Prevalence of Occult HBV Infection in Dialysis Patients Referred to Sari Dialysis Center
Background and purpose: One of the possible factors for the continuation of hepatitis B infection in hemodialysis adults is the presence of hidden hepatitis B. Considering the risk of occult hepatitis B infection in people with immunodeficiency disorders, especially hemodialysis patients, the aim of...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-10-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-19190-en.pdf |
| _version_ | 1827698554456506368 |
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| author | Lotfollah Davood Hossein Jalali Roya Poormojib Mohammad Abedi Samakoosh Tahoora Mousavi |
| author_facet | Lotfollah Davood Hossein Jalali Roya Poormojib Mohammad Abedi Samakoosh Tahoora Mousavi |
| author_sort | Lotfollah Davood |
| collection | DOAJ |
| description | Background and purpose: One of the possible factors for the continuation of hepatitis B infection in hemodialysis adults is the presence of hidden hepatitis B. Considering the risk of occult hepatitis B infection in people with immunodeficiency disorders, especially hemodialysis patients, the aim of this study was to investigate the frequency of occult hepatitis B among dialysis patients in Sari.
Materials and methods: This cross-sectional descriptive research was conducted in Sari, 2018. Blood samples were taken from dialysis patients before dialysis. Then, HBV serology tests (HBs-Ab, HBs-Ag, HBV PCR, and HBc-Ab) were performed using ELISA method. Data analysis was done using SPSS V20. Chi-square test was used to find correlation between qualitative variables. Also, the differences were compared using independent t-test, and P<0.05 was considered significant.
Results: A total of 279 dialysis patients were investigated in this study. The chi-square test showed that there was no significant difference between the two groups in terms of gender (P>0.05), but significantly, the majority of the studied patients had a previous history of diabetes and high blood pressure (P<0.05). The findings revealed that there was no significant relationship between latent hepatitis B and demographic information (P>0.05). Independent t-test showed that the average age of people with latent hepatitis B was significantly higher than the rest of dialysis patients. (P=0.030). Of the patients, nine (3.23%) had positive HBs-Ag, of whom seven were under treatment and two did not need any treatment. Despite two complete series of vaccination against hepatitis B, six patients (2%) with negative HBs-Ag and HBs-Ab were reported to have positive HBc-Ab. Two cases of them (0.71%) were PCR positive, which were real latent hepatitis, and four others were recorded as old recovered hepatitis.
Conclusion: The findings suggested that HBs-Ag was a necessary but not sufficient factor in patients with End-Stage Renal Disease (ESRD); therefore, it was recommended to evaluate HBc-Ab and to test PCR for positive cases. |
| first_indexed | 2024-03-10T13:32:53Z |
| format | Article |
| id | doaj.art-5feafd80f1ca45f2970c747dd4f2d1d3 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-10T13:32:53Z |
| publishDate | 2023-10-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-5feafd80f1ca45f2970c747dd4f2d1d32023-11-21T07:44:49ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-10-0133225155161Prevalence of Occult HBV Infection in Dialysis Patients Referred to Sari Dialysis CenterLotfollah Davood0Hossein Jalali1Roya Poormojib2Mohammad Abedi Samakoosh3Tahoora Mousavi4 Associate Professor, Department of Infectious Diseases, Antimicrobial Resistance Research Center, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran Medical Student, Antimicrobial Resistance Research Center, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Department of Internal Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: One of the possible factors for the continuation of hepatitis B infection in hemodialysis adults is the presence of hidden hepatitis B. Considering the risk of occult hepatitis B infection in people with immunodeficiency disorders, especially hemodialysis patients, the aim of this study was to investigate the frequency of occult hepatitis B among dialysis patients in Sari. Materials and methods: This cross-sectional descriptive research was conducted in Sari, 2018. Blood samples were taken from dialysis patients before dialysis. Then, HBV serology tests (HBs-Ab, HBs-Ag, HBV PCR, and HBc-Ab) were performed using ELISA method. Data analysis was done using SPSS V20. Chi-square test was used to find correlation between qualitative variables. Also, the differences were compared using independent t-test, and P<0.05 was considered significant. Results: A total of 279 dialysis patients were investigated in this study. The chi-square test showed that there was no significant difference between the two groups in terms of gender (P>0.05), but significantly, the majority of the studied patients had a previous history of diabetes and high blood pressure (P<0.05). The findings revealed that there was no significant relationship between latent hepatitis B and demographic information (P>0.05). Independent t-test showed that the average age of people with latent hepatitis B was significantly higher than the rest of dialysis patients. (P=0.030). Of the patients, nine (3.23%) had positive HBs-Ag, of whom seven were under treatment and two did not need any treatment. Despite two complete series of vaccination against hepatitis B, six patients (2%) with negative HBs-Ag and HBs-Ab were reported to have positive HBc-Ab. Two cases of them (0.71%) were PCR positive, which were real latent hepatitis, and four others were recorded as old recovered hepatitis. Conclusion: The findings suggested that HBs-Ag was a necessary but not sufficient factor in patients with End-Stage Renal Disease (ESRD); therefore, it was recommended to evaluate HBc-Ab and to test PCR for positive cases.http://jmums.mazums.ac.ir/article-1-19190-en.pdfdialysisoccult hepatitisliver fibrosisimmunodeficiency |
| spellingShingle | Lotfollah Davood Hossein Jalali Roya Poormojib Mohammad Abedi Samakoosh Tahoora Mousavi Prevalence of Occult HBV Infection in Dialysis Patients Referred to Sari Dialysis Center Journal of Mazandaran University of Medical Sciences dialysis occult hepatitis liver fibrosis immunodeficiency |
| title | Prevalence of Occult HBV Infection in Dialysis Patients Referred to Sari Dialysis Center |
| title_full | Prevalence of Occult HBV Infection in Dialysis Patients Referred to Sari Dialysis Center |
| title_fullStr | Prevalence of Occult HBV Infection in Dialysis Patients Referred to Sari Dialysis Center |
| title_full_unstemmed | Prevalence of Occult HBV Infection in Dialysis Patients Referred to Sari Dialysis Center |
| title_short | Prevalence of Occult HBV Infection in Dialysis Patients Referred to Sari Dialysis Center |
| title_sort | prevalence of occult hbv infection in dialysis patients referred to sari dialysis center |
| topic | dialysis occult hepatitis liver fibrosis immunodeficiency |
| url | http://jmums.mazums.ac.ir/article-1-19190-en.pdf |
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