Evolution of ribosomal protein network architectures
Abstract To perform an accurate protein synthesis, ribosomes accomplish complex tasks involving the long-range communication between its functional centres such as the peptidyl transfer centre, the tRNA bindings sites and the peptide exit tunnel. How information is transmitted between these sites re...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-80194-4 |
| _version_ | 1818733819885256704 |
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| author | Youri Timsit Grégoire Sergeant-Perthuis Daniel Bennequin |
| author_facet | Youri Timsit Grégoire Sergeant-Perthuis Daniel Bennequin |
| author_sort | Youri Timsit |
| collection | DOAJ |
| description | Abstract To perform an accurate protein synthesis, ribosomes accomplish complex tasks involving the long-range communication between its functional centres such as the peptidyl transfer centre, the tRNA bindings sites and the peptide exit tunnel. How information is transmitted between these sites remains one of the major challenges in current ribosome research. Many experimental studies have revealed that some r-proteins play essential roles in remote communication and the possible involvement of r-protein networks in these processes have been recently proposed. Our phylogenetic, structural and mathematical study reveals that of the three kingdom’s r-protein networks converged towards non-random graphs where r-proteins collectively coevolved to optimize interconnection between functional centres. The massive acquisition of conserved aromatic residues at the interfaces and along the extensions of the newly connected eukaryotic r-proteins also highlights that a strong selective pressure acts on their sequences probably for the formation of new allosteric pathways in the network. |
| first_indexed | 2024-12-17T23:55:32Z |
| format | Article |
| id | doaj.art-5fee6d0af3124cb590bbc7b9a586495c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T23:55:32Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5fee6d0af3124cb590bbc7b9a586495c2022-12-21T21:28:05ZengNature PortfolioScientific Reports2045-23222021-01-0111111310.1038/s41598-020-80194-4Evolution of ribosomal protein network architecturesYouri Timsit0Grégoire Sergeant-Perthuis1Daniel Bennequin2Mediterranean Institute of Oceanography UM 110, Aix-Marseille Université, CNRS, IRDInstitut de Mathématiques de Jussieu - Paris Rive Gauche (IMJ-PRG), UMR 7586, CNRS, Université Paris DiderotInstitut de Mathématiques de Jussieu - Paris Rive Gauche (IMJ-PRG), UMR 7586, CNRS, Université Paris DiderotAbstract To perform an accurate protein synthesis, ribosomes accomplish complex tasks involving the long-range communication between its functional centres such as the peptidyl transfer centre, the tRNA bindings sites and the peptide exit tunnel. How information is transmitted between these sites remains one of the major challenges in current ribosome research. Many experimental studies have revealed that some r-proteins play essential roles in remote communication and the possible involvement of r-protein networks in these processes have been recently proposed. Our phylogenetic, structural and mathematical study reveals that of the three kingdom’s r-protein networks converged towards non-random graphs where r-proteins collectively coevolved to optimize interconnection between functional centres. The massive acquisition of conserved aromatic residues at the interfaces and along the extensions of the newly connected eukaryotic r-proteins also highlights that a strong selective pressure acts on their sequences probably for the formation of new allosteric pathways in the network.https://doi.org/10.1038/s41598-020-80194-4 |
| spellingShingle | Youri Timsit Grégoire Sergeant-Perthuis Daniel Bennequin Evolution of ribosomal protein network architectures Scientific Reports |
| title | Evolution of ribosomal protein network architectures |
| title_full | Evolution of ribosomal protein network architectures |
| title_fullStr | Evolution of ribosomal protein network architectures |
| title_full_unstemmed | Evolution of ribosomal protein network architectures |
| title_short | Evolution of ribosomal protein network architectures |
| title_sort | evolution of ribosomal protein network architectures |
| url | https://doi.org/10.1038/s41598-020-80194-4 |
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