Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia <i>Oreochromis niloticus</i> (L.)
Florfenicol (FFC), an approved aquaculture antibiotic, is administered in feed at doses of 10–15 mg kg biomass<sup>−1</sup> day<sup>−1</sup> for 10 successive days. In this study, healthy <i>Oreochromis niloticus</i> were fed with 0–10 times the therapeutic dose o...
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MDPI AG
2023-01-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/1/36 |
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| author | Avishek Bardhan Thangapalam Jawahar Abraham Jasmine Singha Ravindran Rajisha Edaparambil Krishnappan Nanitha Krishna Satyen Kumar Panda Prasanna Kumar Patil |
| author_facet | Avishek Bardhan Thangapalam Jawahar Abraham Jasmine Singha Ravindran Rajisha Edaparambil Krishnappan Nanitha Krishna Satyen Kumar Panda Prasanna Kumar Patil |
| author_sort | Avishek Bardhan |
| collection | DOAJ |
| description | Florfenicol (FFC), an approved aquaculture antibiotic, is administered in feed at doses of 10–15 mg kg biomass<sup>−1</sup> day<sup>−1</sup> for 10 successive days. In this study, healthy <i>Oreochromis niloticus</i> were fed with 0–10 times the therapeutic dose of 15 mg kg biomass<sup>−1</sup> day<sup>−1</sup> for 10 days and tracked for 43 days post dosing. Assessments of residue accrual and depletion, oxidative stress, serum biochemistry, histopathology and extent of kidney and liver damages were made. FFC dosing reduced the feed intake significantly. The therapeutic dose produced no mortalities on day 10. Dose-dependent alterations in serum biochemistry were noted upon dosing. Several histopathological alterations were observed in the kidney and liver, which vindicated the toxic potentials of FFC. The residual FFC and florfenicol amine (FFA) accrual, depletion and oxidative stress responses, such as increased malondialdehyde, total nitric oxide, ferric reducing antioxidant power and reduced glutathione S-transferase activity, were documented. The dietary FFC persuaded the physiological state of <i>O. niloticus</i>, the effects of which normalized sparsely with time upon cessation of dosing at the higher doses. The study provided a brief outlook on the physiological responses upon oral FFC administration, which should be kept in mind during its application for fish health safety purposes. |
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| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T11:03:16Z |
| publishDate | 2023-01-01 |
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| series | Veterinary Sciences |
| spelling | doaj.art-6008c499f1504cabb4815c1f82f025412023-12-01T01:07:57ZengMDPI AGVeterinary Sciences2306-73812023-01-011013610.3390/vetsci10010036Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia <i>Oreochromis niloticus</i> (L.)Avishek Bardhan0Thangapalam Jawahar Abraham1Jasmine Singha2Ravindran Rajisha3Edaparambil Krishnappan Nanitha Krishna4Satyen Kumar Panda5Prasanna Kumar Patil6Department of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata 700094, IndiaDepartment of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata 700094, IndiaDepartment of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata 700094, IndiaFish Processing Division, ICAR—Central Institute of Fisheries Technology, Willington Island, Cochin 682029, IndiaFish Processing Division, ICAR—Central Institute of Fisheries Technology, Willington Island, Cochin 682029, IndiaFish Processing Division, ICAR—Central Institute of Fisheries Technology, Willington Island, Cochin 682029, IndiaAquatic Animal Health and Environment Division, ICAR—Central Institute of Brackishwater Aquaculture, Chennai 600028, IndiaFlorfenicol (FFC), an approved aquaculture antibiotic, is administered in feed at doses of 10–15 mg kg biomass<sup>−1</sup> day<sup>−1</sup> for 10 successive days. In this study, healthy <i>Oreochromis niloticus</i> were fed with 0–10 times the therapeutic dose of 15 mg kg biomass<sup>−1</sup> day<sup>−1</sup> for 10 days and tracked for 43 days post dosing. Assessments of residue accrual and depletion, oxidative stress, serum biochemistry, histopathology and extent of kidney and liver damages were made. FFC dosing reduced the feed intake significantly. The therapeutic dose produced no mortalities on day 10. Dose-dependent alterations in serum biochemistry were noted upon dosing. Several histopathological alterations were observed in the kidney and liver, which vindicated the toxic potentials of FFC. The residual FFC and florfenicol amine (FFA) accrual, depletion and oxidative stress responses, such as increased malondialdehyde, total nitric oxide, ferric reducing antioxidant power and reduced glutathione S-transferase activity, were documented. The dietary FFC persuaded the physiological state of <i>O. niloticus</i>, the effects of which normalized sparsely with time upon cessation of dosing at the higher doses. The study provided a brief outlook on the physiological responses upon oral FFC administration, which should be kept in mind during its application for fish health safety purposes.https://www.mdpi.com/2306-7381/10/1/36florfenicol-feedingserum biochemistryantibiotic residueshepatotoxicityrenal toxicityhistological aberrations |
| spellingShingle | Avishek Bardhan Thangapalam Jawahar Abraham Jasmine Singha Ravindran Rajisha Edaparambil Krishnappan Nanitha Krishna Satyen Kumar Panda Prasanna Kumar Patil Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia <i>Oreochromis niloticus</i> (L.) Veterinary Sciences florfenicol-feeding serum biochemistry antibiotic residues hepatotoxicity renal toxicity histological aberrations |
| title | Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia <i>Oreochromis niloticus</i> (L.) |
| title_full | Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia <i>Oreochromis niloticus</i> (L.) |
| title_fullStr | Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia <i>Oreochromis niloticus</i> (L.) |
| title_full_unstemmed | Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia <i>Oreochromis niloticus</i> (L.) |
| title_short | Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia <i>Oreochromis niloticus</i> (L.) |
| title_sort | impacts of oral florfenicol medication and residues on the kidney and liver of nile tilapia i oreochromis niloticus i l |
| topic | florfenicol-feeding serum biochemistry antibiotic residues hepatotoxicity renal toxicity histological aberrations |
| url | https://www.mdpi.com/2306-7381/10/1/36 |
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