MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway
Gastric cancer is a common tumor with high morbidity and mortality. MicroRNA (miRNA) can regulate gene expression at the translation level and various tumorigenesis processes, playing an important role in tumor occurrence and prognosis. This study aims to screen miRNA associated with gastric cancer...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Current Issues in Molecular Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1467-3045/44/9/263 |
| _version_ | 1797489867108646912 |
|---|---|
| author | Wenjia Liu Nanjiao Ying Xin Rao Xiaodong Chen |
| author_facet | Wenjia Liu Nanjiao Ying Xin Rao Xiaodong Chen |
| author_sort | Wenjia Liu |
| collection | DOAJ |
| description | Gastric cancer is a common tumor with high morbidity and mortality. MicroRNA (miRNA) can regulate gene expression at the translation level and various tumorigenesis processes, playing an important role in tumor occurrence and prognosis. This study aims to screen miRNA associated with gastric cancer prognosis as biomarkers and explore the regulatory genes and related signaling pathways. In this work, R language was used for the standardization and differential analysis of miRNA and mRNA expression profiles. Samples were randomly divided into a testing group and a training group. Subsequently, we built the five miRNAs (has-miR-9-3p, has-miR-135b-3p, has-miR-143-5p, has-miR-942-3p, has-miR-196-3p) prognostic modules, verified and evaluated their prediction ability by the Cox regression analysis. They can be used as an independent factor in the prognosis of gastric cancer. By predicting and analyzing potential biological functions of the miRNA target genes, this study found that the AR gene was not only a hub gene in the PPI network, but also associated with excessive survival of patients. In conclusion, this study demonstrated that hsa-miR-942-3p could be a potential prognostic marker of gastric cancer associated with the AR and MAPK/ERK signaling pathways. The results of this study provide insights into the occurrence and development of gastric cancer. |
| first_indexed | 2024-03-10T00:22:45Z |
| format | Article |
| id | doaj.art-600a5fee08b74e8fb3c0382e5eb5d067 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-10T00:22:45Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-600a5fee08b74e8fb3c0382e5eb5d0672023-11-23T15:38:55ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-08-014493835384810.3390/cimb44090263MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling PathwayWenjia Liu0Nanjiao Ying1Xin Rao2Xiaodong Chen3School of Electronics and Information Engineering, Hangzhou Dianzi University, Hangzhou 310018, ChinaSchool of Automation, Hangzhou Dianzi University, Hangzhou 310018, ChinaSchool of Electronics and Information Engineering, Hangzhou Dianzi University, Hangzhou 310018, ChinaSchool of Electronics and Information Engineering, Hangzhou Dianzi University, Hangzhou 310018, ChinaGastric cancer is a common tumor with high morbidity and mortality. MicroRNA (miRNA) can regulate gene expression at the translation level and various tumorigenesis processes, playing an important role in tumor occurrence and prognosis. This study aims to screen miRNA associated with gastric cancer prognosis as biomarkers and explore the regulatory genes and related signaling pathways. In this work, R language was used for the standardization and differential analysis of miRNA and mRNA expression profiles. Samples were randomly divided into a testing group and a training group. Subsequently, we built the five miRNAs (has-miR-9-3p, has-miR-135b-3p, has-miR-143-5p, has-miR-942-3p, has-miR-196-3p) prognostic modules, verified and evaluated their prediction ability by the Cox regression analysis. They can be used as an independent factor in the prognosis of gastric cancer. By predicting and analyzing potential biological functions of the miRNA target genes, this study found that the AR gene was not only a hub gene in the PPI network, but also associated with excessive survival of patients. In conclusion, this study demonstrated that hsa-miR-942-3p could be a potential prognostic marker of gastric cancer associated with the AR and MAPK/ERK signaling pathways. The results of this study provide insights into the occurrence and development of gastric cancer.https://www.mdpi.com/1467-3045/44/9/263gastric cancerprognosisbiomarkerhsa-miR-942-3pARMAPK/ERK signaling pathway |
| spellingShingle | Wenjia Liu Nanjiao Ying Xin Rao Xiaodong Chen MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway Current Issues in Molecular Biology gastric cancer prognosis biomarker hsa-miR-942-3p AR MAPK/ERK signaling pathway |
| title | MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway |
| title_full | MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway |
| title_fullStr | MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway |
| title_full_unstemmed | MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway |
| title_short | MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway |
| title_sort | mir 942 3p as a potential prognostic marker of gastric cancer associated with ar and mapk erk signaling pathway |
| topic | gastric cancer prognosis biomarker hsa-miR-942-3p AR MAPK/ERK signaling pathway |
| url | https://www.mdpi.com/1467-3045/44/9/263 |
| work_keys_str_mv | AT wenjialiu mir9423pasapotentialprognosticmarkerofgastriccancerassociatedwitharandmapkerksignalingpathway AT nanjiaoying mir9423pasapotentialprognosticmarkerofgastriccancerassociatedwitharandmapkerksignalingpathway AT xinrao mir9423pasapotentialprognosticmarkerofgastriccancerassociatedwitharandmapkerksignalingpathway AT xiaodongchen mir9423pasapotentialprognosticmarkerofgastriccancerassociatedwitharandmapkerksignalingpathway |