Cancer in thyroid nodules with fine-needle aspiration in Korean pediatric populations
Purpose To determine the prevalence and clinical findings of benign thyroid nodules and cancer in Korean pediatric patients with thyroid nodules. Methods We investigated the medical records of 134 patients aged younger than 18 years who had a goiter, thyroid nodule, thyroid mass, or thyroid cancer w...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2018-06-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
| Subjects: | |
| Online Access: | http://e-apem.org/upload/pdf/apem-2018-23-2-94.pdf |
| _version_ | 1818031619775135744 |
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| author | Joon Ho Jang So Hyun Park Kyung soon Cho Won Kyung Cho Young Jin Suh Byung Kyu Suh Dae Kyun Koh |
| author_facet | Joon Ho Jang So Hyun Park Kyung soon Cho Won Kyung Cho Young Jin Suh Byung Kyu Suh Dae Kyun Koh |
| author_sort | Joon Ho Jang |
| collection | DOAJ |
| description | Purpose To determine the prevalence and clinical findings of benign thyroid nodules and cancer in Korean pediatric patients with thyroid nodules. Methods We investigated the medical records of 134 patients aged younger than 18 years who had a goiter, thyroid nodule, thyroid mass, or thyroid cancer who underwent fine needle aspiration biopsy (FNAB). Results The study population included 113 females (84.3%) and 21 males (13.7%); the mean patient age was 16.1±2.3 years (range, 8–18 years). Of the 134 patients, 24 (18.0%) were finally diagnosed with thyroid cancer, of which 20 (83.3%) were papillary cancer and 4 (16.7%) were follicular cancer. No patient was exposed to radiation. FNAB revealed malignant cancer in 21 of the patients; 3 were initially reported as having benign tumors by FNAB, but were later diagnosed with follicular cancer. An additional 13 patients were suspected to have malignant tumors by FNAB, with a final diagnosis of nodular hyperplasia. Cystic nodules were more common in the benign group. The percentages of cervical lymphadenopathy and irregular nodular margins were higher in the malignant group compared to the benign group. Cervical lymphadenopathy and FNAB malignant findings were highly suggestive of malignant nodules. Conclusions Thyroid cancer prevalence in a Korean pediatric population is comparable to reported estimates of worldwide thyroid cancer prevalence. In this population, cancer predominates on the right thyroid lobe. Papillary thyroid cancers are dominant in the Korean pediatric population but are less prevalent than in Korean adults. As expected, FNAB was highly accurate in predicting malignant nodules. |
| first_indexed | 2024-12-10T05:54:22Z |
| format | Article |
| id | doaj.art-600346dd03284765bfd60330f987a96f |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-12-10T05:54:22Z |
| publishDate | 2018-06-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-600346dd03284765bfd60330f987a96f2022-12-22T01:59:58ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922018-06-01232949810.6065/apem.2018.23.2.94729Cancer in thyroid nodules with fine-needle aspiration in Korean pediatric populationsJoon Ho Jang0So Hyun Park1Kyung soon Cho2Won Kyung Cho3Young Jin Suh4Byung Kyu Suh5Dae Kyun Koh6 Department of Pediatrics, St. Vincent’s Hospital, The Catholic University of Korea, Korea Central Children’s Hospital, Hwasung, Korea Department of Pediatrics, Bucheon St. Mary’s Hospital, The Catholic University of Korea, Bucheon, Korea Department of Pediatrics, St. Vincent’s Hospital, The Catholic University of Korea, Korea Department of Surgery, St. Vincent’s Hospital, The Catholic University of Korea, Suwon, Korea Department of Pediatrics, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Korea Department of Pediatrics, St. Vincent’s Hospital, The Catholic University of Korea, KoreaPurpose To determine the prevalence and clinical findings of benign thyroid nodules and cancer in Korean pediatric patients with thyroid nodules. Methods We investigated the medical records of 134 patients aged younger than 18 years who had a goiter, thyroid nodule, thyroid mass, or thyroid cancer who underwent fine needle aspiration biopsy (FNAB). Results The study population included 113 females (84.3%) and 21 males (13.7%); the mean patient age was 16.1±2.3 years (range, 8–18 years). Of the 134 patients, 24 (18.0%) were finally diagnosed with thyroid cancer, of which 20 (83.3%) were papillary cancer and 4 (16.7%) were follicular cancer. No patient was exposed to radiation. FNAB revealed malignant cancer in 21 of the patients; 3 were initially reported as having benign tumors by FNAB, but were later diagnosed with follicular cancer. An additional 13 patients were suspected to have malignant tumors by FNAB, with a final diagnosis of nodular hyperplasia. Cystic nodules were more common in the benign group. The percentages of cervical lymphadenopathy and irregular nodular margins were higher in the malignant group compared to the benign group. Cervical lymphadenopathy and FNAB malignant findings were highly suggestive of malignant nodules. Conclusions Thyroid cancer prevalence in a Korean pediatric population is comparable to reported estimates of worldwide thyroid cancer prevalence. In this population, cancer predominates on the right thyroid lobe. Papillary thyroid cancers are dominant in the Korean pediatric population but are less prevalent than in Korean adults. As expected, FNAB was highly accurate in predicting malignant nodules.http://e-apem.org/upload/pdf/apem-2018-23-2-94.pdfPediatricThyroid noduleThyroid cancer |
| spellingShingle | Joon Ho Jang So Hyun Park Kyung soon Cho Won Kyung Cho Young Jin Suh Byung Kyu Suh Dae Kyun Koh Cancer in thyroid nodules with fine-needle aspiration in Korean pediatric populations Annals of Pediatric Endocrinology & Metabolism Pediatric Thyroid nodule Thyroid cancer |
| title | Cancer in thyroid nodules with fine-needle aspiration in Korean pediatric populations |
| title_full | Cancer in thyroid nodules with fine-needle aspiration in Korean pediatric populations |
| title_fullStr | Cancer in thyroid nodules with fine-needle aspiration in Korean pediatric populations |
| title_full_unstemmed | Cancer in thyroid nodules with fine-needle aspiration in Korean pediatric populations |
| title_short | Cancer in thyroid nodules with fine-needle aspiration in Korean pediatric populations |
| title_sort | cancer in thyroid nodules with fine needle aspiration in korean pediatric populations |
| topic | Pediatric Thyroid nodule Thyroid cancer |
| url | http://e-apem.org/upload/pdf/apem-2018-23-2-94.pdf |
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