Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy
Background Chronic plantar ulcers in leprosy (CPUL) occur in areas that have a sensory and an autonomic nerve impairment where the wound healing takes longer. Framycetin gauze dressing (FGD) is best used in the wound healing process during the inflammatory phase because it contains antibiotics. Epig...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-11-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | http://dx.doi.org/10.1080/09546634.2020.1729333 |
| _version_ | 1797683609285427200 |
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| author | C. R. S. Prakoeswa R. N. Oktaviyanti D. M. Indramaya E. Hendradri S. Sawitri L. Astari D. Damayanti M. Y. Listiawan |
| author_facet | C. R. S. Prakoeswa R. N. Oktaviyanti D. M. Indramaya E. Hendradri S. Sawitri L. Astari D. Damayanti M. Y. Listiawan |
| author_sort | C. R. S. Prakoeswa |
| collection | DOAJ |
| description | Background Chronic plantar ulcers in leprosy (CPUL) occur in areas that have a sensory and an autonomic nerve impairment where the wound healing takes longer. Framycetin gauze dressing (FGD) is best used in the wound healing process during the inflammatory phase because it contains antibiotics. Epigallocatechin gallate (EGCG) is the highest component in the extract of green tea that can accelerate blood vessel formation, has an anti-inflammatory effect, and reepithelialization. Objective To investigate the effect of topical EGCG 1% on the healing of CPUL. Materials and methods An analytical experimental approach comparing the topical EGCG 1% and FGD applied every 3 days up to 8 weeks on the healing of CPUL. Size of the ulcers, side effects and possible complications from both approaches were monitored weekly. Results Ulcer healing in the EGCG group was significantly better than the FGD group with significant clinical and statistical differences (p < .032). There were no side effects in both the study groups. Complications, such as an increase in the size of the ulcer, were noted in one subject in the control group. This may have been caused by FGD and claw foot condition. Conclusions EGCG 1% is more effective than FGD in accelerating the healing process of CPUL. |
| first_indexed | 2024-03-12T00:16:58Z |
| format | Article |
| id | doaj.art-5fefe7a4fc9044f5a2dc525cc1bc2546 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:16:58Z |
| publishDate | 2021-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-5fefe7a4fc9044f5a2dc525cc1bc25462023-09-15T14:23:05ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532021-11-013281026103010.1080/09546634.2020.17293331729333Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosyC. R. S. Prakoeswa0R. N. Oktaviyanti1D. M. Indramaya2E. Hendradri3S. Sawitri4L. Astari5D. Damayanti6M. Y. Listiawan7Faculty of Medicine,Department of Dermatology and Venereology, Universitas Airlangga – Dr Soetomo General Academic HospitalFaculty of Medicine,Department of Dermatology and Venereology, Universitas Airlangga – Dr Soetomo General Academic HospitalFaculty of Medicine,Department of Dermatology and Venereology, Universitas Airlangga – Dr Soetomo General Academic HospitalFaculty of Pharmacy, Department of Pharmaceutics, Universitas AirlanggaFaculty of Medicine,Department of Dermatology and Venereology, Universitas Airlangga – Dr Soetomo General Academic HospitalFaculty of Medicine,Department of Dermatology and Venereology, Universitas Airlangga – Dr Soetomo General Academic HospitalFaculty of Medicine,Department of Dermatology and Venereology, Universitas Airlangga – Dr Soetomo General Academic HospitalFaculty of Medicine,Department of Dermatology and Venereology, Universitas Airlangga – Dr Soetomo General Academic HospitalBackground Chronic plantar ulcers in leprosy (CPUL) occur in areas that have a sensory and an autonomic nerve impairment where the wound healing takes longer. Framycetin gauze dressing (FGD) is best used in the wound healing process during the inflammatory phase because it contains antibiotics. Epigallocatechin gallate (EGCG) is the highest component in the extract of green tea that can accelerate blood vessel formation, has an anti-inflammatory effect, and reepithelialization. Objective To investigate the effect of topical EGCG 1% on the healing of CPUL. Materials and methods An analytical experimental approach comparing the topical EGCG 1% and FGD applied every 3 days up to 8 weeks on the healing of CPUL. Size of the ulcers, side effects and possible complications from both approaches were monitored weekly. Results Ulcer healing in the EGCG group was significantly better than the FGD group with significant clinical and statistical differences (p < .032). There were no side effects in both the study groups. Complications, such as an increase in the size of the ulcer, were noted in one subject in the control group. This may have been caused by FGD and claw foot condition. Conclusions EGCG 1% is more effective than FGD in accelerating the healing process of CPUL.http://dx.doi.org/10.1080/09546634.2020.1729333epigallocatechin gallate (egcg)chronic plantar ulcers in leprosy (cpul)framycetin gauze dressing (fgd) |
| spellingShingle | C. R. S. Prakoeswa R. N. Oktaviyanti D. M. Indramaya E. Hendradri S. Sawitri L. Astari D. Damayanti M. Y. Listiawan Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy Journal of Dermatological Treatment epigallocatechin gallate (egcg) chronic plantar ulcers in leprosy (cpul) framycetin gauze dressing (fgd) |
| title | Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy |
| title_full | Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy |
| title_fullStr | Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy |
| title_full_unstemmed | Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy |
| title_short | Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy |
| title_sort | efficacy of topical epigallocatechin gallate egcg 1 on the healing of chronic plantar ulcers in leprosy |
| topic | epigallocatechin gallate (egcg) chronic plantar ulcers in leprosy (cpul) framycetin gauze dressing (fgd) |
| url | http://dx.doi.org/10.1080/09546634.2020.1729333 |
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