Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain metastases
Abstract Radiotherapy and targeted therapy are essential treatments for patients with brain metastases from human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, the combination of radiotherapy and targeted therapy still needs to be investigated, and neurotoxicity induced...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-022-00894-7 |
| _version_ | 1797946016338542592 |
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| author | Xiaojing Yang Hanru Ren Yi Xu Xue Peng Wenxi Yu Zan Shen |
| author_facet | Xiaojing Yang Hanru Ren Yi Xu Xue Peng Wenxi Yu Zan Shen |
| author_sort | Xiaojing Yang |
| collection | DOAJ |
| description | Abstract Radiotherapy and targeted therapy are essential treatments for patients with brain metastases from human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, the combination of radiotherapy and targeted therapy still needs to be investigated, and neurotoxicity induced by radiotherapy for brain metastases has also become an important issue of clinical concern. It remained unclear how to achieve the balance of efficacy and toxicity with the application of new radiotherapy techniques and new targeted therapy drugs. This article reviews the benefits and potential risk of combining radiotherapy and targeted therapy for HER2-positive breast cancer with brain metastases. |
| first_indexed | 2024-04-10T21:04:13Z |
| format | Article |
| id | doaj.art-5fe804a20973495bb458281b86df718d |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-10T21:04:13Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-5fe804a20973495bb458281b86df718d2023-01-22T12:07:58ZengBMCEuropean Journal of Medical Research2047-783X2023-01-0128111310.1186/s40001-022-00894-7Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain metastasesXiaojing Yang0Hanru Ren1Yi Xu2Xue Peng3Wenxi Yu4Zan Shen5Department of Oncology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Orthopedics, Pudong Medical Center, Shanghai Pudong Hospital, Fudan UniversityDepartment of Oncology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Oncology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Oncology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineAbstract Radiotherapy and targeted therapy are essential treatments for patients with brain metastases from human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, the combination of radiotherapy and targeted therapy still needs to be investigated, and neurotoxicity induced by radiotherapy for brain metastases has also become an important issue of clinical concern. It remained unclear how to achieve the balance of efficacy and toxicity with the application of new radiotherapy techniques and new targeted therapy drugs. This article reviews the benefits and potential risk of combining radiotherapy and targeted therapy for HER2-positive breast cancer with brain metastases.https://doi.org/10.1186/s40001-022-00894-7Breast cancerHuman epidermal growth factor receptor 2Brain metastasisRadiation therapyTargeted therapy |
| spellingShingle | Xiaojing Yang Hanru Ren Yi Xu Xue Peng Wenxi Yu Zan Shen Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain metastases European Journal of Medical Research Breast cancer Human epidermal growth factor receptor 2 Brain metastasis Radiation therapy Targeted therapy |
| title | Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain metastases |
| title_full | Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain metastases |
| title_fullStr | Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain metastases |
| title_full_unstemmed | Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain metastases |
| title_short | Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain metastases |
| title_sort | combination of radiotherapy and targeted therapy for her2 positive breast cancer brain metastases |
| topic | Breast cancer Human epidermal growth factor receptor 2 Brain metastasis Radiation therapy Targeted therapy |
| url | https://doi.org/10.1186/s40001-022-00894-7 |
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