Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients
The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 pathophysiology, and guide clinical decisions. This study aimed at assessing...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/9/4794 |
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| author | Judith Marín-Corral Jose Rodríguez-Morató Alex Gomez-Gomez Sergi Pascual-Guardia Rosana Muñoz-Bermúdez Anna Salazar-Degracia Purificación Pérez-Terán Marcos I. Restrepo Olha Khymenets Noemí Haro Joan Ramon Masclans Oscar J. Pozo |
| author_facet | Judith Marín-Corral Jose Rodríguez-Morató Alex Gomez-Gomez Sergi Pascual-Guardia Rosana Muñoz-Bermúdez Anna Salazar-Degracia Purificación Pérez-Terán Marcos I. Restrepo Olha Khymenets Noemí Haro Joan Ramon Masclans Oscar J. Pozo |
| author_sort | Judith Marín-Corral |
| collection | DOAJ |
| description | The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 pathophysiology, and guide clinical decisions. This study aimed at assessing the critical metabolic pathways altered with disease severity in hospitalized COVID-19 patients. Forty-nine hospitalized patients with COVID-19 pneumonia were enrolled in a prospective, observational, single-center study in Barcelona, Spain. Demographic, clinical, and analytical data at admission were registered. Plasma samples were collected within the first 48 h following hospitalization. Patients were stratified based on the severity of their evolution as moderate (N = 13), severe (N = 10), or critical (N = 26). A panel of 221 biomarkers was measured by targeted metabolomics in order to evaluate metabolic changes associated with subsequent disease severity. Our results show that obesity, respiratory rate, blood pressure, and oxygen saturation, as well as some analytical parameters and radiological findings, were all associated with disease severity. Additionally, ceramide metabolism, tryptophan degradation, and reductions in several metabolic reactions involving nicotinamide adenine nucleotide (NAD) at inclusion were significantly associated with respiratory severity and correlated with inflammation. In summary, assessment of the metabolomic profile of COVID-19 patients could assist in disease severity stratification and even in guiding clinical decisions. |
| first_indexed | 2024-03-10T11:47:11Z |
| format | Article |
| id | doaj.art-5ff7f55e0c194dbb9dd1c9bedb2b3cc0 |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:47:11Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5ff7f55e0c194dbb9dd1c9bedb2b3cc02023-11-21T18:00:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01229479410.3390/ijms22094794Metabolic Signatures Associated with Severity in Hospitalized COVID-19 PatientsJudith Marín-Corral0Jose Rodríguez-Morató1Alex Gomez-Gomez2Sergi Pascual-Guardia3Rosana Muñoz-Bermúdez4Anna Salazar-Degracia5Purificación Pérez-Terán6Marcos I. Restrepo7Olha Khymenets8Noemí Haro9Joan Ramon Masclans10Oscar J. Pozo11Critical Care Department, Hospital del Mar, 08003 Barcelona, SpainIntegrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, 08003 Barcelona, SpainIntegrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, 08003 Barcelona, SpainDivision of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USACritical Care Department, Hospital del Mar, 08003 Barcelona, SpainCritical Care Department, Hospital del Mar, 08003 Barcelona, SpainCritical Care Department, Hospital del Mar, 08003 Barcelona, SpainDivision of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USAIntegrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, 08003 Barcelona, SpainIntegrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, 08003 Barcelona, SpainCritical Care Department, Hospital del Mar, 08003 Barcelona, SpainIntegrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, 08003 Barcelona, SpainThe clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 pathophysiology, and guide clinical decisions. This study aimed at assessing the critical metabolic pathways altered with disease severity in hospitalized COVID-19 patients. Forty-nine hospitalized patients with COVID-19 pneumonia were enrolled in a prospective, observational, single-center study in Barcelona, Spain. Demographic, clinical, and analytical data at admission were registered. Plasma samples were collected within the first 48 h following hospitalization. Patients were stratified based on the severity of their evolution as moderate (N = 13), severe (N = 10), or critical (N = 26). A panel of 221 biomarkers was measured by targeted metabolomics in order to evaluate metabolic changes associated with subsequent disease severity. Our results show that obesity, respiratory rate, blood pressure, and oxygen saturation, as well as some analytical parameters and radiological findings, were all associated with disease severity. Additionally, ceramide metabolism, tryptophan degradation, and reductions in several metabolic reactions involving nicotinamide adenine nucleotide (NAD) at inclusion were significantly associated with respiratory severity and correlated with inflammation. In summary, assessment of the metabolomic profile of COVID-19 patients could assist in disease severity stratification and even in guiding clinical decisions.https://www.mdpi.com/1422-0067/22/9/4794COVID-19metabolomicsseveritykynurenineceramides |
| spellingShingle | Judith Marín-Corral Jose Rodríguez-Morató Alex Gomez-Gomez Sergi Pascual-Guardia Rosana Muñoz-Bermúdez Anna Salazar-Degracia Purificación Pérez-Terán Marcos I. Restrepo Olha Khymenets Noemí Haro Joan Ramon Masclans Oscar J. Pozo Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients International Journal of Molecular Sciences COVID-19 metabolomics severity kynurenine ceramides |
| title | Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients |
| title_full | Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients |
| title_fullStr | Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients |
| title_full_unstemmed | Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients |
| title_short | Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients |
| title_sort | metabolic signatures associated with severity in hospitalized covid 19 patients |
| topic | COVID-19 metabolomics severity kynurenine ceramides |
| url | https://www.mdpi.com/1422-0067/22/9/4794 |
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