A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice

A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice

Gamma-aminobutyric acid (GABA) and GABA-receptors (GABA-Rs) form a major neurotransmitter system in the brain. GABA-Rs are also expressed by 1) cells of the innate and adaptive immune system and act to inhibit their inflammatory activities, and 2) lung epithelial cells and GABA-R agonists/potentiato...

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Bibliographic Details
Main Authors: Jide Tian, Barbara J. Dillion, Jill Henley, Lucio Comai, Daniel L. Kaufman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
gaba
GABA-receptors
COVID-19
SARS-CoV-2
antiviral
long-covid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007955/full

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