Dosimetric Comparative Study between Single and Dual Isocenter Stereotactic Body Radiotherapy Plans in Treatment of Multiple Lesions Non-Small Cell Lung Cancer Patients
Introduction: stereotactic body radiotherapy (SBRT) is the most proper treatment for multi lesions non-small cell lung cancer (NSCLC) for enhanced good coverage and minimizing dose to organs at risk (OARs). This study aims to compare single and dual isocenter SBRT plans and discuss which technique w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-05-01
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| Series: | Iranian Journal of Medical Physics |
| Subjects: | |
| Online Access: | https://ijmp.mums.ac.ir/article_20355_20a2e0294cc5f3839fc03757cd4ea427.pdf |
| _version_ | 1797209622852927488 |
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| author | Mona Ibraheim Magda Hanafy Khaled El-Shahat Mohammed Bayomy Hany Attallah Nesma khalil |
| author_facet | Mona Ibraheim Magda Hanafy Khaled El-Shahat Mohammed Bayomy Hany Attallah Nesma khalil |
| author_sort | Mona Ibraheim |
| collection | DOAJ |
| description | Introduction: stereotactic body radiotherapy (SBRT) is the most proper treatment for multi lesions non-small cell lung cancer (NSCLC) for enhanced good coverage and minimizing dose to organs at risk (OARs). This study aims to compare single and dual isocenter SBRT plans and discuss which technique we can use in multi lesions NSCLC.
Material and Methods: Ten patients with multi targets NSCLC underwent two different SBRT treatment planning techniques including single isocenter and dual isocenter. We quantitatively assessed plans qualities by dose-volume metrics. Conformity index (CI), Confirmation Number (CN), heterogeneity index (HI), gradient distance (GD), Gradient index (GI), and maximum percentage dose at 2cm all around PTV ( ) were gathered, tallied, and statistically examined. OARs were evaluated and the dose to the normal lung was evaluated using V5, V10, V20, and mean lung dose (MLD).
Results: There is an insignificant difference between single and dual isocenter plans in CI, CN, HI, GD, GI, and dose spillage where the mean distance between two lesions was 5.50 ± 1.50 cm, and the mean total volume of the planning target volume (PTV) was 42.60±21.33cc. For single and dual isocenter plans, the median MLD was 4.5(2-16)Gy and 4 (2-16)Gy respectively (p=0.25).
Conclusion: Plan quality of single isocenter was equal to dual isocenter for SBRT treatment of multi lung lesions with maximum distances between them was 10 cm. Dual isocenter took time during setup and matching for cone beam computed tomography (CBCT). |
| first_indexed | 2024-04-24T09:57:38Z |
| format | Article |
| id | doaj.art-5ff01603fe29403a97922e987ccb07a5 |
| institution | Directory Open Access Journal |
| issn | 2345-3672 |
| language | English |
| last_indexed | 2024-04-24T09:57:38Z |
| publishDate | 2023-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Physics |
| spelling | doaj.art-5ff01603fe29403a97922e987ccb07a52024-04-14T06:28:22ZengMashhad University of Medical SciencesIranian Journal of Medical Physics2345-36722023-05-0120314615210.22038/ijmp.2022.57836.206420355Dosimetric Comparative Study between Single and Dual Isocenter Stereotactic Body Radiotherapy Plans in Treatment of Multiple Lesions Non-Small Cell Lung Cancer PatientsMona Ibraheim0Magda Hanafy1Khaled El-Shahat2Mohammed Bayomy3Hany Attallah4Nesma khalil5Physics Department, Faculty of Science, Zagazig University, Zagazig, Egypt.Physics Department, Faculty of Science, Zagazig University, Zagazig, Egypt.Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, El-Azhar University, Cairo, EgyptClinical Oncology and Nuclear Medicine Department, Faculty of Medicine, ZagazigUniversity, Zagazig, Egypt.Radiation Oncology Department, International Medical Center (IMC), Egypt.Clinical Oncology and Nuclear Medicine department, Zagazig University Hospitals, Egypt.Introduction: stereotactic body radiotherapy (SBRT) is the most proper treatment for multi lesions non-small cell lung cancer (NSCLC) for enhanced good coverage and minimizing dose to organs at risk (OARs). This study aims to compare single and dual isocenter SBRT plans and discuss which technique we can use in multi lesions NSCLC. Material and Methods: Ten patients with multi targets NSCLC underwent two different SBRT treatment planning techniques including single isocenter and dual isocenter. We quantitatively assessed plans qualities by dose-volume metrics. Conformity index (CI), Confirmation Number (CN), heterogeneity index (HI), gradient distance (GD), Gradient index (GI), and maximum percentage dose at 2cm all around PTV ( ) were gathered, tallied, and statistically examined. OARs were evaluated and the dose to the normal lung was evaluated using V5, V10, V20, and mean lung dose (MLD). Results: There is an insignificant difference between single and dual isocenter plans in CI, CN, HI, GD, GI, and dose spillage where the mean distance between two lesions was 5.50 ± 1.50 cm, and the mean total volume of the planning target volume (PTV) was 42.60±21.33cc. For single and dual isocenter plans, the median MLD was 4.5(2-16)Gy and 4 (2-16)Gy respectively (p=0.25). Conclusion: Plan quality of single isocenter was equal to dual isocenter for SBRT treatment of multi lung lesions with maximum distances between them was 10 cm. Dual isocenter took time during setup and matching for cone beam computed tomography (CBCT).https://ijmp.mums.ac.ir/article_20355_20a2e0294cc5f3839fc03757cd4ea427.pdfstereotactic body radiotherapyvmatlung cancer |
| spellingShingle | Mona Ibraheim Magda Hanafy Khaled El-Shahat Mohammed Bayomy Hany Attallah Nesma khalil Dosimetric Comparative Study between Single and Dual Isocenter Stereotactic Body Radiotherapy Plans in Treatment of Multiple Lesions Non-Small Cell Lung Cancer Patients Iranian Journal of Medical Physics stereotactic body radiotherapy vmat lung cancer |
| title | Dosimetric Comparative Study between Single and Dual Isocenter Stereotactic Body Radiotherapy Plans in Treatment of Multiple Lesions Non-Small Cell Lung Cancer Patients |
| title_full | Dosimetric Comparative Study between Single and Dual Isocenter Stereotactic Body Radiotherapy Plans in Treatment of Multiple Lesions Non-Small Cell Lung Cancer Patients |
| title_fullStr | Dosimetric Comparative Study between Single and Dual Isocenter Stereotactic Body Radiotherapy Plans in Treatment of Multiple Lesions Non-Small Cell Lung Cancer Patients |
| title_full_unstemmed | Dosimetric Comparative Study between Single and Dual Isocenter Stereotactic Body Radiotherapy Plans in Treatment of Multiple Lesions Non-Small Cell Lung Cancer Patients |
| title_short | Dosimetric Comparative Study between Single and Dual Isocenter Stereotactic Body Radiotherapy Plans in Treatment of Multiple Lesions Non-Small Cell Lung Cancer Patients |
| title_sort | dosimetric comparative study between single and dual isocenter stereotactic body radiotherapy plans in treatment of multiple lesions non small cell lung cancer patients |
| topic | stereotactic body radiotherapy vmat lung cancer |
| url | https://ijmp.mums.ac.ir/article_20355_20a2e0294cc5f3839fc03757cd4ea427.pdf |
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