Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

Airway cholinergic nerves play a key role in airway physiology and disease. In asthma and other diseases of the respiratory tract, airway cholinergic neurons undergo plasticity and contribute to airway hyperresponsiveness and mucus secretion. We currently lack human in vitro models for airway cholin...

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Bibliographic Details
Main Authors: P. A. Goldsteen, A. M. Sabogal Guaqueta, P. P. M. F. A. Mulder, I. S. T. Bos, M. Eggens, L. Van der Koog, J. T. Soeiro, A. J. Halayko, K. Mathwig, L. E. M. Kistemaker, E. M. J. Verpoorte, A. M. Dolga, R. Gosens
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
neuron
asthma
organ-on-chip
cholinergic
stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.991072/full

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