Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases
Chronic diseases such as cardiovascular disease (CVD), atherosclerosis, chronic liver disease, and neurodegenerative diseases are major causes of mortality. These diseases have gained much attention due to their complications, and therefore novel approaches with fewer side effects are an important r...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/7/1273 |
| _version_ | 1797433877561606144 |
|---|---|
| author | Zahra Najafi Arab Danial Khayatan Seyed Mehrad Razavi Kimia Zare Elnaz Kheradkhah Saeideh Momtaz Gianna Ferretti Tiziana Bacchetti Thozhukat Sathyapalan Seyed Ahmad Emami Amir Hossein Abdolghaffari Amirhossein Sahebkar |
| author_facet | Zahra Najafi Arab Danial Khayatan Seyed Mehrad Razavi Kimia Zare Elnaz Kheradkhah Saeideh Momtaz Gianna Ferretti Tiziana Bacchetti Thozhukat Sathyapalan Seyed Ahmad Emami Amir Hossein Abdolghaffari Amirhossein Sahebkar |
| author_sort | Zahra Najafi Arab |
| collection | DOAJ |
| description | Chronic diseases such as cardiovascular disease (CVD), atherosclerosis, chronic liver disease, and neurodegenerative diseases are major causes of mortality. These diseases have gained much attention due to their complications, and therefore novel approaches with fewer side effects are an important research topic. Free radicals and oxidative stress are involved in the molecular mechanisms of several diseases. Antioxidants can scavenge free radicals and mitigate their adverse effects. One of the most important antioxidant enzymes are paraoxonases (PONs). These enzymes perform a wide range of physiological activities ranging from drug metabolism to detoxification of neuroleptics. Paraoxonase-1 (PON1) is produced in the liver and then transferred to the bloodstream. It has been demonstrated that PON1 could have beneficial effects in numerous diseases such as atherosclerosis, CVD, diabetes mellitus, and neurodegenerative diseases by modulating relevant signalling pathways involved in inflammation and oxidative stress. These pathways include peroxisome proliferator-activated receptor gamma (PPAR-γ) and protein kinase B/nuclear factor kappa-light-chain-enhancer of activated B cells (AKT/NF-κB)-dependent signalling pathways. Increasing PON1 could potentially have protective effects and reduce the incidence of various diseases by modulating these signalling pathways. Several studies have reported that dietary factors are able to modulate PON1 expression and activity. This review aimed at summarizing the state of the art on the effects of dietary phytochemicals on PON1 enzyme activity and the relevant signalling pathways in different diseases. |
| first_indexed | 2024-03-09T10:23:10Z |
| format | Article |
| id | doaj.art-600e8825e4b448c69f81aa04c2907e1e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T10:23:10Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-600e8825e4b448c69f81aa04c2907e1e2023-12-01T21:49:38ZengMDPI AGAntioxidants2076-39212022-06-01117127310.3390/antiox11071273Phytochemicals as Modulators of Paraoxonase-1 in Health and DiseasesZahra Najafi Arab0Danial Khayatan1Seyed Mehrad Razavi2Kimia Zare3Elnaz Kheradkhah4Saeideh Momtaz5Gianna Ferretti6Tiziana Bacchetti7Thozhukat Sathyapalan8Seyed Ahmad Emami9Amir Hossein Abdolghaffari10Amirhossein Sahebkar11Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranSchool of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, IranDepartment of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranMedicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, IranDepartment of Clinical Science, Polytechnic University of Marche, Ancona, ItalyDepartment of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, ItalyDepartment of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull HU3 2JZ, UKDepartment of Traditional Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, IranChronic diseases such as cardiovascular disease (CVD), atherosclerosis, chronic liver disease, and neurodegenerative diseases are major causes of mortality. These diseases have gained much attention due to their complications, and therefore novel approaches with fewer side effects are an important research topic. Free radicals and oxidative stress are involved in the molecular mechanisms of several diseases. Antioxidants can scavenge free radicals and mitigate their adverse effects. One of the most important antioxidant enzymes are paraoxonases (PONs). These enzymes perform a wide range of physiological activities ranging from drug metabolism to detoxification of neuroleptics. Paraoxonase-1 (PON1) is produced in the liver and then transferred to the bloodstream. It has been demonstrated that PON1 could have beneficial effects in numerous diseases such as atherosclerosis, CVD, diabetes mellitus, and neurodegenerative diseases by modulating relevant signalling pathways involved in inflammation and oxidative stress. These pathways include peroxisome proliferator-activated receptor gamma (PPAR-γ) and protein kinase B/nuclear factor kappa-light-chain-enhancer of activated B cells (AKT/NF-κB)-dependent signalling pathways. Increasing PON1 could potentially have protective effects and reduce the incidence of various diseases by modulating these signalling pathways. Several studies have reported that dietary factors are able to modulate PON1 expression and activity. This review aimed at summarizing the state of the art on the effects of dietary phytochemicals on PON1 enzyme activity and the relevant signalling pathways in different diseases.https://www.mdpi.com/2076-3921/11/7/1273Paraoxonase-1Paraoxonase familyphytochemicalsdiseasesinflammationoxidative stress |
| spellingShingle | Zahra Najafi Arab Danial Khayatan Seyed Mehrad Razavi Kimia Zare Elnaz Kheradkhah Saeideh Momtaz Gianna Ferretti Tiziana Bacchetti Thozhukat Sathyapalan Seyed Ahmad Emami Amir Hossein Abdolghaffari Amirhossein Sahebkar Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases Antioxidants Paraoxonase-1 Paraoxonase family phytochemicals diseases inflammation oxidative stress |
| title | Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases |
| title_full | Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases |
| title_fullStr | Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases |
| title_full_unstemmed | Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases |
| title_short | Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases |
| title_sort | phytochemicals as modulators of paraoxonase 1 in health and diseases |
| topic | Paraoxonase-1 Paraoxonase family phytochemicals diseases inflammation oxidative stress |
| url | https://www.mdpi.com/2076-3921/11/7/1273 |
| work_keys_str_mv | AT zahranajafiarab phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT danialkhayatan phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT seyedmehradrazavi phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT kimiazare phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT elnazkheradkhah phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT saeidehmomtaz phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT giannaferretti phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT tizianabacchetti phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT thozhukatsathyapalan phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT seyedahmademami phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT amirhosseinabdolghaffari phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases AT amirhosseinsahebkar phytochemicalsasmodulatorsofparaoxonase1inhealthanddiseases |