Extracellular vesicles of bacteria as potential targets for immune interventions
Bacterial infection is one of the most common and serious diseases. Extracellular vesicles (EVs) expressed by bacterial cells during infection and their biological functions have been a growing field in recent years. The study of the immune interaction mechanism between EVs and bacteria has become m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-03-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1799667 |
| _version_ | 1797677279904530432 |
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| author | Yizhi Peng Sheng Yin Min Wang |
| author_facet | Yizhi Peng Sheng Yin Min Wang |
| author_sort | Yizhi Peng |
| collection | DOAJ |
| description | Bacterial infection is one of the most common and serious diseases. Extracellular vesicles (EVs) expressed by bacterial cells during infection and their biological functions have been a growing field in recent years. The study of the immune interaction mechanism between EVs and bacteria has become more significant. EVs are released into the extracellular microenvironment during bacterial infection. EVs carry various lipids, proteins, nucleic acids, and other substances of host bacteria and participate in various physiological and pathological processes. EV-based vaccines against bacterial infection are also being evaluated. This review focuses on the biological characteristics of EVs, the interaction between EVs and the host immune system, and the potential of EVs as new vaccines. A deeper understanding of the interaction between EVs and the immune system informs on the biological function and heterogeneity of EVs. This knowledge also can facilitate the development and application of EVs and their potential as vaccines. |
| first_indexed | 2024-03-11T22:42:34Z |
| format | Article |
| id | doaj.art-6011ef91633f4ceba79311a51aa596f5 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:42:34Z |
| publishDate | 2021-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-6011ef91633f4ceba79311a51aa596f52023-09-22T08:51:50ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-03-0117389790310.1080/21645515.2020.17996671799667Extracellular vesicles of bacteria as potential targets for immune interventionsYizhi Peng0Sheng Yin1Min Wang2The Second Xiangya Hospital of Central South UniversityThe Second Xiangya Hospital of Central South UniversityThe Second Xiangya Hospital of Central South UniversityBacterial infection is one of the most common and serious diseases. Extracellular vesicles (EVs) expressed by bacterial cells during infection and their biological functions have been a growing field in recent years. The study of the immune interaction mechanism between EVs and bacteria has become more significant. EVs are released into the extracellular microenvironment during bacterial infection. EVs carry various lipids, proteins, nucleic acids, and other substances of host bacteria and participate in various physiological and pathological processes. EV-based vaccines against bacterial infection are also being evaluated. This review focuses on the biological characteristics of EVs, the interaction between EVs and the host immune system, and the potential of EVs as new vaccines. A deeper understanding of the interaction between EVs and the immune system informs on the biological function and heterogeneity of EVs. This knowledge also can facilitate the development and application of EVs and their potential as vaccines.http://dx.doi.org/10.1080/21645515.2020.1799667evs vaccine active immunity |
| spellingShingle | Yizhi Peng Sheng Yin Min Wang Extracellular vesicles of bacteria as potential targets for immune interventions Human Vaccines & Immunotherapeutics evs vaccine active immunity |
| title | Extracellular vesicles of bacteria as potential targets for immune interventions |
| title_full | Extracellular vesicles of bacteria as potential targets for immune interventions |
| title_fullStr | Extracellular vesicles of bacteria as potential targets for immune interventions |
| title_full_unstemmed | Extracellular vesicles of bacteria as potential targets for immune interventions |
| title_short | Extracellular vesicles of bacteria as potential targets for immune interventions |
| title_sort | extracellular vesicles of bacteria as potential targets for immune interventions |
| topic | evs vaccine active immunity |
| url | http://dx.doi.org/10.1080/21645515.2020.1799667 |
| work_keys_str_mv | AT yizhipeng extracellularvesiclesofbacteriaaspotentialtargetsforimmuneinterventions AT shengyin extracellularvesiclesofbacteriaaspotentialtargetsforimmuneinterventions AT minwang extracellularvesiclesofbacteriaaspotentialtargetsforimmuneinterventions |