ee804 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-03-11T21:05:39Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-5fe3c6bf96914e8589e6f410698ee8042023-09-29T13:46:48ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102023-09-011710.3389/fncir.2023.12238911223891Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer’s diseaseMelissa Hernández-Frausto0Melissa Hernández-Frausto1Olesia M. Bilash2Olesia M. Bilash3Arjun V. Masurkar4Arjun V. Masurkar5Arjun V. Masurkar6Jayeeta Basu7Jayeeta Basu8Jayeeta Basu9Jayeeta Basu10Neuroscience Institute, New York University Langone Health, New York, NY, United StatesDepartment of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, United StatesNeuroscience Institute, New York University Langone Health, New York, NY, United StatesMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United StatesNeuroscience Institute, New York University Langone Health, New York, NY, United StatesDepartment of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, United StatesCenter for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, NY, United StatesNeuroscience Institute, New York University Langone Health, New York, NY, United StatesDepartment of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, United StatesDepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY, United StatesCenter for Neural Science, New York University, New York, NY, United StatesGABAergic inhibitory neurons are the principal source of inhibition in the brain. Traditionally, their role in maintaining the balance of excitation-inhibition has been emphasized. Beyond homeostatic functions, recent circuit mapping and functional manipulation studies have revealed a wide range of specific roles that GABAergic circuits play in dynamically tilting excitation-inhibition coupling across spatio-temporal scales. These span from gating of compartment- and input-specific signaling, gain modulation, shaping input–output functions and synaptic plasticity, to generating signal-to-noise contrast, defining temporal windows for integration and rate codes, as well as organizing neural assemblies, and coordinating inter-regional synchrony. GABAergic circuits are thus instrumental in controlling single-neuron computations and behaviorally-linked network activity. The activity dependent modulation of sensory and mnemonic information processing by GABAergic circuits is pivotal for the formation and maintenance of episodic memories in the hippocampus. Here, we present an overview of the local and long-range GABAergic circuits that modulate the dynamics of excitation-inhibition and disinhibition in the main output area of the hippocampus CA1, which is crucial for episodic memory. Specifically, we link recent findings pertaining to GABAergic neuron molecular markers, electrophysiological properties, and synaptic wiring with their function at the circuit level. Lastly, given that area CA1 is particularly impaired during early stages of Alzheimer’s disease, we emphasize how these GABAergic circuits may contribute to and be involved in the pathophysiology.https://www.frontiersin.org/articles/10.3389/fncir.2023.1223891/fullGABAergic circuitsAlzheimer’s diseasehippocampus (CA1)long-range GABAergic neuronsdisinhibition |
| spellingShingle | Melissa Hernández-Frausto Melissa Hernández-Frausto Olesia M. Bilash Olesia M. Bilash Arjun V. Masurkar Arjun V. Masurkar Arjun V. Masurkar Jayeeta Basu Jayeeta Basu Jayeeta Basu Jayeeta Basu Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer’s disease Frontiers in Neural Circuits GABAergic circuits Alzheimer’s disease hippocampus (CA1) long-range GABAergic neurons disinhibition |
| title | Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer’s disease |
| title_full | Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer’s disease |
| title_fullStr | Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer’s disease |
| title_full_unstemmed | Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer’s disease |
| title_short | Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer’s disease |
| title_sort | local and long range gabaergic circuits in hippocampal area ca1 and their link to alzheimer s disease |
| topic | GABAergic circuits Alzheimer’s disease hippocampus (CA1) long-range GABAergic neurons disinhibition |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2023.1223891/full |
| work_keys_str_mv | AT melissahernandezfrausto localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease AT melissahernandezfrausto localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease AT olesiambilash localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease AT olesiambilash localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease AT arjunvmasurkar localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease AT arjunvmasurkar localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease AT arjunvmasurkar localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease AT jayeetabasu localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease AT jayeetabasu localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease AT jayeetabasu localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease AT jayeetabasu localandlongrangegabaergiccircuitsinhippocampalareaca1andtheirlinktoalzheimersdisease |