Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease
The gut epithelium not only provides a physical barrier to separate a noxious outside from a sterile inside but also allows for highly regulated interactions between bacteria and their products, and components of the immune system. Homeostatic maintenance of an intact epithelial barrier is paramount...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.944982/full |
| _version_ | 1818023058278973440 |
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| author | Sonia Ghilas Ryan O’Keefe Lisa Anna Mielke Dinesh Raghu Michael Buchert Matthias Ernst |
| author_facet | Sonia Ghilas Ryan O’Keefe Lisa Anna Mielke Dinesh Raghu Michael Buchert Matthias Ernst |
| author_sort | Sonia Ghilas |
| collection | DOAJ |
| description | The gut epithelium not only provides a physical barrier to separate a noxious outside from a sterile inside but also allows for highly regulated interactions between bacteria and their products, and components of the immune system. Homeostatic maintenance of an intact epithelial barrier is paramount to health, requiring an intricately regulated and highly adaptive response of various cells of the immune system. Prolonged homeostatic imbalance can result in chronic inflammation, tumorigenesis and inefficient antitumor immune control. Here we provide an update on the role of innate lymphoid cells, macrophages and dendritic cells, which collectively play a critical role in epithelial barrier maintenance and provide an important linkage between the classical innate and adaptive arm of the immune system. These interactions modify the capacity of the gut epithelium to undergo continuous renewal, safeguard against tumor formation and provide feedback to the gut microbiome, which acts as a seminal contributor to cellular homeostasis of the gut. |
| first_indexed | 2024-12-10T03:38:17Z |
| format | Article |
| id | doaj.art-6001a4cb60d94a2ab87c1558bf8667d2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T03:38:17Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6001a4cb60d94a2ab87c1558bf8667d22022-12-22T02:03:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.944982944982Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and diseaseSonia Ghilas0Ryan O’Keefe1Lisa Anna Mielke2Dinesh Raghu3Michael Buchert4Matthias Ernst5Mucosal Immunity Laboratory, Olivia Newton-John Cancer Research Institute, and La Trobe University - School of Cancer Medicine, Heidelberg, VIC, AustraliaCancer and Inflammation Program, Olivia Newton-John Cancer Research Institute, and La Trobe University - School of Cancer Medicine, Heidelberg, VIC, AustraliaMucosal Immunity Laboratory, Olivia Newton-John Cancer Research Institute, and La Trobe University - School of Cancer Medicine, Heidelberg, VIC, AustraliaMucosal Immunity Laboratory, Olivia Newton-John Cancer Research Institute, and La Trobe University - School of Cancer Medicine, Heidelberg, VIC, AustraliaCancer and Inflammation Program, Olivia Newton-John Cancer Research Institute, and La Trobe University - School of Cancer Medicine, Heidelberg, VIC, AustraliaCancer and Inflammation Program, Olivia Newton-John Cancer Research Institute, and La Trobe University - School of Cancer Medicine, Heidelberg, VIC, AustraliaThe gut epithelium not only provides a physical barrier to separate a noxious outside from a sterile inside but also allows for highly regulated interactions between bacteria and their products, and components of the immune system. Homeostatic maintenance of an intact epithelial barrier is paramount to health, requiring an intricately regulated and highly adaptive response of various cells of the immune system. Prolonged homeostatic imbalance can result in chronic inflammation, tumorigenesis and inefficient antitumor immune control. Here we provide an update on the role of innate lymphoid cells, macrophages and dendritic cells, which collectively play a critical role in epithelial barrier maintenance and provide an important linkage between the classical innate and adaptive arm of the immune system. These interactions modify the capacity of the gut epithelium to undergo continuous renewal, safeguard against tumor formation and provide feedback to the gut microbiome, which acts as a seminal contributor to cellular homeostasis of the gut.https://www.frontiersin.org/articles/10.3389/fimmu.2022.944982/fullintestinal epitheliummacrophages (MΦ)dendritic cells (DC)innate lymphoid cells (ILC)homeostasisinflammation |
| spellingShingle | Sonia Ghilas Ryan O’Keefe Lisa Anna Mielke Dinesh Raghu Michael Buchert Matthias Ernst Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease Frontiers in Immunology intestinal epithelium macrophages (MΦ) dendritic cells (DC) innate lymphoid cells (ILC) homeostasis inflammation |
| title | Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease |
| title_full | Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease |
| title_fullStr | Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease |
| title_full_unstemmed | Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease |
| title_short | Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease |
| title_sort | crosstalk between epithelium myeloid and innate lymphoid cells during gut homeostasis and disease |
| topic | intestinal epithelium macrophages (MΦ) dendritic cells (DC) innate lymphoid cells (ILC) homeostasis inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.944982/full |
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