Cardiac vagal afferent neurotransmission in health and disease: review and knowledge gaps
The meticulous control of cardiac sympathetic and parasympathetic tone regulates all facets of cardiac function. This precise calibration of cardiac efferent innervation is dependent on sensory information that is relayed from the heart to the central nervous system. The vagus nerve, which contains...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1192188/full |
| _version_ | 1797809844848164864 |
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| author | Valerie Y. H. van Weperen Marmar Vaseghi Marmar Vaseghi |
| author_facet | Valerie Y. H. van Weperen Marmar Vaseghi Marmar Vaseghi |
| author_sort | Valerie Y. H. van Weperen |
| collection | DOAJ |
| description | The meticulous control of cardiac sympathetic and parasympathetic tone regulates all facets of cardiac function. This precise calibration of cardiac efferent innervation is dependent on sensory information that is relayed from the heart to the central nervous system. The vagus nerve, which contains vagal cardiac afferent fibers, carries sensory information to the brainstem. Vagal afferent signaling has been predominantly shown to increase parasympathetic efferent response and vagal tone. However, cardiac vagal afferent signaling appears to change after cardiac injury, though much remains unknown. Even though subsequent cardiac autonomic imbalance is characterized by sympathoexcitation and parasympathetic dysfunction, it remains unclear if, and to what extent, vagal afferent dysfunction is involved in the development of vagal withdrawal. This review aims to summarize the current understanding of cardiac vagal afferent signaling under in health and in the setting of cardiovascular disease, especially after myocardial infarction, and to highlight the knowledge gaps that remain to be addressed. |
| first_indexed | 2024-03-13T07:00:04Z |
| format | Article |
| id | doaj.art-5fea30965926479089e29d83c477d206 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T07:00:04Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-5fea30965926479089e29d83c477d2062023-06-07T04:42:18ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-06-011710.3389/fnins.2023.11921881192188Cardiac vagal afferent neurotransmission in health and disease: review and knowledge gapsValerie Y. H. van Weperen0Marmar Vaseghi1Marmar Vaseghi2Division of Cardiology, Department of Medicine, UCLA Cardiac Arrhythmia Center, Los Angeles, CA, United StatesDivision of Cardiology, Department of Medicine, UCLA Cardiac Arrhythmia Center, Los Angeles, CA, United StatesMolecular, Cellular, and Integrative Physiology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, United StatesThe meticulous control of cardiac sympathetic and parasympathetic tone regulates all facets of cardiac function. This precise calibration of cardiac efferent innervation is dependent on sensory information that is relayed from the heart to the central nervous system. The vagus nerve, which contains vagal cardiac afferent fibers, carries sensory information to the brainstem. Vagal afferent signaling has been predominantly shown to increase parasympathetic efferent response and vagal tone. However, cardiac vagal afferent signaling appears to change after cardiac injury, though much remains unknown. Even though subsequent cardiac autonomic imbalance is characterized by sympathoexcitation and parasympathetic dysfunction, it remains unclear if, and to what extent, vagal afferent dysfunction is involved in the development of vagal withdrawal. This review aims to summarize the current understanding of cardiac vagal afferent signaling under in health and in the setting of cardiovascular disease, especially after myocardial infarction, and to highlight the knowledge gaps that remain to be addressed.https://www.frontiersin.org/articles/10.3389/fnins.2023.1192188/fullautonomicvagusafferentcardiovascular diseaseparasympatheticmyocardial infarction |
| spellingShingle | Valerie Y. H. van Weperen Marmar Vaseghi Marmar Vaseghi Cardiac vagal afferent neurotransmission in health and disease: review and knowledge gaps Frontiers in Neuroscience autonomic vagus afferent cardiovascular disease parasympathetic myocardial infarction |
| title | Cardiac vagal afferent neurotransmission in health and disease: review and knowledge gaps |
| title_full | Cardiac vagal afferent neurotransmission in health and disease: review and knowledge gaps |
| title_fullStr | Cardiac vagal afferent neurotransmission in health and disease: review and knowledge gaps |
| title_full_unstemmed | Cardiac vagal afferent neurotransmission in health and disease: review and knowledge gaps |
| title_short | Cardiac vagal afferent neurotransmission in health and disease: review and knowledge gaps |
| title_sort | cardiac vagal afferent neurotransmission in health and disease review and knowledge gaps |
| topic | autonomic vagus afferent cardiovascular disease parasympathetic myocardial infarction |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1192188/full |
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