Relationship between interleukin ⁃ 6 ⁃ 572 gene polymorphism and aggressive periodontitis in Chinese
Objective To investigate the association between interleukin⁃6 ⁃572 gene polymorphism and aggressive periodontitis. Methods A case⁃control study involved 83 patients with aggressive periodontitis (AgP) and 69 health con⁃ trols was held, and the genotype and allele distributions of interleukin⁃6 ⁃5...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2017-11-01
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| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | http://www.kqjbfz.com/EN/10.12016/j.issn.2096-1456.2017.11.008 |
| Summary: | Objective To investigate the association between interleukin⁃6 ⁃572 gene polymorphism and aggressive
periodontitis. Methods A case⁃control study involved 83 patients with aggressive periodontitis (AgP) and 69 health con⁃
trols was held, and the genotype and allele distributions of interleukin⁃6 ⁃572 gene polymorphism were analyzed by PCR⁃
RFLP. Results There was statistically significant differences in the genotype distribution by the chi⁃square test in the
two groups (c2 = 13.710, P＝0.001). The distribution of allele frequencies in AgP group was statistically different (c2
＝
13.213, P < 0.001) from the healthy control group, and the OR for the G allele is 2.988 (95%CI: 1.634⁃5.465) when com⁃
pared with the C allele. Conclusion IL⁃6 ⁃572 gene polymorphism is associated with the susceptibility to AgP in Chi⁃
nese Han population of Guangdong, and the IL⁃6 ⁃572 G allele might be a risk factor of the genetic susceptibility to AgP. |
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| ISSN: | 2096-1456 2096-1456 |