Fluorine effect in nucleophilic fluorination at C4 of 1,6-anhydro-2,3-dideoxy-2,3-difluoro-β-D-hexopyranose
In this work, we have developed a simple synthetic approach using Et3N·3HF as an alternative to the DAST reagent. We controlled the stereochemistry of the nucleophilic fluorination at C4 of 1,6-anhydro-2,3-dideoxy-2,3-difluoro-4-O-triflate-β-ᴅ-talopyranose using Et3N·3HF or in situ generated Et3N·1H...
Main Authors: | Danny Lainé, Vincent Denavit, Olivier Lessard, Laurie Carrier, Charles-Émile Fecteau, Paul A. Johnson, Denis Giguère |
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Format: | Article |
Language: | English |
Published: |
Beilstein-Institut
2020-11-01
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Series: | Beilstein Journal of Organic Chemistry |
Subjects: | |
Online Access: | https://doi.org/10.3762/bjoc.16.237 |
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