RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters.

RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters.

In mammalian cells, widespread acceleration of cytoplasmic mRNA degradation is linked to impaired RNA polymerase II (Pol II) transcription. This mRNA decay-induced transcriptional repression occurs during infection with gammaherpesviruses including Kaposi's sarcoma-associated herpesvirus (KSHV)...

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Bibliographic Details
Main Authors: Ella Hartenian, Sarah Gilbertson, Joel D Federspiel, Ileana M Cristea, Britt A Glaunsinger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008269

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