MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production.

MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production.

MicroRNAs have been shown to contribute to a repertoire of host-pathogen interactions during viral infection. Our previous study demonstrated that microRNA-30e* (miR-30e*) directly targeted the IκBα 3'-UTR and disrupted the NF-κB/IκBα negative feedback loop, leading to hyperactivation of NF-κB....

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Main Authors: Xun Zhu, Zhenjian He, Yiwen Hu, Weitao Wen, Cuiji Lin, Jianchen Yu, Jing Pan, Ran Li, Haijing Deng, Shaowei Liao, Jie Yuan, Jueheng Wu, Jun Li, Mengfeng Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4133224?pdf=render

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