Low Cholesterol Levels in Younger Heart Failure Patients May Predict Unfavorable Outcomes
<i>Background and Objectives:</i> Hypercholesterolemia is a main risk-factor leading to ischemic heart disease (IHD). However, among patients with heart failure, the use of lipid lowering drugs in the presence of low cholesterol might be dangerous. This 18-year longitudinal study of pati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/7/1314 |
| _version_ | 1797588356107862016 |
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| author | Lior Charach Itamar Grosskopf Leonid Galin Irit Guterman Eli Karniel Gideon Charach |
| author_facet | Lior Charach Itamar Grosskopf Leonid Galin Irit Guterman Eli Karniel Gideon Charach |
| author_sort | Lior Charach |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Hypercholesterolemia is a main risk-factor leading to ischemic heart disease (IHD). However, among patients with heart failure, the use of lipid lowering drugs in the presence of low cholesterol might be dangerous. This 18-year longitudinal study of patients ≤51 years old investigated the relationship between baseline total cholesterol, low-density lipoprotein cholesterol (LDL-c) and triglyceride levels, and survival among patients with severe HF. <i>Materials and Methods:</i> The average NYHA score of 82 patients ≤51 years old with heart failure was 2.61. They were followed for a mean of 11.3 years (15 months–20 years). Total mortality was 22%. Patients were divided into three groups. Group 1 had plasma LDL-c levels ≤ 80 mg/dl, Group 2, 80–115 mg/dl and Group 3 > 115 mg/dl. <i>Results:</i> Patients with the highest baseline total cholesterol, triglyceride and LDL-c levels > 115 mg/dl had a better survival rate (83%) compared to those with LDL-c < 80 mg/dl (50% survival, <i>p</i> = 0.043). The association between higher LDL-c levels and lower mortality was most noticeable among patients with heart failure. <i>Conclusion:</i> Longitudinal follow-up found that low LDL-c levels may indicate poorer prognosis among patient with heart failure who are ≤51 years old, similar to elderly heart failure patients. Cholesterol lowering drugs in younger patients with heart failure may increase mortality. |
| first_indexed | 2024-03-11T00:50:49Z |
| format | Article |
| id | doaj.art-6007bcb82ddd42cda132dfa08a08167b |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T00:50:49Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-6007bcb82ddd42cda132dfa08a08167b2023-11-18T20:25:02ZengMDPI AGMedicina1010-660X1648-91442023-07-01597131410.3390/medicina59071314Low Cholesterol Levels in Younger Heart Failure Patients May Predict Unfavorable OutcomesLior Charach0Itamar Grosskopf1Leonid Galin2Irit Guterman3Eli Karniel4Gideon Charach5Department of Internal Medicine B, Meir Medical Center, Kfar Saba 4428164, IsraelDepartment of Internal Medicine B, Meir Medical Center, Kfar Saba 4428164, IsraelDepartment of Internal Medicine B, Meir Medical Center, Kfar Saba 4428164, IsraelDepartment of Internal Medicine B, Meir Medical Center, Kfar Saba 4428164, IsraelDepartment of Internal Medicine B, Meir Medical Center, Kfar Saba 4428164, IsraelDepartment of Internal Medicine B, Meir Medical Center, Kfar Saba 4428164, Israel<i>Background and Objectives:</i> Hypercholesterolemia is a main risk-factor leading to ischemic heart disease (IHD). However, among patients with heart failure, the use of lipid lowering drugs in the presence of low cholesterol might be dangerous. This 18-year longitudinal study of patients ≤51 years old investigated the relationship between baseline total cholesterol, low-density lipoprotein cholesterol (LDL-c) and triglyceride levels, and survival among patients with severe HF. <i>Materials and Methods:</i> The average NYHA score of 82 patients ≤51 years old with heart failure was 2.61. They were followed for a mean of 11.3 years (15 months–20 years). Total mortality was 22%. Patients were divided into three groups. Group 1 had plasma LDL-c levels ≤ 80 mg/dl, Group 2, 80–115 mg/dl and Group 3 > 115 mg/dl. <i>Results:</i> Patients with the highest baseline total cholesterol, triglyceride and LDL-c levels > 115 mg/dl had a better survival rate (83%) compared to those with LDL-c < 80 mg/dl (50% survival, <i>p</i> = 0.043). The association between higher LDL-c levels and lower mortality was most noticeable among patients with heart failure. <i>Conclusion:</i> Longitudinal follow-up found that low LDL-c levels may indicate poorer prognosis among patient with heart failure who are ≤51 years old, similar to elderly heart failure patients. Cholesterol lowering drugs in younger patients with heart failure may increase mortality.https://www.mdpi.com/1648-9144/59/7/1314cholesterolheart failurelow density lipoproteinstatins |
| spellingShingle | Lior Charach Itamar Grosskopf Leonid Galin Irit Guterman Eli Karniel Gideon Charach Low Cholesterol Levels in Younger Heart Failure Patients May Predict Unfavorable Outcomes Medicina cholesterol heart failure low density lipoprotein statins |
| title | Low Cholesterol Levels in Younger Heart Failure Patients May Predict Unfavorable Outcomes |
| title_full | Low Cholesterol Levels in Younger Heart Failure Patients May Predict Unfavorable Outcomes |
| title_fullStr | Low Cholesterol Levels in Younger Heart Failure Patients May Predict Unfavorable Outcomes |
| title_full_unstemmed | Low Cholesterol Levels in Younger Heart Failure Patients May Predict Unfavorable Outcomes |
| title_short | Low Cholesterol Levels in Younger Heart Failure Patients May Predict Unfavorable Outcomes |
| title_sort | low cholesterol levels in younger heart failure patients may predict unfavorable outcomes |
| topic | cholesterol heart failure low density lipoprotein statins |
| url | https://www.mdpi.com/1648-9144/59/7/1314 |
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