Analysis of Cerebrospinal Fluid in Diagnosis of Bacterial Meningitis; Using Nuclear Magnetic Resonance Spectroscopy: A Systematic Review
Background: Analysis of biofluids provides a unique window into the biochemical status of a living organism since the composition of a given biofluid will be modulated according to the level of function of the cells that are intimately concerned with its manufacture and secretion. One of the most su...
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| Format: | Article |
| Language: | English |
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Guilan University of Medical Sciences
2017-08-01
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| Series: | Caspian Journal of Neurological Sciences |
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| Online Access: | http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-82&slc_lang=en&sid=1 |
| _version_ | 1811259596110561280 |
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| author | Alia Saberi Seyed-Ali Roudbary Mohamadreza Emamhadi Samaneh Kazemi |
| author_facet | Alia Saberi Seyed-Ali Roudbary Mohamadreza Emamhadi Samaneh Kazemi |
| author_sort | Alia Saberi |
| collection | DOAJ |
| description | Background: Analysis of biofluids provides a unique window into the biochemical status of a living organism since the composition of a given biofluid will be modulated according to the level of function of the cells that are intimately concerned with its manufacture and secretion. One of the most successful approaches to biofluid analysis has been the application of NMR spectroscopy.
Objectives: The aim of this study was the survey of the role of Nuclear Magnetic Resonance (NMR) Spectroscopy in differential diagnosis of septic bacterial meningitis.
Methods: Using the search strategy from three databases (MEDLINE/PMC, Web of Science, Scopus), list of references of selected articles and gray literature, without time and language limitation, articles up to March 2017 were entered into this review. In this review, 219 articles were acquired at the primary search. Study selection and quality assessment processes were done based on Cochrane library guidelines. After assessing the quality and inclusion and exclusion criteria, 4 articles were selected and entered into the data synthesis.
Results: The results of 4 studies demonstrated relative elevation of lactate value and extracellular acidosis in bacterial meningitis not in aseptic meningitis. Moreover in most of them, decreasing its level by treatment was evident.
Conclusion: Metabolomic analysis with NMR spectroscopy of cerebrospinal fluid can become a powerful helping in differentiation of septic meningitis from aseptic meningitis. |
| first_indexed | 2024-04-12T18:34:03Z |
| format | Article |
| id | doaj.art-5fe7cd5da230424ea6676ee42f330f18 |
| institution | Directory Open Access Journal |
| issn | 2383-4307 2423-4818 |
| language | English |
| last_indexed | 2024-04-12T18:34:03Z |
| publishDate | 2017-08-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj.art-5fe7cd5da230424ea6676ee42f330f182022-12-22T03:21:00ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2383-43072423-48182017-08-01310159168Analysis of Cerebrospinal Fluid in Diagnosis of Bacterial Meningitis; Using Nuclear Magnetic Resonance Spectroscopy: A Systematic ReviewAlia Saberi0Seyed-Ali Roudbary1Mohamadreza Emamhadi2Samaneh Kazemi3 Neuroscience Research Center, Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Neurology Department, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Brachial Plexus and Peripheral Nerve Injury Center, Guilan University of Medical Science, Rasht, Iran Microbiologist, Vice-Chancellor of Research and Technology, Guilan University of Medical Sciences, Rasht, Iran; kazemi_s@gums.ac.ir Background: Analysis of biofluids provides a unique window into the biochemical status of a living organism since the composition of a given biofluid will be modulated according to the level of function of the cells that are intimately concerned with its manufacture and secretion. One of the most successful approaches to biofluid analysis has been the application of NMR spectroscopy. Objectives: The aim of this study was the survey of the role of Nuclear Magnetic Resonance (NMR) Spectroscopy in differential diagnosis of septic bacterial meningitis. Methods: Using the search strategy from three databases (MEDLINE/PMC, Web of Science, Scopus), list of references of selected articles and gray literature, without time and language limitation, articles up to March 2017 were entered into this review. In this review, 219 articles were acquired at the primary search. Study selection and quality assessment processes were done based on Cochrane library guidelines. After assessing the quality and inclusion and exclusion criteria, 4 articles were selected and entered into the data synthesis. Results: The results of 4 studies demonstrated relative elevation of lactate value and extracellular acidosis in bacterial meningitis not in aseptic meningitis. Moreover in most of them, decreasing its level by treatment was evident. Conclusion: Metabolomic analysis with NMR spectroscopy of cerebrospinal fluid can become a powerful helping in differentiation of septic meningitis from aseptic meningitis.http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-82&slc_lang=en&sid=1MetabolomicsMagnetic Resonance SpectroscopyMeningitisBacterial |
| spellingShingle | Alia Saberi Seyed-Ali Roudbary Mohamadreza Emamhadi Samaneh Kazemi Analysis of Cerebrospinal Fluid in Diagnosis of Bacterial Meningitis; Using Nuclear Magnetic Resonance Spectroscopy: A Systematic Review Caspian Journal of Neurological Sciences Metabolomics Magnetic Resonance Spectroscopy Meningitis Bacterial |
| title | Analysis of Cerebrospinal Fluid in Diagnosis of Bacterial Meningitis; Using Nuclear Magnetic Resonance Spectroscopy:
A Systematic Review |
| title_full | Analysis of Cerebrospinal Fluid in Diagnosis of Bacterial Meningitis; Using Nuclear Magnetic Resonance Spectroscopy:
A Systematic Review |
| title_fullStr | Analysis of Cerebrospinal Fluid in Diagnosis of Bacterial Meningitis; Using Nuclear Magnetic Resonance Spectroscopy:
A Systematic Review |
| title_full_unstemmed | Analysis of Cerebrospinal Fluid in Diagnosis of Bacterial Meningitis; Using Nuclear Magnetic Resonance Spectroscopy:
A Systematic Review |
| title_short | Analysis of Cerebrospinal Fluid in Diagnosis of Bacterial Meningitis; Using Nuclear Magnetic Resonance Spectroscopy:
A Systematic Review |
| title_sort | analysis of cerebrospinal fluid in diagnosis of bacterial meningitis using nuclear magnetic resonance spectroscopy a systematic review |
| topic | Metabolomics Magnetic Resonance Spectroscopy Meningitis Bacterial |
| url | http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-82&slc_lang=en&sid=1 |
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