Post COVID-19 vaccination Guillain-Barre syndrome: three cases

Guillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy. In two-thirds of patients, it is preceded by an upper respiratory or gastrointestinal tract infection. Temporally associated cases of GBS following COVID-19 vaccination have been described with different COVID-19 vaccines...

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Main Authors: Seyedehnarges Tabatabaee, Fatemeh Rezania, Sayed Mohammed Jawad Alwedaie, Ensieh Malekdar, Zahra Badi, Seyed Mohammad Tabatabaei, Zahra Mirzaasgari
Format: Article
Language:English
Published: Taylor & Francis Group 2022-11-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Online Access:http://dx.doi.org/10.1080/21645515.2022.2045153
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author Seyedehnarges Tabatabaee
Fatemeh Rezania
Sayed Mohammed Jawad Alwedaie
Ensieh Malekdar
Zahra Badi
Seyed Mohammad Tabatabaei
Zahra Mirzaasgari
author_facet Seyedehnarges Tabatabaee
Fatemeh Rezania
Sayed Mohammed Jawad Alwedaie
Ensieh Malekdar
Zahra Badi
Seyed Mohammad Tabatabaei
Zahra Mirzaasgari
author_sort Seyedehnarges Tabatabaee
collection DOAJ
description Guillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy. In two-thirds of patients, it is preceded by an upper respiratory or gastrointestinal tract infection. Temporally associated cases of GBS following COVID-19 vaccination have been described with different COVID-19 vaccines. In this study, we report three cases of GBS patients following COVID-19 vaccine. Two of the studied patients received the Sinopharm vaccine and one patient received the AstraZeneca vaccine. All patients were diagnosed with acute motor axonal neuropathy (AMAN) type of GBS, on nerve conduction studies. All three patients responded well to treatment with intravenous immunoglobulin (IVIg). The association between COVID-19 vaccination and GBS is not well understood and more studies are needed to establish whether it is merely an association or a causal relationship.
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spelling doaj.art-5fef01a3e576443dab22fa3c2cb19e202023-09-26T13:19:05ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2022-11-0118510.1080/21645515.2022.20451532045153Post COVID-19 vaccination Guillain-Barre syndrome: three casesSeyedehnarges Tabatabaee0Fatemeh Rezania1Sayed Mohammed Jawad Alwedaie2Ensieh Malekdar3Zahra Badi4Seyed Mohammad Tabatabaei5Zahra Mirzaasgari6Iran university of medical sciencesSt Vincents HospitalMedical university of BahrainMotamedi HospitalErfan HospitalUniversity of TehranIran university of medical sciencesGuillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy. In two-thirds of patients, it is preceded by an upper respiratory or gastrointestinal tract infection. Temporally associated cases of GBS following COVID-19 vaccination have been described with different COVID-19 vaccines. In this study, we report three cases of GBS patients following COVID-19 vaccine. Two of the studied patients received the Sinopharm vaccine and one patient received the AstraZeneca vaccine. All patients were diagnosed with acute motor axonal neuropathy (AMAN) type of GBS, on nerve conduction studies. All three patients responded well to treatment with intravenous immunoglobulin (IVIg). The association between COVID-19 vaccination and GBS is not well understood and more studies are needed to establish whether it is merely an association or a causal relationship.http://dx.doi.org/10.1080/21645515.2022.2045153coronavirus 2019vaccineguillain-barre syndromeastrazenecasinopharm
spellingShingle Seyedehnarges Tabatabaee
Fatemeh Rezania
Sayed Mohammed Jawad Alwedaie
Ensieh Malekdar
Zahra Badi
Seyed Mohammad Tabatabaei
Zahra Mirzaasgari
Post COVID-19 vaccination Guillain-Barre syndrome: three cases
Human Vaccines & Immunotherapeutics
coronavirus 2019
vaccine
guillain-barre syndrome
astrazeneca
sinopharm
title Post COVID-19 vaccination Guillain-Barre syndrome: three cases
title_full Post COVID-19 vaccination Guillain-Barre syndrome: three cases
title_fullStr Post COVID-19 vaccination Guillain-Barre syndrome: three cases
title_full_unstemmed Post COVID-19 vaccination Guillain-Barre syndrome: three cases
title_short Post COVID-19 vaccination Guillain-Barre syndrome: three cases
title_sort post covid 19 vaccination guillain barre syndrome three cases
topic coronavirus 2019
vaccine
guillain-barre syndrome
astrazeneca
sinopharm
url http://dx.doi.org/10.1080/21645515.2022.2045153
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