Evaluation of the Preventive Efficacy and Safety of Azoximer Bromide in Healthcare Workers in Contact with Patients Hospitalized for COVID-19
Relevance. Despite the implementation of measures to reduce morbidity and mortality among medical workers who are in contact with patients hospitalized for a new coronavirus infection caused by SARS-CoV-2 (hereinafter – COVID-19), their level remains high today. Given the difficulty of achieving the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2022-03-01
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| Series: | Эпидемиология и вакцинопрофилактика |
| Subjects: | |
| Online Access: | https://www.epidemvac.ru/jour/article/view/1463 |
| _version_ | 1826567400165736448 |
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| author | K V Kasyanenko O V Maltsev K V Kozlov K V Zhdanov A A Kuzin A E Zobov A V Puzikov |
| author_facet | K V Kasyanenko O V Maltsev K V Kozlov K V Zhdanov A A Kuzin A E Zobov A V Puzikov |
| author_sort | K V Kasyanenko |
| collection | DOAJ |
| description | Relevance. Despite the implementation of measures to reduce morbidity and mortality among medical workers who are in contact with patients hospitalized for a new coronavirus infection caused by SARS-CoV-2 (hereinafter – COVID-19), their level remains high today. Given the difficulty of achieving the required number of vaccinated to form collective immunity, the issue of finding additional drug-based ways to prevent COVID-19, especially in risk groups, becomes urgent. Aims. To evaluate the effect of azoximer bromide on the number of cases of confirmed COVID-19 disease among medical workers, as well as on the level of chronic fatigue in the study groups. Materials and methods: 78 men and women were included in the study. The experimental group consisted of 41 people who took azoximer bromide for 38 days. The comparison group consisted of 37 people who were not prescribed azoximer bromide. The epidemiological efficacy of the drug was evaluated. Statistical evaluation of the significance of the differences was carried out using the Student's t-test, Pearson's criterion χ2. Results. The number of study participants with COVID-19 in the experimental group was significantly lower than in the comparison group. A significantly faster reduction of manifestations of chronic fatigue syndrome was noted in study participants who took azoximer bromide. There were no adverse events during the administration of the studied drug by the study participants. Conclusions. Azoximer bromide has shown epidemiological efficacy when used by medical workers directly providing medical care to patients with COVID-19 (when working in the «red zone»), including contributing to the more rapid normalization of the psychological state of medical workers |
| first_indexed | 2024-04-10T02:48:47Z |
| format | Article |
| id | doaj.art-6005d1ffef81471bb9f38d63252d07c0 |
| institution | Directory Open Access Journal |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| last_indexed | 2025-03-14T11:06:56Z |
| publishDate | 2022-03-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj.art-6005d1ffef81471bb9f38d63252d07c02025-03-02T10:40:34ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942022-03-01211677310.31631/2073-3046-2022-21-1-67-73816Evaluation of the Preventive Efficacy and Safety of Azoximer Bromide in Healthcare Workers in Contact with Patients Hospitalized for COVID-19K V Kasyanenko0O V Maltsev1K V Kozlov2K V Zhdanov3A A Kuzin4A E Zobov5A V Puzikov6S. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyRelevance. Despite the implementation of measures to reduce morbidity and mortality among medical workers who are in contact with patients hospitalized for a new coronavirus infection caused by SARS-CoV-2 (hereinafter – COVID-19), their level remains high today. Given the difficulty of achieving the required number of vaccinated to form collective immunity, the issue of finding additional drug-based ways to prevent COVID-19, especially in risk groups, becomes urgent. Aims. To evaluate the effect of azoximer bromide on the number of cases of confirmed COVID-19 disease among medical workers, as well as on the level of chronic fatigue in the study groups. Materials and methods: 78 men and women were included in the study. The experimental group consisted of 41 people who took azoximer bromide for 38 days. The comparison group consisted of 37 people who were not prescribed azoximer bromide. The epidemiological efficacy of the drug was evaluated. Statistical evaluation of the significance of the differences was carried out using the Student's t-test, Pearson's criterion χ2. Results. The number of study participants with COVID-19 in the experimental group was significantly lower than in the comparison group. A significantly faster reduction of manifestations of chronic fatigue syndrome was noted in study participants who took azoximer bromide. There were no adverse events during the administration of the studied drug by the study participants. Conclusions. Azoximer bromide has shown epidemiological efficacy when used by medical workers directly providing medical care to patients with COVID-19 (when working in the «red zone»), including contributing to the more rapid normalization of the psychological state of medical workershttps://www.epidemvac.ru/jour/article/view/1463covid-19sars-cov-2prophylaxisazoximer bromidehealthcare workers no conflict of interest to declare |
| spellingShingle | K V Kasyanenko O V Maltsev K V Kozlov K V Zhdanov A A Kuzin A E Zobov A V Puzikov Evaluation of the Preventive Efficacy and Safety of Azoximer Bromide in Healthcare Workers in Contact with Patients Hospitalized for COVID-19 Эпидемиология и вакцинопрофилактика covid-19 sars-cov-2 prophylaxis azoximer bromide healthcare workers no conflict of interest to declare |
| title | Evaluation of the Preventive Efficacy and Safety of Azoximer Bromide in Healthcare Workers in Contact with Patients Hospitalized for COVID-19 |
| title_full | Evaluation of the Preventive Efficacy and Safety of Azoximer Bromide in Healthcare Workers in Contact with Patients Hospitalized for COVID-19 |
| title_fullStr | Evaluation of the Preventive Efficacy and Safety of Azoximer Bromide in Healthcare Workers in Contact with Patients Hospitalized for COVID-19 |
| title_full_unstemmed | Evaluation of the Preventive Efficacy and Safety of Azoximer Bromide in Healthcare Workers in Contact with Patients Hospitalized for COVID-19 |
| title_short | Evaluation of the Preventive Efficacy and Safety of Azoximer Bromide in Healthcare Workers in Contact with Patients Hospitalized for COVID-19 |
| title_sort | evaluation of the preventive efficacy and safety of azoximer bromide in healthcare workers in contact with patients hospitalized for covid 19 |
| topic | covid-19 sars-cov-2 prophylaxis azoximer bromide healthcare workers no conflict of interest to declare |
| url | https://www.epidemvac.ru/jour/article/view/1463 |
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