An fMRI study of visuo-vestibular interactions following vestibular neuritis
Vestibular neuritis (VN) is characterised by acute vertigo due to a sudden loss of unilateral vestibular function. A considerable proportion of VN patients proceed to develop chronic symptoms of dizziness, including visually induced dizziness, specifically during head turns. Here we investigated whe...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218303188 |
| _version_ | 1828858659650666496 |
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| author | R.E. Roberts H. Ahmad M. Patel Danai Dima R. Ibitoye M. Sharif R. Leech Q. Arshad A.M. Bronstein |
| author_facet | R.E. Roberts H. Ahmad M. Patel Danai Dima R. Ibitoye M. Sharif R. Leech Q. Arshad A.M. Bronstein |
| author_sort | R.E. Roberts |
| collection | DOAJ |
| description | Vestibular neuritis (VN) is characterised by acute vertigo due to a sudden loss of unilateral vestibular function. A considerable proportion of VN patients proceed to develop chronic symptoms of dizziness, including visually induced dizziness, specifically during head turns. Here we investigated whether the development of such poor clinical outcomes following VN, is associated with abnormal visuo-vestibular cortical processing. Accordingly, we applied functional magnetic resonance imaging to assess brain responses of chronic VN patients and compared these to controls during both congruent (co-directional) and incongruent (opposite directions) visuo-vestibular stimulation (i.e. emulating situations that provoke symptoms in patients). We observed a focal significant difference in BOLD signal in the primary visual cortex V1 between patients and controls in the congruent condition (small volume corrected level of p < .05 FWE). Importantly, this reduced BOLD signal in V1 was negatively correlated with functional status measured with validated clinical questionnaires. Our findings suggest that central compensation and in turn clinical outcomes in VN are partly mediated by adaptive mechanisms associated with the early visual cortex. Keywords: fMRI, Visual-cortex, Oscillopsia, Vertigo, Vestibular compensation, Vestibular neuritis |
| first_indexed | 2024-12-13T02:01:05Z |
| format | Article |
| id | doaj.art-5fea5a8a98e44ff1aef1a4f237f10731 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-13T02:01:05Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-5fea5a8a98e44ff1aef1a4f237f107312022-12-22T00:03:15ZengElsevierNeuroImage: Clinical2213-15822018-01-012010101017An fMRI study of visuo-vestibular interactions following vestibular neuritisR.E. Roberts0H. Ahmad1M. Patel2Danai Dima3R. Ibitoye4M. Sharif5R. Leech6Q. Arshad7A.M. Bronstein8Neuro-otology Unit, Division of Brain Sciences, Charing Cross Hospital, Imperial College London, London W6 8RP, UKNeuro-otology Unit, Division of Brain Sciences, Charing Cross Hospital, Imperial College London, London W6 8RP, UKNeuro-otology Unit, Division of Brain Sciences, Charing Cross Hospital, Imperial College London, London W6 8RP, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, Camberwell, London SE5 8AF, UK; Department of Psychology, School of Arts and Social Sciences, City, University of London, London, UKNeuro-otology Unit, Division of Brain Sciences, Charing Cross Hospital, Imperial College London, London W6 8RP, UKNeuro-otology Unit, Division of Brain Sciences, Charing Cross Hospital, Imperial College London, London W6 8RP, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, Camberwell, London SE5 8AF, UK; De Crespigny Park, Camberwell, London SE5 8AF, UK; Computational, Cognitive and Clinical Neuroimaging Laboratory, Division of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UKNeuro-otology Unit, Division of Brain Sciences, Charing Cross Hospital, Imperial College London, London W6 8RP, UKNeuro-otology Unit, Division of Brain Sciences, Charing Cross Hospital, Imperial College London, London W6 8RP, UK; Corresponding author at: Neuro-otology Unit, Division of Brain Sciences, Charing Cross Hospital Campus, Imperial College, Fulham Palace Road, London W6 8RF, UK.Vestibular neuritis (VN) is characterised by acute vertigo due to a sudden loss of unilateral vestibular function. A considerable proportion of VN patients proceed to develop chronic symptoms of dizziness, including visually induced dizziness, specifically during head turns. Here we investigated whether the development of such poor clinical outcomes following VN, is associated with abnormal visuo-vestibular cortical processing. Accordingly, we applied functional magnetic resonance imaging to assess brain responses of chronic VN patients and compared these to controls during both congruent (co-directional) and incongruent (opposite directions) visuo-vestibular stimulation (i.e. emulating situations that provoke symptoms in patients). We observed a focal significant difference in BOLD signal in the primary visual cortex V1 between patients and controls in the congruent condition (small volume corrected level of p < .05 FWE). Importantly, this reduced BOLD signal in V1 was negatively correlated with functional status measured with validated clinical questionnaires. Our findings suggest that central compensation and in turn clinical outcomes in VN are partly mediated by adaptive mechanisms associated with the early visual cortex. Keywords: fMRI, Visual-cortex, Oscillopsia, Vertigo, Vestibular compensation, Vestibular neuritishttp://www.sciencedirect.com/science/article/pii/S2213158218303188 |
| spellingShingle | R.E. Roberts H. Ahmad M. Patel Danai Dima R. Ibitoye M. Sharif R. Leech Q. Arshad A.M. Bronstein An fMRI study of visuo-vestibular interactions following vestibular neuritis NeuroImage: Clinical |
| title | An fMRI study of visuo-vestibular interactions following vestibular neuritis |
| title_full | An fMRI study of visuo-vestibular interactions following vestibular neuritis |
| title_fullStr | An fMRI study of visuo-vestibular interactions following vestibular neuritis |
| title_full_unstemmed | An fMRI study of visuo-vestibular interactions following vestibular neuritis |
| title_short | An fMRI study of visuo-vestibular interactions following vestibular neuritis |
| title_sort | fmri study of visuo vestibular interactions following vestibular neuritis |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218303188 |
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