Role of γδ T cells in mucosal intranet
Intraepithelial γδ T cells appear to be an essential regulatory T cell subset for the induction and regulation of humoral and cellular immune responses in the mucosa-associated tissues. These cells form a mucosal internet and intranet with epithelial cells which lead to a reciprocal regulation for a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
1999-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015314611 |
| _version_ | 1819012391612973056 |
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| author | Masafumi Yamamoto Hiroshi Kiyono |
| author_facet | Masafumi Yamamoto Hiroshi Kiyono |
| author_sort | Masafumi Yamamoto |
| collection | DOAJ |
| description | Intraepithelial γδ T cells appear to be an essential regulatory T cell subset for the induction and regulation of humoral and cellular immune responses in the mucosa-associated tissues. These cells form a mucosal internet and intranet with epithelial cells which lead to a reciprocal regulation for activation and cell growth. Removal of the TORS gene (γδ-/- mice) results in a reduction of epithelial cell turnover and downregulates the expression of major histocompatibility complex class II molecules on epithelial cells. Epithelial cells are capable of producing interleukin (IL)-7 and stem cell factor which can activate mucosal γδ T cells expressing IL-7R and c-kit. Further, cell surface immunoregulatory molecules expressed on epithelial cells inhibit the proliferation and cytokine synthesis of γδ T cells stimulated via the TOR-OD3 complex. Thus, direct cell-to-cell interactions between mucosal γδ T cells and epithelial cells occur via their secreted cytokines and their cell surface immunoregulatory molecules to maintain the homeostatic regulation of the mucosal immune system. γδ-/- mice possess significantly lower numbers of immunoglobulin A (IgA) producing cells in mucosa- associated tissues, including intestinal lamina propria and salivary glands, when compared with normal control mice. Furthermore, the levels of antigen- specific IgA B cell responses in γδ-/- mice decreased when they were immunized orally. Mucosal γδ T cells possess an ability to maintain an IgA response in the presence of systemic tolerance. These results clearly indicate that γδ T cells play an important role in the regulation of antigen-specific mucosal IgA responses. Taken together, a triad mucosal lymphocytes intranet which connects among γδ T cells, αβ T cells and IgA B cells is necessary for the induction and regulation of IgA antibody responses in mucosal areas. |
| first_indexed | 2024-12-21T01:43:19Z |
| format | Article |
| id | doaj.art-5fe6f1c8a5e549378533585e50e4c9c0 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-21T01:43:19Z |
| publishDate | 1999-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-5fe6f1c8a5e549378533585e50e4c9c02022-12-21T19:20:05ZengElsevierAllergology International1323-89301999-01-014811510.1046/j.1440-1592.1999.00110.xRole of γδ T cells in mucosal intranetMasafumi Yamamoto0Hiroshi Kiyono1Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, JapanDepartment of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, JapanIntraepithelial γδ T cells appear to be an essential regulatory T cell subset for the induction and regulation of humoral and cellular immune responses in the mucosa-associated tissues. These cells form a mucosal internet and intranet with epithelial cells which lead to a reciprocal regulation for activation and cell growth. Removal of the TORS gene (γδ-/- mice) results in a reduction of epithelial cell turnover and downregulates the expression of major histocompatibility complex class II molecules on epithelial cells. Epithelial cells are capable of producing interleukin (IL)-7 and stem cell factor which can activate mucosal γδ T cells expressing IL-7R and c-kit. Further, cell surface immunoregulatory molecules expressed on epithelial cells inhibit the proliferation and cytokine synthesis of γδ T cells stimulated via the TOR-OD3 complex. Thus, direct cell-to-cell interactions between mucosal γδ T cells and epithelial cells occur via their secreted cytokines and their cell surface immunoregulatory molecules to maintain the homeostatic regulation of the mucosal immune system. γδ-/- mice possess significantly lower numbers of immunoglobulin A (IgA) producing cells in mucosa- associated tissues, including intestinal lamina propria and salivary glands, when compared with normal control mice. Furthermore, the levels of antigen- specific IgA B cell responses in γδ-/- mice decreased when they were immunized orally. Mucosal γδ T cells possess an ability to maintain an IgA response in the presence of systemic tolerance. These results clearly indicate that γδ T cells play an important role in the regulation of antigen-specific mucosal IgA responses. Taken together, a triad mucosal lymphocytes intranet which connects among γδ T cells, αβ T cells and IgA B cells is necessary for the induction and regulation of IgA antibody responses in mucosal areas.http://www.sciencedirect.com/science/article/pii/S1323893015314611γδ T cellsepithelial cellsmucosal intranetγδ-/- mice |
| spellingShingle | Masafumi Yamamoto Hiroshi Kiyono Role of γδ T cells in mucosal intranet Allergology International γδ T cells epithelial cells mucosal intranet γδ-/- mice |
| title | Role of γδ T cells in mucosal intranet |
| title_full | Role of γδ T cells in mucosal intranet |
| title_fullStr | Role of γδ T cells in mucosal intranet |
| title_full_unstemmed | Role of γδ T cells in mucosal intranet |
| title_short | Role of γδ T cells in mucosal intranet |
| title_sort | role of γδ t cells in mucosal intranet |
| topic | γδ T cells epithelial cells mucosal intranet γδ-/- mice |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015314611 |
| work_keys_str_mv | AT masafumiyamamoto roleofgdtcellsinmucosalintranet AT hiroshikiyono roleofgdtcellsinmucosalintranet |