Theoretical Framework for the Study of Genetic Diseases Caused by Dominant Alleles

Theoretical Framework for the Study of Genetic Diseases Caused by Dominant Alleles

We propose a theoretical basis for analyzing several features of genetic diseases caused by dominant alleles, including: disease prevalence, genotype penetrance, and the relationship between causal genotype frequency and disease frequency. In addition, we provide a theoretical framework for accurate...

Full description

Bibliographic Details
Main Authors:	Michael F. Roberts, Stephen E. Bricher
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	Life
Subjects:	genetic disease prevalence penetrance accurate diagnosis disease iceberg effect cumulative lifetime risk
Online Access:	https://www.mdpi.com/2075-1729/13/3/733

Similar Items

Epidemiology of Rare Hereditary Diseases in the European Part of Russia: Point and Cumulative Prevalence
by: Rena A. Zinchenko, et al.
Published: (2021-08-01)

Corrigendum: Epidemiology of rare hereditary diseases in the European part of Russia: Point and cumulative prevalence
by: Rena A. Zinchenko, et al.
Published: (2022-09-01)

Historical occurrence of Antarctic icebergs within mercantile shipping routes and the exceptional events of the 1890s
by: Robert Keith Headland, et al.

Grounding Event of Iceberg D28 and Its Interactions with Seabed Topography
by: Xuying Liu, et al.
Published: (2021-12-01)

Optimization Neuro Fuzzy Using Genetic Algorithm For Diagnose Typhoid Fever
by: Muhamad Nasrul Fata, et al.
Published: (2019-05-01)

Movement determination of the Ward Hunt Ice Shelf /
by: 459148 Dorrer, Egon, et al.
Published: (1972)

Quantifying dissolution rates of Antarctic icebergs in open water
by: Olav Orheim, et al.

Antibiotic resistance and pathogenicity assessment of various Gardnerella sp. strains in local China
by: Kundi Zhang, et al.
Published: (2022-09-01)

Iceberg utilization : proceedings/
by: 475211 International Conference and Workshops on Iceberg Utilization for Fresh Water Production Weather Modification, and other Applications, Iowa State University, 1977, et al.
Published: (1978)

Stigma associated with genetic testing for rare diseases—causes and recommendations
by: Gareth Baynam, et al.
Published: (2024-04-01)

Detection of subclinical paratuberculosis in dairy cattle in Egypt
by: Shehata I. Anwar, et al.
Published: (2024-01-01)

Rare genetic causes of meningitis and encephalitis
by: Jangsup Moon
Published: (2022-04-01)

Fragmentation theory reveals processes controlling iceberg size distributions
by: Jan Åström, et al.
Published: (2021-08-01)

Persistent overcut regions dominate the terminus morphology of a rapidly melting tidewater glacier
by: Nicole Abib, et al.
Published: (2023-04-01)

A New Eulerian Iceberg Module for Climate Studies
by: Olga Erokhina, et al.
Published: (2024-03-01)

Geographical distribution and volume of Antarctic icebergs derived from ship observation data
by: Yury A. Romanov, et al.
Published: (2017-04-01)

First record of the occurrence of sea ice in the Cordillera Darwin fjords (54°S), Chile
by: Charles Salame, et al.
Published: (2020-12-01)

A Simplified Method of Iceberg Hydrodynamic Parameter Prediction
by: Dmitry Nikushchenko, et al.
Published: (2023-05-01)

Cumulative Effect Assessment of Common Genetic Variants on Prostate Cancer: Preliminary Studies
by: Anca Gabriela Pavel, et al.
Published: (2022-10-01)

The epidemiological, clinical, and genetic characteristics of Parkinson’s disease (in case of Zheleznogorsk)
by: M. R. Sapronova, et al.
Published: (2014-12-01)

A comparative study on the prevalence of musculoskeletal complaints among musicians and non-musicians
by: Kok Laura M, et al.
Published: (2013-01-01)

Impacts of tidewater glacier advance on iceberg habitat
by: Lynn M. Kaluzienski, et al.
Published: (2023-04-01)

Quad-Polarimetric Multi-Scale Analysis of Icebergs in ALOS-2 SAR Data: A Comparison between Icebergs in West and East Greenland
by: Johnson Bailey, et al.
Published: (2020-06-01)

The 1789 Christmas Eve collision of the HMS Guardian with an iceberg in the southwest Indian Ocean
by: Seelye Martin
Published: (2022-09-01)

Antarctic iceberg distribution revealed through three decades of systematic ship-based observations in the SCAR International Iceberg Database
by: Olav Orheim, et al.
Published: (2023-06-01)

Formation, flow and break-up of ephemeral ice mélange at LeConte Glacier and Bay, Alaska
by: Jason M. Amundson, et al.
Published: (2020-08-01)

Patterns in glacial-earthquake activity around Greenland, 2011–13
by: KIRA G. OLSEN, et al.
Published: (2017-12-01)

Melt-under-cutting and buoyancy-driven calving from tidewater glaciers: new insights from discrete element and continuum model simulations
by: DOUGLAS I. BENN, et al.
Published: (2017-08-01)

On the potential of hand-held GPS tracking of fjord ice features for remote-sensing validation
by: Jean Negrel, et al.
Published: (2018-07-01)

Iceberg properties and distributions in three Greenlandic fjords using satellite imagery
by: Daniel J. Sulak, et al.
Published: (2017-04-01)

The life cycle of small- to medium-sized icebergs in the Amundsen Sea Embayment
by: Aleksandra K. Mazur, et al.
Published: (2019-08-01)

RELIABILITY OF SERIAL-PARALLEL NETWORKS VS RELIABILITY OF PARALLELSERIAL NETWORKS WITH CONSTANT NUMBERS OF SUB-NETWORKS AND UNITS
by: ANDRIEVSCHI-BAGRIN, Veronica, et al.
Published: (2022-12-01)

The Role of Listening Skills in Developing Communicative Competence: A Case Study in the Language Classroom
by: Naci Yildiz, et al.
Published: (2015-12-01)

Epidemiology of Wilson’s Disease and Pathogenic Variants of the <i>ATP7B</i> Gene Leading to Diversified Protein Disfunctions
by: Elena Vasilievna Ovchinnikova, et al.
Published: (2024-02-01)

High-Speed and Accurate Diagnosis of Gastrointestinal Disease: Learning on Endoscopy Images Using Lightweight Transformer with Local Feature Attention
by: Shibin Wu, et al.
Published: (2023-12-01)

Biomarkers in the Diagnosis of Endometrial Precancers. Molecular Characteristics, Candidate Immunohistochemical Markers, and Promising Results of Three-Marker Panel: Current Status and Future Directions
by: Shuang Niu, et al.
Published: (2024-03-01)

How genetics can help diagnosis and treatment in psychiatric conditions
by: B. Chaumette, et al.
Published: (2021-04-01)

Genetic pattern and penetrance of polycystic kidney disease in the Western region of Iraq
by: Louay Mohammed Alani
Published: (2012-06-01)

Comparison of Target Detectors to Identify Icebergs in Quad-Polarimetric L-Band Synthetic Aperture Radar Data
by: Johnson Bailey, et al.
Published: (2021-04-01)

Comparison of Antarctic iceberg observations by Cook in 1772–75, Halley in 1700, Bouvet in 1739 and Riou in 1789 with modern data
by: Seelye Martin, et al.
Published: (2023-08-01)