MPEG1/Perforin-2 Haploinsufficiency Associated Polymicrobial Skin Infections and Considerations for Interferon-γ Therapy

MPEG1/Perforin-2 Haploinsufficiency Associated Polymicrobial Skin Infections and Considerations for Interferon-γ Therapy

IntroductionMacrophage expressed gene 1 (MPEG1) is highly expressed in macrophages and other phagocytes. The gene encodes a bactericidal pore-forming protein, dubbed Perforin-2. Structural-, animal-, and cell-based studies have established that perforin-2 facilitates the destruction of phagocytosed...

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Bibliographic Details
Main Authors: Leidy C. Merselis, Shirley Y. Jiang, Stanley F. Nelson, Hane Lee, Kavitha K. Prabaker, Jennifer L. Baker, George P. Munson, Manish J. Butte
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
MPEG1 p.Tyr430*
perforin-2
primary immunodeficiency
membrane attack complex
interferon gamma
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.601584/full

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