Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study
<p>Abstract</p> <p>Background</p> <p>Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-01-01
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| Series: | Respiratory Research |
| Online Access: | http://respiratory-research.com/content/12/1/16 |
| _version_ | 1828465758215077888 |
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| author | Antic Tjana Sarvà Maria Bertino Gaetano Caponnetto Pasquale Russo Cristina Polosa Riccardo Mancuso Stefania Al-Delaimy Wael K |
| author_facet | Antic Tjana Sarvà Maria Bertino Gaetano Caponnetto Pasquale Russo Cristina Polosa Riccardo Mancuso Stefania Al-Delaimy Wael K |
| author_sort | Antic Tjana |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma.</p> <p>Methods</p> <p>Allergic rhinitis subjects with no asthma (n = 371) were followed-up for 10 years and routinely examined for asthma diagnosis. In those who developed asthma (n = 152), clinical severity and levels of asthma control were determined. Among these subjects, 74 (48.7%) were current smokers, 17 (11.2%) former smokers, and 61 (40.1%) never smokers.</p> <p>Results</p> <p>When comparing current or past smokers to never smokers they had a higher risk of severe asthma in the univariate analysis, which became non-significant in the multivariate analysis. On the other hand, the categories of pack-years were significantly related to severe asthma in a dose response relationship in both the univariate and multivariate analysis: compared to 0 pack years, those who smoked 1-10 pack-years had an OR(95% CI) of 1.47(0.46-4.68), those who smoked 11-20 pack-years had an OR of 2.85(1.09-7.46) and those who smoked more than 20 pack-years had an OR of 5.59(1.44-21.67) to develop more severe asthma. Smokers with asthma were also more likely to have uncontrolled disease. A significant dose-response relationship was observed for pack-years and uncontrolled asthma. Compared to 0 pack years, those who smoked 1-10 pack-years had an OR of 5.51(1.73-17.54) and those who smoked more than 10 pack-years had an OR of 13.38(4.57-39.19) to have uncontrolled asthma.</p> <p>Conclusions</p> <p>The current findings support the hypothesis that cigarette smoking is an important predictor of asthma severity and poor asthma control.</p> |
| first_indexed | 2024-12-11T03:37:47Z |
| format | Article |
| id | doaj.art-5ffedcfef891432e8264df5fa17dfa9d |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-11T03:37:47Z |
| publishDate | 2011-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-5ffedcfef891432e8264df5fa17dfa9d2022-12-22T01:22:12ZengBMCRespiratory Research1465-99212011-01-011211610.1186/1465-9921-12-16Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal studyAntic TjanaSarvà MariaBertino GaetanoCaponnetto PasqualeRusso CristinaPolosa RiccardoMancuso StefaniaAl-Delaimy Wael K<p>Abstract</p> <p>Background</p> <p>Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma.</p> <p>Methods</p> <p>Allergic rhinitis subjects with no asthma (n = 371) were followed-up for 10 years and routinely examined for asthma diagnosis. In those who developed asthma (n = 152), clinical severity and levels of asthma control were determined. Among these subjects, 74 (48.7%) were current smokers, 17 (11.2%) former smokers, and 61 (40.1%) never smokers.</p> <p>Results</p> <p>When comparing current or past smokers to never smokers they had a higher risk of severe asthma in the univariate analysis, which became non-significant in the multivariate analysis. On the other hand, the categories of pack-years were significantly related to severe asthma in a dose response relationship in both the univariate and multivariate analysis: compared to 0 pack years, those who smoked 1-10 pack-years had an OR(95% CI) of 1.47(0.46-4.68), those who smoked 11-20 pack-years had an OR of 2.85(1.09-7.46) and those who smoked more than 20 pack-years had an OR of 5.59(1.44-21.67) to develop more severe asthma. Smokers with asthma were also more likely to have uncontrolled disease. A significant dose-response relationship was observed for pack-years and uncontrolled asthma. Compared to 0 pack years, those who smoked 1-10 pack-years had an OR of 5.51(1.73-17.54) and those who smoked more than 10 pack-years had an OR of 13.38(4.57-39.19) to have uncontrolled asthma.</p> <p>Conclusions</p> <p>The current findings support the hypothesis that cigarette smoking is an important predictor of asthma severity and poor asthma control.</p>http://respiratory-research.com/content/12/1/16 |
| spellingShingle | Antic Tjana Sarvà Maria Bertino Gaetano Caponnetto Pasquale Russo Cristina Polosa Riccardo Mancuso Stefania Al-Delaimy Wael K Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study Respiratory Research |
| title | Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study |
| title_full | Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study |
| title_fullStr | Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study |
| title_full_unstemmed | Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study |
| title_short | Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study |
| title_sort | greater severity of new onset asthma in allergic subjects who smoke a 10 year longitudinal study |
| url | http://respiratory-research.com/content/12/1/16 |
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