Genomic Perspective on Mouse Liver Cancer Models
Selecting the most appropriate mouse model that best recapitulates human hepatocellular carcinoma (HCC) allows translation of preclinical mouse studies into clinical studies. In the era of cancer genomics, comprehensive and integrative analysis of the human HCC genome has allowed categorization of H...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/11/1648 |
| _version_ | 1797764653281968128 |
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| author | Sun Young Yim Ju-Seog Lee |
| author_facet | Sun Young Yim Ju-Seog Lee |
| author_sort | Sun Young Yim |
| collection | DOAJ |
| description | Selecting the most appropriate mouse model that best recapitulates human hepatocellular carcinoma (HCC) allows translation of preclinical mouse studies into clinical studies. In the era of cancer genomics, comprehensive and integrative analysis of the human HCC genome has allowed categorization of HCC according to molecular subtypes. Despite the variety of mouse models that are available for preclinical research, there is a lack of evidence for mouse models that closely resemble human HCC. Therefore, it is necessary to identify the accurate mouse models that represent human HCC based on molecular subtype as well as histologic aggressiveness. In this review, we summarize the mouse models integrated with human HCC genomic data to provide information regarding the models that recapitulates the distinct aspect of HCC biology and prognosis based on molecular subtypes. |
| first_indexed | 2024-03-12T19:58:51Z |
| format | Article |
| id | doaj.art-600b7422a00a4b65a48f7449ce29379a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:58:51Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-600b7422a00a4b65a48f7449ce29379a2023-08-02T02:36:04ZengMDPI AGCancers2072-66942019-10-011111164810.3390/cancers11111648cancers11111648Genomic Perspective on Mouse Liver Cancer ModelsSun Young Yim0Ju-Seog Lee1Department of Internal Medicine, Division of Gastroenterology and Hepatology, Korea University College of Medicine, Seoul 136-701, KoreaDepartment of Systems Biology, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASelecting the most appropriate mouse model that best recapitulates human hepatocellular carcinoma (HCC) allows translation of preclinical mouse studies into clinical studies. In the era of cancer genomics, comprehensive and integrative analysis of the human HCC genome has allowed categorization of HCC according to molecular subtypes. Despite the variety of mouse models that are available for preclinical research, there is a lack of evidence for mouse models that closely resemble human HCC. Therefore, it is necessary to identify the accurate mouse models that represent human HCC based on molecular subtype as well as histologic aggressiveness. In this review, we summarize the mouse models integrated with human HCC genomic data to provide information regarding the models that recapitulates the distinct aspect of HCC biology and prognosis based on molecular subtypes.https://www.mdpi.com/2072-6694/11/11/1648mouse modelhepatocellular carcinomactnnb1arid1asv40genomicshippo pathwaygenomic resemblance |
| spellingShingle | Sun Young Yim Ju-Seog Lee Genomic Perspective on Mouse Liver Cancer Models Cancers mouse model hepatocellular carcinoma ctnnb1 arid1a sv40 genomics hippo pathway genomic resemblance |
| title | Genomic Perspective on Mouse Liver Cancer Models |
| title_full | Genomic Perspective on Mouse Liver Cancer Models |
| title_fullStr | Genomic Perspective on Mouse Liver Cancer Models |
| title_full_unstemmed | Genomic Perspective on Mouse Liver Cancer Models |
| title_short | Genomic Perspective on Mouse Liver Cancer Models |
| title_sort | genomic perspective on mouse liver cancer models |
| topic | mouse model hepatocellular carcinoma ctnnb1 arid1a sv40 genomics hippo pathway genomic resemblance |
| url | https://www.mdpi.com/2072-6694/11/11/1648 |
| work_keys_str_mv | AT sunyoungyim genomicperspectiveonmouselivercancermodels AT juseoglee genomicperspectiveonmouselivercancermodels |