Implementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance
Abstract Background There is substantial evidence to support the use of several methods for preventing deep-vein thrombosis (DVT) following intracerebral hemorrhage (ICH). However, the extent to which these measures are implemented in clinical practice and the factors influencing patients’ receipt o...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12959-024-00592-w |
| _version_ | 1797273528018403328 |
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| author | Ran Zhang Weige Sun Yana Xing Yongjun Wang Zixiao Li Liping Liu Hongqiu Gu Kaixuan Yang Xin Yang Chunjuan Wang Qingbo Liu Qian Xiao Weixin Cai |
| author_facet | Ran Zhang Weige Sun Yana Xing Yongjun Wang Zixiao Li Liping Liu Hongqiu Gu Kaixuan Yang Xin Yang Chunjuan Wang Qingbo Liu Qian Xiao Weixin Cai |
| author_sort | Ran Zhang |
| collection | DOAJ |
| description | Abstract Background There is substantial evidence to support the use of several methods for preventing deep-vein thrombosis (DVT) following intracerebral hemorrhage (ICH). However, the extent to which these measures are implemented in clinical practice and the factors influencing patients’ receipt of preventive measures remain unclear. Therefore, we aimed to evaluate the rate of the early implementation of DVT prophylaxis and the factors associated with its success in patients with ICH. Methods This study enrolled 49,950 patients with spontaneous ICH from the Chinese Stroke Center Alliance (CSCA) between August 2015 and July 2019. Early DVT prophylaxis implementation was defined as an intervention occurring within 48 h after admission. Univariate and multivariate logistic regression analyses were conducted to identify the rate and factors associated with the implementation of early prophylaxis for DVT in patients with ICH. Results Among the 49,950 ICH patients, the rate of early DVT prophylaxis implementation was 49.9%, the rate of early mobilization implementation was 29.49%, and that of pharmacological prophylaxis was 2.02%. Factors associated with an increased likelihood of early DVT prophylaxis being administered in the multivariable model included receiving early rehabilitation therapy (odds ratio [OR], 2.531); admission to stroke unit (OR 2.231); admission to intensive care unit (OR 1.975); being located in central (OR 1.879) or eastern regions (OR 1.529); having a history of chronic obstructive pulmonary disease (OR 1.292), ischemic stroke (OR 1.245), coronary heart disease or myocardial infarction (OR 1.2); taking antihypertensive drugs (OR 1.136); and having a higher Glasgow Coma Scale (GCS) score (OR 1.045). Conversely, being male (OR 0.936), being hospitalized in tertiary hospitals (OR 0.778), and having a previous intracranial hemorrhage (OR 0.733) were associated with a lower likelihood of early DVT prophylaxis being administered in patients with ICH. Conclusions The implementation rate of early DVT prophylaxis among Chinese patients with ICH was subpar, with pharmacological prophylaxis showing the lowest prevalence. Various controllable factors exerted an impact on the implementation of early DVT prophylaxis in this population. |
| first_indexed | 2024-03-07T14:45:39Z |
| format | Article |
| id | doaj.art-5fe78157745948fdb7758c16814599c1 |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-03-07T14:45:39Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-5fe78157745948fdb7758c16814599c12024-03-05T20:00:16ZengBMCThrombosis Journal1477-95602024-02-012211810.1186/s12959-024-00592-wImplementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center AllianceRan Zhang0Weige Sun1Yana Xing2Yongjun Wang3Zixiao Li4Liping Liu5Hongqiu Gu6Kaixuan Yang7Xin Yang8Chunjuan Wang9Qingbo Liu10Qian Xiao11Weixin Cai12Nursing Department, Beijing Tiantan Hospital, Capital Medical UniversityNursing Department, Beijing Tiantan Hospital, Capital Medical UniversityNursing Department, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityChina National Clinical Research Center for Neurological DiseasesChina National Clinical Research Center for Neurological DiseasesDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityNursing Department, Beijing Tiantan Hospital, Capital Medical UniversitySchool of Nursing, Capital Medical UniversityNursing Department, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background There is substantial evidence to support the use of several methods for preventing deep-vein thrombosis (DVT) following intracerebral hemorrhage (ICH). However, the extent to which these measures are implemented in clinical practice and the factors influencing patients’ receipt of preventive measures remain unclear. Therefore, we aimed to evaluate the rate of the early implementation of DVT prophylaxis and the factors associated with its success in patients with ICH. Methods This study enrolled 49,950 patients with spontaneous ICH from the Chinese Stroke Center Alliance (CSCA) between August 2015 and July 2019. Early DVT prophylaxis implementation was defined as an intervention occurring within 48 h after admission. Univariate and multivariate logistic regression analyses were conducted to identify the rate and factors associated with the implementation of early prophylaxis for DVT in patients with ICH. Results Among the 49,950 ICH patients, the rate of early DVT prophylaxis implementation was 49.9%, the rate of early mobilization implementation was 29.49%, and that of pharmacological prophylaxis was 2.02%. Factors associated with an increased likelihood of early DVT prophylaxis being administered in the multivariable model included receiving early rehabilitation therapy (odds ratio [OR], 2.531); admission to stroke unit (OR 2.231); admission to intensive care unit (OR 1.975); being located in central (OR 1.879) or eastern regions (OR 1.529); having a history of chronic obstructive pulmonary disease (OR 1.292), ischemic stroke (OR 1.245), coronary heart disease or myocardial infarction (OR 1.2); taking antihypertensive drugs (OR 1.136); and having a higher Glasgow Coma Scale (GCS) score (OR 1.045). Conversely, being male (OR 0.936), being hospitalized in tertiary hospitals (OR 0.778), and having a previous intracranial hemorrhage (OR 0.733) were associated with a lower likelihood of early DVT prophylaxis being administered in patients with ICH. Conclusions The implementation rate of early DVT prophylaxis among Chinese patients with ICH was subpar, with pharmacological prophylaxis showing the lowest prevalence. Various controllable factors exerted an impact on the implementation of early DVT prophylaxis in this population.https://doi.org/10.1186/s12959-024-00592-wDeep-vein thrombosisIntracerebral hemorrhageEarly prophylaxisFactorsChinese stroke center alliance |
| spellingShingle | Ran Zhang Weige Sun Yana Xing Yongjun Wang Zixiao Li Liping Liu Hongqiu Gu Kaixuan Yang Xin Yang Chunjuan Wang Qingbo Liu Qian Xiao Weixin Cai Implementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance Thrombosis Journal Deep-vein thrombosis Intracerebral hemorrhage Early prophylaxis Factors Chinese stroke center alliance |
| title | Implementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance |
| title_full | Implementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance |
| title_fullStr | Implementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance |
| title_full_unstemmed | Implementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance |
| title_short | Implementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance |
| title_sort | implementation of early prophylaxis for deep vein thrombosis in intracerebral hemorrhage patients an observational study from the chinese stroke center alliance |
| topic | Deep-vein thrombosis Intracerebral hemorrhage Early prophylaxis Factors Chinese stroke center alliance |
| url | https://doi.org/10.1186/s12959-024-00592-w |
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