Deletion of the ORF2 gene of the neuropathogenic equine herpesvirus type 1 strain Ab4 reduces virulence while maintaining strong immunogenicity

Deletion of the ORF2 gene of the neuropathogenic equine herpesvirus type 1 strain Ab4 reduces virulence while maintaining strong immunogenicity

Abstract Background Equine herpesvirus type 1 (EHV-1) induces respiratory infection, abortion, and neurologic disease with significant impact. Virulence factors contributing to infection and immune evasion are of particular interest. A potential virulence factor of the neuropathogenic EHV-1 strain A...

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Bibliographic Details
Main Authors: Christiane L. Schnabel, Christine L. Wimer, Gillian Perkins, Susanna Babasyan, Heather Freer, Christina Watts, Alicia Rollins, Nikolaus Osterrieder, Bettina Wagner
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Veterinary Research
Subjects:
Horse
EHV-1
ORF2
Virulence factor
Immunoglobulin
Mucosal immune response
Online Access:http://link.springer.com/article/10.1186/s12917-018-1563-4

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