Association between diabetes mellitus and immunity to some bacterial infections
Background: Diabetes mellitus (DM) is a major public health problem, affecting about 10% of the population, its pathogenesis and possible causes are still unclear. Helicobacter pylori (H. pylori) and Salmonella spp. are one of the most common human bacterial pathogens, and infection causes a wide ar...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of the Scientific Society |
| Subjects: | |
| Online Access: | http://www.jscisociety.com/article.asp?issn=0974-5009;year=2023;volume=50;issue=2;spage=193;epage=196;aulast=Ali |
| _version_ | 1797738455908745216 |
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| author | Mustafa Hussam Abd Ali Al-Jamal Falah Hasan Obayes Al-Khikani |
| author_facet | Mustafa Hussam Abd Ali Al-Jamal Falah Hasan Obayes Al-Khikani |
| author_sort | Mustafa Hussam Abd Ali Al-Jamal |
| collection | DOAJ |
| description | Background: Diabetes mellitus (DM) is a major public health problem, affecting about 10% of the population, its pathogenesis and possible causes are still unclear. Helicobacter pylori (H. pylori) and Salmonella spp. are one of the most common human bacterial pathogens, and infection causes a wide array of systemic and gastric disorders. The aim of this study is to find a possible correlation between DM and immunity to some bacterial infections. Materials and Methods: A total of 100 serum specimens were collected from different groups, 34 patients with diabetes mellitus, 33 patients with prediabetic, and 33 persons as a control group. All these samples tested for random blood sugars (RBSs), immunoglobulin G (IgG) antibody to H. pylori, antibodies to Salmonella typhi and Salmonella paratyphi, serum urea, and serum creatinine. Results: The mean of RBS in diabetic patients was 297.44 ± 84.662, while for the control group, it was 93.44 ± 9.702, with a high significant difference (P = 0.000). The prevalence of S. typhi and S. paratyphi among diabetic, prediabetic, and control groups was 32.35%, 27.27%, and 48.48%, respectively. No significant differences in urea and creatinine between all groups at P = 0.67 and P = 0.23, respectively. Conclusions: Significant differences between diabetic and control groups regarding IgG antibodies to H. pylori have been observed (P = 0.04). Hence, these antibodies represent a risk factor in DM. In spite of the high percentage of positive results for S. typhi and S. paratyphi in the control groups 48.48% compared to the diabetic group 32.35%, it is still insignificant at P = 0.17. Hence, antibodies to Salmonella spp. may represent the protective factor. |
| first_indexed | 2024-03-12T13:44:03Z |
| format | Article |
| id | doaj.art-600cb095b68b47cfa8bd50223a8680d4 |
| institution | Directory Open Access Journal |
| issn | 0974-5009 |
| language | English |
| last_indexed | 2024-03-12T13:44:03Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Scientific Society |
| spelling | doaj.art-600cb095b68b47cfa8bd50223a8680d42023-08-23T09:45:28ZengWolters Kluwer Medknow PublicationsJournal of the Scientific Society0974-50092023-01-0150219319610.4103/jss.jss_143_22Association between diabetes mellitus and immunity to some bacterial infectionsMustafa Hussam Abd Ali Al-JamalFalah Hasan Obayes Al-KhikaniBackground: Diabetes mellitus (DM) is a major public health problem, affecting about 10% of the population, its pathogenesis and possible causes are still unclear. Helicobacter pylori (H. pylori) and Salmonella spp. are one of the most common human bacterial pathogens, and infection causes a wide array of systemic and gastric disorders. The aim of this study is to find a possible correlation between DM and immunity to some bacterial infections. Materials and Methods: A total of 100 serum specimens were collected from different groups, 34 patients with diabetes mellitus, 33 patients with prediabetic, and 33 persons as a control group. All these samples tested for random blood sugars (RBSs), immunoglobulin G (IgG) antibody to H. pylori, antibodies to Salmonella typhi and Salmonella paratyphi, serum urea, and serum creatinine. Results: The mean of RBS in diabetic patients was 297.44 ± 84.662, while for the control group, it was 93.44 ± 9.702, with a high significant difference (P = 0.000). The prevalence of S. typhi and S. paratyphi among diabetic, prediabetic, and control groups was 32.35%, 27.27%, and 48.48%, respectively. No significant differences in urea and creatinine between all groups at P = 0.67 and P = 0.23, respectively. Conclusions: Significant differences between diabetic and control groups regarding IgG antibodies to H. pylori have been observed (P = 0.04). Hence, these antibodies represent a risk factor in DM. In spite of the high percentage of positive results for S. typhi and S. paratyphi in the control groups 48.48% compared to the diabetic group 32.35%, it is still insignificant at P = 0.17. Hence, antibodies to Salmonella spp. may represent the protective factor.http://www.jscisociety.com/article.asp?issn=0974-5009;year=2023;volume=50;issue=2;spage=193;epage=196;aulast=Alidiabetes mellitushelicobacter pylorihyperglycemiasalmonella paratyphisalmonella typhiseroprevalence |
| spellingShingle | Mustafa Hussam Abd Ali Al-Jamal Falah Hasan Obayes Al-Khikani Association between diabetes mellitus and immunity to some bacterial infections Journal of the Scientific Society diabetes mellitus helicobacter pylori hyperglycemia salmonella paratyphi salmonella typhi seroprevalence |
| title | Association between diabetes mellitus and immunity to some bacterial infections |
| title_full | Association between diabetes mellitus and immunity to some bacterial infections |
| title_fullStr | Association between diabetes mellitus and immunity to some bacterial infections |
| title_full_unstemmed | Association between diabetes mellitus and immunity to some bacterial infections |
| title_short | Association between diabetes mellitus and immunity to some bacterial infections |
| title_sort | association between diabetes mellitus and immunity to some bacterial infections |
| topic | diabetes mellitus helicobacter pylori hyperglycemia salmonella paratyphi salmonella typhi seroprevalence |
| url | http://www.jscisociety.com/article.asp?issn=0974-5009;year=2023;volume=50;issue=2;spage=193;epage=196;aulast=Ali |
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