A network of genes, genetic disorders, and brain areas.
The network-based approach has been used to describe the relationship among genes and various phenotypes, producing a network describing complex biological relationships. Such networks can be constructed by aggregating previously reported associations in the literature from various databases. In thi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3112220?pdf=render |
| _version_ | 1818962228023394304 |
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| author | Satoru Hayasaka Christina E Hugenschmidt Paul J Laurienti |
| author_facet | Satoru Hayasaka Christina E Hugenschmidt Paul J Laurienti |
| author_sort | Satoru Hayasaka |
| collection | DOAJ |
| description | The network-based approach has been used to describe the relationship among genes and various phenotypes, producing a network describing complex biological relationships. Such networks can be constructed by aggregating previously reported associations in the literature from various databases. In this work, we applied the network-based approach to investigate how different brain areas are associated to genetic disorders and genes. In particular, a tripartite network with genes, genetic diseases, and brain areas was constructed based on the associations among them reported in the literature through text mining. In the resulting network, a disproportionately large number of gene-disease and disease-brain associations were attributed to a small subset of genes, diseases, and brain areas. Furthermore, a small number of brain areas were found to be associated with a large number of the same genes and diseases. These core brain regions encompassed the areas identified by the previous genome-wide association studies, and suggest potential areas of focus in the future imaging genetics research. The approach outlined in this work demonstrates the utility of the network-based approach in studying genetic effects on the brain. |
| first_indexed | 2024-12-20T12:25:59Z |
| format | Article |
| id | doaj.art-5fe5a51169b549c8aa54343d83fbdca3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T12:25:59Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5fe5a51169b549c8aa54343d83fbdca32022-12-21T19:40:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0166e2090710.1371/journal.pone.0020907A network of genes, genetic disorders, and brain areas.Satoru HayasakaChristina E HugenschmidtPaul J LaurientiThe network-based approach has been used to describe the relationship among genes and various phenotypes, producing a network describing complex biological relationships. Such networks can be constructed by aggregating previously reported associations in the literature from various databases. In this work, we applied the network-based approach to investigate how different brain areas are associated to genetic disorders and genes. In particular, a tripartite network with genes, genetic diseases, and brain areas was constructed based on the associations among them reported in the literature through text mining. In the resulting network, a disproportionately large number of gene-disease and disease-brain associations were attributed to a small subset of genes, diseases, and brain areas. Furthermore, a small number of brain areas were found to be associated with a large number of the same genes and diseases. These core brain regions encompassed the areas identified by the previous genome-wide association studies, and suggest potential areas of focus in the future imaging genetics research. The approach outlined in this work demonstrates the utility of the network-based approach in studying genetic effects on the brain.http://europepmc.org/articles/PMC3112220?pdf=render |
| spellingShingle | Satoru Hayasaka Christina E Hugenschmidt Paul J Laurienti A network of genes, genetic disorders, and brain areas. PLoS ONE |
| title | A network of genes, genetic disorders, and brain areas. |
| title_full | A network of genes, genetic disorders, and brain areas. |
| title_fullStr | A network of genes, genetic disorders, and brain areas. |
| title_full_unstemmed | A network of genes, genetic disorders, and brain areas. |
| title_short | A network of genes, genetic disorders, and brain areas. |
| title_sort | network of genes genetic disorders and brain areas |
| url | http://europepmc.org/articles/PMC3112220?pdf=render |
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