Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes
Bone regeneration has gained attention in the biomedical field, which has led to the development of materials and synthesis methods meant to improve osseointegration and cellular bone activity. The properties of hydroxyapatite, a type of calcium phosphate, have been researched to determine its advan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/16/3/1303 |
| _version_ | 1797623904263471104 |
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| author | Ana Zastulka Simona Clichici Maria Tomoaia-Cotisel Aurora Mocanu Cecilia Roman Cristian-Doru Olteanu Bogdan Culic Teodora Mocan |
| author_facet | Ana Zastulka Simona Clichici Maria Tomoaia-Cotisel Aurora Mocanu Cecilia Roman Cristian-Doru Olteanu Bogdan Culic Teodora Mocan |
| author_sort | Ana Zastulka |
| collection | DOAJ |
| description | Bone regeneration has gained attention in the biomedical field, which has led to the development of materials and synthesis methods meant to improve osseointegration and cellular bone activity. The properties of hydroxyapatite, a type of calcium phosphate, have been researched to determine its advantages for bone tissue engineering, particularly its biocompatibility and ability to interact with bone cells. Recently, the advantages of utilizing nanomolecules of hydroxyapatite, combined with various substances, in order to enhance and combine their characteristics, have been reported in the literature. This review will outline the cellular and molecular roles of hydroxypatite, its interactions with bone cells, and its nano-combinations with various ions and natural products and their effects on bone growth, development, and bone repair. |
| first_indexed | 2024-03-11T09:35:29Z |
| format | Article |
| id | doaj.art-5ff07ec1a24e40f4b4fc09c06a9c6d94 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-11T09:35:29Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-5ff07ec1a24e40f4b4fc09c06a9c6d942023-11-16T17:20:03ZengMDPI AGMaterials1996-19442023-02-01163130310.3390/ma16031303Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative PurposesAna Zastulka0Simona Clichici1Maria Tomoaia-Cotisel2Aurora Mocanu3Cecilia Roman4Cristian-Doru Olteanu5Bogdan Culic6Teodora Mocan7Physiology Department, Iuliu Hatieganu University of Medicine and Pharmacy, 1 Clinicilor Street, 400006 Cluj-Napoca, RomaniaPhysiology Department, Iuliu Hatieganu University of Medicine and Pharmacy, 1 Clinicilor Street, 400006 Cluj-Napoca, RomaniaDepartment of Chemical Engineering, Faculty of Chemistry and Chemical Engineering, Research Center in Physical Chemistry, Babes-Bolyai University of Cluj-Napoca, 11 Arany Janos Str., 400028 Cluj-Napoca, RomaniaDepartment of Chemical Engineering, Faculty of Chemistry and Chemical Engineering, Research Center in Physical Chemistry, Babes-Bolyai University of Cluj-Napoca, 11 Arany Janos Str., 400028 Cluj-Napoca, RomaniaINCDO-INOE 2000, Research Institute for Analytical Instrumentation, 400296 Cluj-Napoca, RomaniaOrthodontic Department, Iuliu Hatieganu University of Medicine and Pharmacy, 31 Avram Iancu Street, 400083 Cluj-Napoca, RomaniaDepartment of Prosthetic Dentistry and Dental Materials, Iuliu Hatieganu University of Medicine and Pharmacy, 32 Clinicilor Street, 400012 Cluj-Napoca, RomaniaPhysiology Department, Iuliu Hatieganu University of Medicine and Pharmacy, 1 Clinicilor Street, 400006 Cluj-Napoca, RomaniaBone regeneration has gained attention in the biomedical field, which has led to the development of materials and synthesis methods meant to improve osseointegration and cellular bone activity. The properties of hydroxyapatite, a type of calcium phosphate, have been researched to determine its advantages for bone tissue engineering, particularly its biocompatibility and ability to interact with bone cells. Recently, the advantages of utilizing nanomolecules of hydroxyapatite, combined with various substances, in order to enhance and combine their characteristics, have been reported in the literature. This review will outline the cellular and molecular roles of hydroxypatite, its interactions with bone cells, and its nano-combinations with various ions and natural products and their effects on bone growth, development, and bone repair.https://www.mdpi.com/1996-1944/16/3/1303hydroxyapatitebone cellssignalingsynthesis methodsnanoparticlescurcumin |
| spellingShingle | Ana Zastulka Simona Clichici Maria Tomoaia-Cotisel Aurora Mocanu Cecilia Roman Cristian-Doru Olteanu Bogdan Culic Teodora Mocan Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes Materials hydroxyapatite bone cells signaling synthesis methods nanoparticles curcumin |
| title | Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes |
| title_full | Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes |
| title_fullStr | Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes |
| title_full_unstemmed | Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes |
| title_short | Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes |
| title_sort | recent trends in hydroxyapatite supplementation for osteoregenerative purposes |
| topic | hydroxyapatite bone cells signaling synthesis methods nanoparticles curcumin |
| url | https://www.mdpi.com/1996-1944/16/3/1303 |
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