System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular Diseases
Abstract: Cardiovascular diseases (CVDs) are leading causes of death in the world, owing to noticeable incidence and mortality. Traditional Chinese Medicine (TCM) SINI Decoction (SND) is used to prevent and treat CVDs, which has attracted extensive attention for its moderate and little side effects....
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500804&lng=en&tlng=en |
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| author | ZHIMING SHU TIANTIAN WU MOHAMED SHAHEN ZIHU GUO JIA SHU HE WANG AKHTAR H. SHAR MAYADA R. FARAG MAHMOUD ALAGAWANY MOHAMED E. ABD EL-HACK CHAOBIN LIU |
| author_facet | ZHIMING SHU TIANTIAN WU MOHAMED SHAHEN ZIHU GUO JIA SHU HE WANG AKHTAR H. SHAR MAYADA R. FARAG MAHMOUD ALAGAWANY MOHAMED E. ABD EL-HACK CHAOBIN LIU |
| author_sort | ZHIMING SHU |
| collection | DOAJ |
| description | Abstract: Cardiovascular diseases (CVDs) are leading causes of death in the world, owing to noticeable incidence and mortality. Traditional Chinese Medicine (TCM) SINI Decoction (SND) is used to prevent and treat CVDs, which has attracted extensive attention for its moderate and little side effects. However, the involved molecular mechanisms are exceedingly complicated and remain unclear. Systems pharmacology, as a novel approach that integrates systems biology and pharmacology plays a significant role in investigating the molecular mechanism of TCM. In systems pharmacology approach, we use to systematically uncover the mechanisms of action in Chinese medicinal formula SND as an effective treatment for CVDs, which mainly includes:1) molecular database building; 2) ADME evaluation; 3) target-fishing 4) network construction and analysis. The results show that 78 underlying valid ingredients and their corresponding 71 direct targets of SND were obtained. And SND take part in cardiomyocyte protection, blood pressure regulation, and lipid regulation module in treatment of CVDs by cooperative way. Systems pharmacology as an emerging field that investigates the molecular mechanisms of TCM through pharmacokinetic evaluation target prediction, and pathway analysis, which will facilitate the development of traditional Chinese herbs in modern medicine. |
| first_indexed | 2024-12-10T22:48:34Z |
| format | Article |
| id | doaj.art-5ffc87f44cea4aacba1468f1e72b0f55 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-10T22:48:34Z |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-5ffc87f44cea4aacba1468f1e72b0f552022-12-22T01:30:30ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-269091310.1590/0001-3765201920180424S0001-37652019000500804System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular DiseasesZHIMING SHUTIANTIAN WUMOHAMED SHAHENZIHU GUOJIA SHUHE WANGAKHTAR H. SHARMAYADA R. FARAGMAHMOUD ALAGAWANYMOHAMED E. ABD EL-HACKCHAOBIN LIUAbstract: Cardiovascular diseases (CVDs) are leading causes of death in the world, owing to noticeable incidence and mortality. Traditional Chinese Medicine (TCM) SINI Decoction (SND) is used to prevent and treat CVDs, which has attracted extensive attention for its moderate and little side effects. However, the involved molecular mechanisms are exceedingly complicated and remain unclear. Systems pharmacology, as a novel approach that integrates systems biology and pharmacology plays a significant role in investigating the molecular mechanism of TCM. In systems pharmacology approach, we use to systematically uncover the mechanisms of action in Chinese medicinal formula SND as an effective treatment for CVDs, which mainly includes:1) molecular database building; 2) ADME evaluation; 3) target-fishing 4) network construction and analysis. The results show that 78 underlying valid ingredients and their corresponding 71 direct targets of SND were obtained. And SND take part in cardiomyocyte protection, blood pressure regulation, and lipid regulation module in treatment of CVDs by cooperative way. Systems pharmacology as an emerging field that investigates the molecular mechanisms of TCM through pharmacokinetic evaluation target prediction, and pathway analysis, which will facilitate the development of traditional Chinese herbs in modern medicine.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500804&lng=en&tlng=ensystems pharmacologySINI DecoctionCardiovascular Diseasesmolecular mechanismstraditional Chinese herbs |
| spellingShingle | ZHIMING SHU TIANTIAN WU MOHAMED SHAHEN ZIHU GUO JIA SHU HE WANG AKHTAR H. SHAR MAYADA R. FARAG MAHMOUD ALAGAWANY MOHAMED E. ABD EL-HACK CHAOBIN LIU System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular Diseases Anais da Academia Brasileira de Ciências systems pharmacology SINI Decoction Cardiovascular Diseases molecular mechanisms traditional Chinese herbs |
| title | System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular Diseases |
| title_full | System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular Diseases |
| title_fullStr | System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular Diseases |
| title_full_unstemmed | System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular Diseases |
| title_short | System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular Diseases |
| title_sort | system pharmacology dissection of traditional chinese herbs sini decoction for treatment of cardiovascular diseases |
| topic | systems pharmacology SINI Decoction Cardiovascular Diseases molecular mechanisms traditional Chinese herbs |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500804&lng=en&tlng=en |
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