The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus
Introduction: Oral lichen planus (OLP) is a condition frequently referred to the specialist dental clinic for diagnosis and management. It is a disease of the skin and mucous membranes with oral manifestations too. It varies in appearance from keratotic to erythematous and ulcerative form. Immun...
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| Language: | English |
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JCDR Research and Publications Private Limited
2016-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/7101/15934_CE[Ra1]_F(AK)_PF1(VSUAK)_PFA(AK)_PF2(PAG).pdf |
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| author | Rahul Raviraj Shetty Krishna Nagappa Burde Kruthika Satyabodh Guttal |
| author_facet | Rahul Raviraj Shetty Krishna Nagappa Burde Kruthika Satyabodh Guttal |
| author_sort | Rahul Raviraj Shetty |
| collection | DOAJ |
| description | Introduction: Oral lichen planus (OLP) is a condition frequently
referred to the specialist dental clinic for diagnosis and
management. It is a disease of the skin and mucous membranes
with oral manifestations too. It varies in appearance from keratotic
to erythematous and ulcerative form. Immunosuppressants are
frequently used for patients but some of these drugs could be
implicated in malignant transformation, thus there is a clear
need to find an alternative therapy for OLP.
Aim: To evaluate the relief of symptoms and reduction in the size
of the lesions of lichen planus with 0.2% hyaluronic acid topical
application and to compare the efficacy of topical hyaluronic
acid (0.2%) with that of patients on placebo.
Materials and Methods: A randomized controlled study was
conducted on 50 symptomatic and biopsy proven patients with
lichen planus. The subjective symptoms like Visual Analogue
Scale (VAS) and the objective symptoms like degree of erythema
and mean area of the lesion were recorded preoperatively and
on day 7, day 14, day 21 and day 28. The selected patients
were divided randomly into group-I comprising of 25 patients
who received topical 0.2% hyaluronic acid therapy for 14 days
and group-II comprising of 25 patients who received topical
application of placebo for 14 days. The statistical tests used
were Mann-Whitney U test, t-test, Wilcoxon matched pairs test
by ranks and paired t-test.
Results: Symptomatic effect of soreness evaluation- there
was a significant reduction in VAS scores in the test group
as compared to placebo, similarly there was also significant
reduction in the degree of erythema, change in the size of
the lesion and area of the lesion in the test group. There was
significant improvement in relief of symptoms, in the degree
of erythema and mean area of the lesion in Group-I when
compared with group-II.
Conclusion: Topical application of 0.2% Hyaluronic acid
showed a significant clinical response when compared to topical
placebo. It is easy to use; hence a frequent application scheme
should be advised to improve the efficacy of hyaluronic acid. |
| first_indexed | 2024-12-21T05:30:40Z |
| format | Article |
| id | doaj.art-600a2ba86c6e40caae3995e8d4d867ee |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T05:30:40Z |
| publishDate | 2016-01-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-600a2ba86c6e40caae3995e8d4d867ee2022-12-21T19:14:32ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-01-01101ZC46ZC5010.7860/JCDR/2016/15934.7101The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen PlanusRahul Raviraj Shetty0Krishna Nagappa Burde1Kruthika Satyabodh Guttal2Assistant Professor, Department of Oral Medicine & Radiology, Bharati Vidyapeeth Dental College & Hospital, Navi –Mumbai, India.Professor and Head of Department, Department of Oral Medicine and Maxillofacial Radiology, SDM Dental College and Hospital, Dharwad, Karnataka, India.Associate Professor, Department of Oral Medicine and Maxillofacial Radiology, SDM Dental College and Hospital, Dharwad, India.Introduction: Oral lichen planus (OLP) is a condition frequently referred to the specialist dental clinic for diagnosis and management. It is a disease of the skin and mucous membranes with oral manifestations too. It varies in appearance from keratotic to erythematous and ulcerative form. Immunosuppressants are frequently used for patients but some of these drugs could be implicated in malignant transformation, thus there is a clear need to find an alternative therapy for OLP. Aim: To evaluate the relief of symptoms and reduction in the size of the lesions of lichen planus with 0.2% hyaluronic acid topical application and to compare the efficacy of topical hyaluronic acid (0.2%) with that of patients on placebo. Materials and Methods: A randomized controlled study was conducted on 50 symptomatic and biopsy proven patients with lichen planus. The subjective symptoms like Visual Analogue Scale (VAS) and the objective symptoms like degree of erythema and mean area of the lesion were recorded preoperatively and on day 7, day 14, day 21 and day 28. The selected patients were divided randomly into group-I comprising of 25 patients who received topical 0.2% hyaluronic acid therapy for 14 days and group-II comprising of 25 patients who received topical application of placebo for 14 days. The statistical tests used were Mann-Whitney U test, t-test, Wilcoxon matched pairs test by ranks and paired t-test. Results: Symptomatic effect of soreness evaluation- there was a significant reduction in VAS scores in the test group as compared to placebo, similarly there was also significant reduction in the degree of erythema, change in the size of the lesion and area of the lesion in the test group. There was significant improvement in relief of symptoms, in the degree of erythema and mean area of the lesion in Group-I when compared with group-II. Conclusion: Topical application of 0.2% Hyaluronic acid showed a significant clinical response when compared to topical placebo. It is easy to use; hence a frequent application scheme should be advised to improve the efficacy of hyaluronic acid.https://jcdr.net/articles/PDF/7101/15934_CE[Ra1]_F(AK)_PF1(VSUAK)_PFA(AK)_PF2(PAG).pdfcircuminoidscorticosteroidsinflammatory mucocutaneous disorderplaceboulcerative lesions |
| spellingShingle | Rahul Raviraj Shetty Krishna Nagappa Burde Kruthika Satyabodh Guttal The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus Journal of Clinical and Diagnostic Research circuminoids corticosteroids inflammatory mucocutaneous disorder placebo ulcerative lesions |
| title | The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus |
| title_full | The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus |
| title_fullStr | The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus |
| title_full_unstemmed | The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus |
| title_short | The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus |
| title_sort | efficacy of topical hyaluronic acid 0 2 in the management of symptomatic oral lichen planus |
| topic | circuminoids corticosteroids inflammatory mucocutaneous disorder placebo ulcerative lesions |
| url | https://jcdr.net/articles/PDF/7101/15934_CE[Ra1]_F(AK)_PF1(VSUAK)_PFA(AK)_PF2(PAG).pdf |
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