Does Endometrial Compaction Predict Clinical Pregnancy Rate after Cleavage Stage Frozen Embryo Transfer?
Objectives: This study aimed to determine the relationships between endometrial compaction and pregnancy outcome in patients receiving artificial endometrial preparation for frozen embryo transfer (FET) cycles. Materials and Methods: This prospective cohort study was performed in a university-affili...
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| Format: | Article |
| Language: | English |
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Aras Part Medical International Press
2023-07-01
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| Series: | Crescent Journal of Medical and Biological Sciences |
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| Online Access: | http://www.cjmb.org/pdf.php?id=583 |
| _version_ | 1797739547312783360 |
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| author | Mina Naghi Jafarabadi Maedeh Ahmadi Dastjerdi Batool Hossein Rashidi Mamak Shariat Fedyeh Haghollahi |
| author_facet | Mina Naghi Jafarabadi Maedeh Ahmadi Dastjerdi Batool Hossein Rashidi Mamak Shariat Fedyeh Haghollahi |
| author_sort | Mina Naghi Jafarabadi |
| collection | DOAJ |
| description | Objectives: This study aimed to determine the relationships between endometrial compaction and pregnancy outcome in patients receiving artificial endometrial preparation for frozen embryo transfer (FET) cycles. Materials and Methods: This prospective cohort study was performed in a university-affiliated fertility clinic from March 2020 to March 2021. The eligible women undergoing their first or second FET cycle and having the top grading cleavage stage embryos were enrolled. All patients received the same endometrial preparation regime. The alteration in endometrial thickness (EMT) between the day of progesterone initiation and the day of embryo transfer (ET) was measured using consecutive transvaginal sonography. The patients were divided into three groups based on the percentage of endometrial compaction (i.e., the difference of EMT at end of the estrogen-only phase and after three days of progesterone administration (ET day) divided by the EMT on the terminal day of the estrogen-only exposure). Results: Overall, 300 eligible women were evaluated and only 27.3% (82/300) of the studied cycles showed ≥5% compaction, whereas 72.6% (218/300) either expanded or showed minimal compaction. The clinical and ongoing pregnancy rates in group 2 (any expansion) were significantly higher than those in groups 1 and 3 (P=0.002 and P=0.01, respectively). Multivariable logistic regression test indicated that the cycles with any expansion in ET were independently associated with 3.1 times improvement in clinical pregnancy rate in comparison to those with any compaction (P=0.002). Conclusion: Gross endometrial compaction occurred in one-third of FET cycles with no significant positive effect on pregnancy outcomes after cleavage-stage ET. |
| first_indexed | 2024-03-12T13:59:45Z |
| format | Article |
| id | doaj.art-5ff7a47431d84564b0e8eb4c8fe9a598 |
| institution | Directory Open Access Journal |
| issn | 2148-9696 |
| language | English |
| last_indexed | 2024-03-12T13:59:45Z |
| publishDate | 2023-07-01 |
| publisher | Aras Part Medical International Press |
| record_format | Article |
| series | Crescent Journal of Medical and Biological Sciences |
| spelling | doaj.art-5ff7a47431d84564b0e8eb4c8fe9a5982023-08-22T08:18:44ZengAras Part Medical International PressCrescent Journal of Medical and Biological Sciences2148-96962023-07-0110313213610.34172/cjmb.2023.22CJMB-10080Does Endometrial Compaction Predict Clinical Pregnancy Rate after Cleavage Stage Frozen Embryo Transfer?Mina Naghi Jafarabadi0Maedeh Ahmadi Dastjerdi1Batool Hossein Rashidi2Mamak Shariat3Fedyeh Haghollahi4Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.Maternal, Fetal & Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.Objectives: This study aimed to determine the relationships between endometrial compaction and pregnancy outcome in patients receiving artificial endometrial preparation for frozen embryo transfer (FET) cycles. Materials and Methods: This prospective cohort study was performed in a university-affiliated fertility clinic from March 2020 to March 2021. The eligible women undergoing their first or second FET cycle and having the top grading cleavage stage embryos were enrolled. All patients received the same endometrial preparation regime. The alteration in endometrial thickness (EMT) between the day of progesterone initiation and the day of embryo transfer (ET) was measured using consecutive transvaginal sonography. The patients were divided into three groups based on the percentage of endometrial compaction (i.e., the difference of EMT at end of the estrogen-only phase and after three days of progesterone administration (ET day) divided by the EMT on the terminal day of the estrogen-only exposure). Results: Overall, 300 eligible women were evaluated and only 27.3% (82/300) of the studied cycles showed ≥5% compaction, whereas 72.6% (218/300) either expanded or showed minimal compaction. The clinical and ongoing pregnancy rates in group 2 (any expansion) were significantly higher than those in groups 1 and 3 (P=0.002 and P=0.01, respectively). Multivariable logistic regression test indicated that the cycles with any expansion in ET were independently associated with 3.1 times improvement in clinical pregnancy rate in comparison to those with any compaction (P=0.002). Conclusion: Gross endometrial compaction occurred in one-third of FET cycles with no significant positive effect on pregnancy outcomes after cleavage-stage ET.http://www.cjmb.org/pdf.php?id=583endometrium/diagnostic imagingfrozen-warmed embryo transferpregnancy outcome |
| spellingShingle | Mina Naghi Jafarabadi Maedeh Ahmadi Dastjerdi Batool Hossein Rashidi Mamak Shariat Fedyeh Haghollahi Does Endometrial Compaction Predict Clinical Pregnancy Rate after Cleavage Stage Frozen Embryo Transfer? Crescent Journal of Medical and Biological Sciences endometrium/diagnostic imaging frozen-warmed embryo transfer pregnancy outcome |
| title | Does Endometrial Compaction Predict Clinical Pregnancy Rate after Cleavage Stage Frozen Embryo Transfer? |
| title_full | Does Endometrial Compaction Predict Clinical Pregnancy Rate after Cleavage Stage Frozen Embryo Transfer? |
| title_fullStr | Does Endometrial Compaction Predict Clinical Pregnancy Rate after Cleavage Stage Frozen Embryo Transfer? |
| title_full_unstemmed | Does Endometrial Compaction Predict Clinical Pregnancy Rate after Cleavage Stage Frozen Embryo Transfer? |
| title_short | Does Endometrial Compaction Predict Clinical Pregnancy Rate after Cleavage Stage Frozen Embryo Transfer? |
| title_sort | does endometrial compaction predict clinical pregnancy rate after cleavage stage frozen embryo transfer |
| topic | endometrium/diagnostic imaging frozen-warmed embryo transfer pregnancy outcome |
| url | http://www.cjmb.org/pdf.php?id=583 |
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