Age at onset in multiple sclerosis as a possible predictor for cognitive impairment in children and adolescents
Pediatric-onset multiple sclerosis (MS) can lead to cognitive impairment (CI). In general, in early-onset MS, there are disturbances in cognitive processes, such as information processing speed, attention, and controlling functions. Also, unlike adults with MS, children show a failure in various sph...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2020-08-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
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| Online Access: | https://nnp.ima-press.net/nnp/article/view/1395 |
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| author | M. D. Bogdanova T. T. Batysheva Yu. V. Mikadze R. Ts. Bembeeva E. Yu. Volkova |
| author_facet | M. D. Bogdanova T. T. Batysheva Yu. V. Mikadze R. Ts. Bembeeva E. Yu. Volkova |
| author_sort | M. D. Bogdanova |
| collection | DOAJ |
| description | Pediatric-onset multiple sclerosis (MS) can lead to cognitive impairment (CI). In general, in early-onset MS, there are disturbances in cognitive processes, such as information processing speed, attention, and controlling functions. Also, unlike adults with MS, children show a failure in various spheres of speech activity. The age of onset in MS, its duration and recurrence rate can affect not only the accumulation of a stable neurological deficit, but also the state of the cognitive sphere.Objective: to study of the features of CI in children and adolescents with MS; to assess the relationship of CI to clinical characteristics, such as age at onset in the disease and its duration.Patients and methods. The study involved 45 pediatric and adolescent patients with an established diagnosis of MS, who underwent a general neuropsychological examination of the cognitive sphere (Luria’s tests) with transfer to a point system; in addition, psychometric techniques were used to assess attention, controlling functions, memory, verbal fluency, and various types of thinking. Clinical characteristics, such as age at onset in MS and its duration at the time of the examination, were also taken into account.Results and discussion. The leading factors that combine certain symptom complexes of CI in children and adolescents with MS were established. These factors include attention, controlling functions, auditory-verbal and visuospatial memories, various spheres of speech activity. Early-onset MS (at age of 5–8 years) was ascertained to have a greater impact on the formation of speech and controlling functions than adolescence- onset (at age of 13–16-years).Conclusion. The risk of cognitive deficit and subsequent disability was found to be highest in early-onset MS. |
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| format | Article |
| id | doaj.art-5ff2aa559f514c81b579af3da10b4c82 |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2025-02-18T20:02:19Z |
| publishDate | 2020-08-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-5ff2aa559f514c81b579af3da10b4c822024-10-17T16:15:27ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422020-08-01121S91410.14412/2074-2711-2020-1S-9-141012Age at onset in multiple sclerosis as a possible predictor for cognitive impairment in children and adolescentsM. D. Bogdanova0T. T. Batysheva1Yu. V. Mikadze2R. Ts. Bembeeva3E. Yu. Volkova4I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaResearch and Practical Center of Pediatric Psychoneurology, Moscow Healthcare DepartmentM.V. Lomonosov Moscow State University; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center for the Brain and Neurotechnologies, Federal Medical Biological Agency of RussiaN.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Russian Children’s Clinical Hospital, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Children’s Clinical Hospital, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaPediatric-onset multiple sclerosis (MS) can lead to cognitive impairment (CI). In general, in early-onset MS, there are disturbances in cognitive processes, such as information processing speed, attention, and controlling functions. Also, unlike adults with MS, children show a failure in various spheres of speech activity. The age of onset in MS, its duration and recurrence rate can affect not only the accumulation of a stable neurological deficit, but also the state of the cognitive sphere.Objective: to study of the features of CI in children and adolescents with MS; to assess the relationship of CI to clinical characteristics, such as age at onset in the disease and its duration.Patients and methods. The study involved 45 pediatric and adolescent patients with an established diagnosis of MS, who underwent a general neuropsychological examination of the cognitive sphere (Luria’s tests) with transfer to a point system; in addition, psychometric techniques were used to assess attention, controlling functions, memory, verbal fluency, and various types of thinking. Clinical characteristics, such as age at onset in MS and its duration at the time of the examination, were also taken into account.Results and discussion. The leading factors that combine certain symptom complexes of CI in children and adolescents with MS were established. These factors include attention, controlling functions, auditory-verbal and visuospatial memories, various spheres of speech activity. Early-onset MS (at age of 5–8 years) was ascertained to have a greater impact on the formation of speech and controlling functions than adolescence- onset (at age of 13–16-years).Conclusion. The risk of cognitive deficit and subsequent disability was found to be highest in early-onset MS.https://nnp.ima-press.net/nnp/article/view/1395multiple sclerosispediatric multiple sclerosismultiple sclerosis in childrencognitive impairmentneuropsychological diagnosisage at onset |
| spellingShingle | M. D. Bogdanova T. T. Batysheva Yu. V. Mikadze R. Ts. Bembeeva E. Yu. Volkova Age at onset in multiple sclerosis as a possible predictor for cognitive impairment in children and adolescents Неврология, нейропсихиатрия, психосоматика multiple sclerosis pediatric multiple sclerosis multiple sclerosis in children cognitive impairment neuropsychological diagnosis age at onset |
| title | Age at onset in multiple sclerosis as a possible predictor for cognitive impairment in children and adolescents |
| title_full | Age at onset in multiple sclerosis as a possible predictor for cognitive impairment in children and adolescents |
| title_fullStr | Age at onset in multiple sclerosis as a possible predictor for cognitive impairment in children and adolescents |
| title_full_unstemmed | Age at onset in multiple sclerosis as a possible predictor for cognitive impairment in children and adolescents |
| title_short | Age at onset in multiple sclerosis as a possible predictor for cognitive impairment in children and adolescents |
| title_sort | age at onset in multiple sclerosis as a possible predictor for cognitive impairment in children and adolescents |
| topic | multiple sclerosis pediatric multiple sclerosis multiple sclerosis in children cognitive impairment neuropsychological diagnosis age at onset |
| url | https://nnp.ima-press.net/nnp/article/view/1395 |
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