Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house d...
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MDPI AG
2018-04-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/10/4/146 |
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| author | Dasom Shin Won Choi Hyunsu Bae |
| author_facet | Dasom Shin Won Choi Hyunsu Bae |
| author_sort | Dasom Shin |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE and DNCB. In contrast, these effects were abrogated in CD206 mannose receptor-deficient mice exposed to DFE and DNCB in the ear. These data suggest that bvPLA2 alleviates atopic skin inflammation via interaction with CD206. |
| first_indexed | 2024-04-11T22:04:08Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T22:04:08Z |
| publishDate | 2018-04-01 |
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| series | Toxins |
| spelling | doaj.art-5ffec42210d6489a844bffcb910d91e32022-12-22T04:00:48ZengMDPI AGToxins2072-66512018-04-0110414610.3390/toxins10040146toxins10040146Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose ReceptorDasom Shin0Won Choi1Hyunsu Bae2Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 kyungheedae-ro, dongdaemoon-ku, Seoul 02447, KoreaDepartment of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 kyungheedae-ro, dongdaemoon-ku, Seoul 02447, KoreaDepartment of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 kyungheedae-ro, dongdaemoon-ku, Seoul 02447, KoreaAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE and DNCB. In contrast, these effects were abrogated in CD206 mannose receptor-deficient mice exposed to DFE and DNCB in the ear. These data suggest that bvPLA2 alleviates atopic skin inflammation via interaction with CD206.http://www.mdpi.com/2072-6651/10/4/146atopic dermatitis (AD)house dust mite extract (DFE)2,4-dinitrochlorobenzene (DNCB)bee venom phospholipase A2 (bvPLA2)skin inflammationCD206mannose receptor |
| spellingShingle | Dasom Shin Won Choi Hyunsu Bae Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor Toxins atopic dermatitis (AD) house dust mite extract (DFE) 2,4-dinitrochlorobenzene (DNCB) bee venom phospholipase A2 (bvPLA2) skin inflammation CD206 mannose receptor |
| title | Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor |
| title_full | Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor |
| title_fullStr | Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor |
| title_full_unstemmed | Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor |
| title_short | Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor |
| title_sort | bee venom phospholipase a2 alleviate house dust mite induced atopic dermatitis like skin lesions by the cd206 mannose receptor |
| topic | atopic dermatitis (AD) house dust mite extract (DFE) 2,4-dinitrochlorobenzene (DNCB) bee venom phospholipase A2 (bvPLA2) skin inflammation CD206 mannose receptor |
| url | http://www.mdpi.com/2072-6651/10/4/146 |
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