A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors
The present coronavirus disease 2019 (COVID-19) pandemic scenario has posed a difficulty for cancer treatment. Even under ideal conditions, malignancies like small cell lung cancer (SCLC) are challenging to treat because of their fast development and early metastases. The treatment of these patients...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2023-10-01
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| Series: | Exploration of Targeted Anti-tumor Therapy |
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| Online Access: | https://www.explorationpub.com/Journals/etat/Article/1002177 |
| _version_ | 1797649220517232640 |
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| author | Babak Sokouti |
| author_facet | Babak Sokouti |
| author_sort | Babak Sokouti |
| collection | DOAJ |
| description | The present coronavirus disease 2019 (COVID-19) pandemic scenario has posed a difficulty for cancer treatment. Even under ideal conditions, malignancies like small cell lung cancer (SCLC) are challenging to treat because of their fast development and early metastases. The treatment of these patients must not be jeopardized, and they must be protected as much as possible from the continuous spread of the COVID-19 infection. Initially identified in December 2019 in Wuhan, China, the contagious coronavirus illness 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Finding inhibitors against the druggable targets of SARS-CoV-2 has been a significant focus of research efforts across the globe. The primary motivation for using molecular modeling tools against SARS-CoV-2 was to identify candidates for use as therapeutic targets from a pharmacological database. In the published study, scientists used a combination of medication repurposing and virtual drug screening methodologies to target many structures of SARS-CoV-2. This virus plays an essential part in the maturation and replication of other viruses. In addition, the total binding free energy and molecular dynamics (MD) modeling findings showed that the dynamics of various medications and substances were stable; some of them have been tested experimentally against SARS-CoV-2. Different virtual screening (VS) methods have been discussed as potential means by which the evaluated medications that show strong binding to the active site might be repurposed for use against SARS-CoV-2. |
| first_indexed | 2024-03-11T15:44:05Z |
| format | Article |
| id | doaj.art-600eadca334b438d9a0edf6ef88db68a |
| institution | Directory Open Access Journal |
| issn | 2692-3114 |
| language | English |
| last_indexed | 2024-03-11T15:44:05Z |
| publishDate | 2023-10-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Targeted Anti-tumor Therapy |
| spelling | doaj.art-600eadca334b438d9a0edf6ef88db68a2023-10-26T07:35:14ZengOpen Exploration Publishing Inc.Exploration of Targeted Anti-tumor Therapy2692-31142023-10-0145994102610.37349/etat.2023.00177A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitorsBabak Sokouti0https://orcid.org/0000-0002-8160-0301Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665813, IranThe present coronavirus disease 2019 (COVID-19) pandemic scenario has posed a difficulty for cancer treatment. Even under ideal conditions, malignancies like small cell lung cancer (SCLC) are challenging to treat because of their fast development and early metastases. The treatment of these patients must not be jeopardized, and they must be protected as much as possible from the continuous spread of the COVID-19 infection. Initially identified in December 2019 in Wuhan, China, the contagious coronavirus illness 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Finding inhibitors against the druggable targets of SARS-CoV-2 has been a significant focus of research efforts across the globe. The primary motivation for using molecular modeling tools against SARS-CoV-2 was to identify candidates for use as therapeutic targets from a pharmacological database. In the published study, scientists used a combination of medication repurposing and virtual drug screening methodologies to target many structures of SARS-CoV-2. This virus plays an essential part in the maturation and replication of other viruses. In addition, the total binding free energy and molecular dynamics (MD) modeling findings showed that the dynamics of various medications and substances were stable; some of them have been tested experimentally against SARS-CoV-2. Different virtual screening (VS) methods have been discussed as potential means by which the evaluated medications that show strong binding to the active site might be repurposed for use against SARS-CoV-2.https://www.explorationpub.com/Journals/etat/Article/1002177virtual screeningcoronavirus disease 2019cancersevere acute respiratory syndrome coronavirus 2molecular dynamicsdockingrepurposing |
| spellingShingle | Babak Sokouti A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors Exploration of Targeted Anti-tumor Therapy virtual screening coronavirus disease 2019 cancer severe acute respiratory syndrome coronavirus 2 molecular dynamics docking repurposing |
| title | A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors |
| title_full | A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors |
| title_fullStr | A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors |
| title_full_unstemmed | A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors |
| title_short | A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors |
| title_sort | review on in silico virtual screening methods in covid 19 using anticancer drugs and other natural chemical inhibitors |
| topic | virtual screening coronavirus disease 2019 cancer severe acute respiratory syndrome coronavirus 2 molecular dynamics docking repurposing |
| url | https://www.explorationpub.com/Journals/etat/Article/1002177 |
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